Role of uPAR & plasmin in bone marrow stem/progenitor cell retention and mobilization (2007)
Zowel in normale als in pathologische condities wordt de vorming van bloedcellen en -vaten bepaald door stamcellen afkomstig uit het beenmerg (BM), en door groeifactoren. Dit doctoraatsproject maakte...
Li, Xuri, Tjwa, Marc, Moons, Lieve, Fons, Pierre, Noel, Agnes, Ny, Annelii, ...
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized...
Brusselmans, Koen, Compernolle, Veerle, Tjwa, Marc, Wiesener, Michael S., Maxwell, Patrick H., Collen, Désiré, ...
Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of hypoxia-inducible factor–1α...
Brusselmans, Koen, Compernolle, Veerle, Tjwa, Marc, Wiesener, Michael S., Maxwell, Patrick H., Collen, Désiré, ...
Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of hypoxia-inducible factor–1α...
Li, Xuri, Tjwa, Marc, Moons, Lieve, Fons, Pierre, Noel, Agnes, Ny, Annelii, ...
The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized...
Umans, Lieve, Cox, Luk, Tjwa, Marc, Bito, Virginie, Vermeire, Liesbeth, Laperre, Kjell, ...
Smads are intracellular signaling proteins that transduce signals elicited by members of the transforming growth factor (TGF)-β superfamily. Smad5 and Smad1 are highly homologous, and they mediate...
Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
Tirziu, Daniela, Chorianopoulos, Emmanuel, Moodie, Karen L., Palac, Robert T., Zhuang, Zhen W., Tjwa, Marc, ...
Although studies have suggested a role for angiogenesis in determining heart size during conditions demanding enhanced cardiac performance, the role of EC mass in determining the normal organ size is...
Role of Gas6 in erythropoiesis and anemia in mice
Angelillo-Scherrer, Anne, Burnier, Laurent, Lambrechts, Diether, Fish, Richard J., Tjwa, Marc, Plaisance, Stéphane, ...
Many patients with anemia fail to respond to treatment with erythropoietin (Epo), a commonly used hormone that stimulates erythroid progenitor production and maturation by human BM or by murine...
uPA deficiency exacerbates muscular dystrophy in MDX mice
Suelves, Mònica, Vidal, Berta, Serrano, Antonio L., Tjwa, Marc, Roma, Josep, López-Alemany, Roser, ...
Duchenne muscular dystrophy (DMD) is a fatal and incurable muscle degenerative disorder. We identify a function of the protease urokinase plasminogen activator (uPA) in mdx mice, a mouse model of...
Jost, Maud, Maillard, Catherine, Lecomte, Julie, Lambert, Vincent, Tjwa, Marc, Blaise, Pierre, ...
An adequate balance between serine proteases and their plasminogen activator inhibitor-1 (PAI-1) is critical for pathological angiogenesis. PAI-1 deficiency in mice is associated with impaired...