Marks, Jennifer L., Gong, Yixuan X., Chitale, Dhananjay, Golas, Ben, McLellan, Michael D., Kasai, Yumi, ...
Somatic mutations affect key pathways in lung adenocarcinoma (2008)
Ding, Li, Getz, Gad, Wheeler, David A., Mardis, Elaine R., McLellan, Michael D., Cibulskis, Kristian, ...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib (2005)
William Pao, Theresa Y. Wang, Gregory J. Riely, Vincent A. Miller, Qiulu Pan, Marc Ladanyi, ...
Mutational analysis of the KRAS gene in lung cancer patients treated with two different kinase inhibitors suggests that tumors with KRAS mutations do not respond to these drugs.
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib (2005)
William Pao, Theresa Y. Wang, Gregory J. Riely, Vincent A. Miller, Qiulu Pan, Marc Ladanyi, ...
Background Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors...
Man, Tsz-Kwong, Lu, Xin-Yan, Jaeweon, Kim, Perlaky, Laszlo, Harris, Charles P, Shah, Shishir, ...
Abstract Background Osteosarcoma is a highly malignant bone neoplasm of children and young adults. It is characterized by extremely complex karyotypes and high frequency of chromosomal...
Overholtzer, Michael, Rao, Pulivarthi H., Favis, Reyna, Lu, Xin-Yan, Elowitz, Michael B., Barany, Francis, ...
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation...
Amplification of the MYC Gene in Osteosarcoma Secondary to Paget's Disease of Bone (1997)
Takafumi Ueda, John H. Healey, Andrew G. Huvos, Marc Ladanyi
Purpose. In a previous series of 25 human osteosarcoma samples studied for MYC gene amplification, we found amplification in two cases (8%), including one arising in association with Paget's disease...
Davis, Ian J., Hsi, Bae-Li, Arroyo, Jason D., Vargas, Sara O., Yeh, Y. Albert, Motyckova, Gabriela, ...
MITF, TFE3, TFEB, and TFEC comprise a transcription factor family (MiT) that regulates key developmental pathways in several cell lineages. Like MYC, MiT members are basic helix-loop-helix-leucine...
Overholtzer, Michael, Rao, Pulivarthi H., Favis, Reyna, Lu, Xin-Yan, Elowitz, Michael B., Barany, Francis, ...
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation...
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib
Pao, William, Wang, Theresa Y, Riely, Gregory J, Miller, Vincent A, Pan, Qiulu, Ladanyi, Marc, ...
Mutational analysis of the KRAS gene in lung cancer patients treated with two different kinase inhibitors suggests that tumors with KRAS mutations do not respond to these drugs
Khan, Javed, Wei, Jun S., Ringnér, Markus, Saal, Lao H., Ladanyi, Marc, Westermann, Frank, ...
The purpose of this study was to develop a method of classifying cancers to specific diagnostic categories based on their gene expression signatures using artificial neural networks (ANNs). We...
Davis, Ian J., Hsi, Bae-Li, Arroyo, Jason D., Vargas, Sara O., Yeh, Y. Albert, Motyckova, Gabriela, ...
MITF, TFE3, TFEB, and TFEC comprise a transcription factor family (MiT) that regulates key developmental pathways in several cell lineages. Like MYC, MiT members are basic helix-loop-helix-leucine...
Overholtzer, Michael, Rao, Pulivarthi H., Favis, Reyna, Lu, Xin-Yan, Elowitz, Michael B., Barany, Francis, ...
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation...
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib
Pao, William, Wang, Theresa Y, Riely, Gregory J, Miller, Vincent A, Pan, Qiulu, Ladanyi, Marc, ...
Mutational analysis of the KRAS gene in lung cancer patients treated with two different kinase inhibitors suggests that tumors with KRAS mutations do not respond to these drugs
Colleoni, Gisele W. B., Bridge, Julia A., Garicochea, Bernardo, Liu, Jian, Filippa, Daniel A., Ladanyi, Marc
The subset of CD30-positive anaplastic large cell lymphomas (ALCL) with the NPM-ALK gene fusion arising from the t(2;5)(p23;q35) forms a distinct clinical and prognostic entity. Recently, various...
Antonescu, Cristina R., Leung, Denis H., Dudas, Maria, Ladanyi, Marc, Brennan, Murray, Woodruff, James M., ...
Genetic alterations of cell cycle regulators are thought to represent uncommon and possible secondary events in sarcomas characterized by recurrent chromosomal translocations. The present study...
Association of EWS-FLI1 Type 1 Fusion with Lower Proliferative Rate in Ewing’s Sarcoma
De Alava, Enrique, Panizo, Angel, Antonescu, Cristina R., Huvos, Andrew G., Pardo-Mindán, F. Javier, Barr, Frederic G., ...
The Ewing’s sarcoma (ES) family of tumors, including peripheral neuroectodermal tumor (PNET), is defined genetically by specific chromosomal translocations resulting in fusion of the EWS gene with...
Argani, Pedram, Antonescu, Cristina R., Illei, Peter B., Lui, Man Yee, Timmons, Charles F., Newbury, Robert, ...
The unbalanced translocation, der(17)t(X;17)(p11.2;q25), is characteristic of alveolar soft part sarcoma (ASPS). We have recently shown that this translocation fuses the TFE3 transcription factor...
Fusion of the ALK Gene to the Clathrin Heavy Chain Gene, CLTC, in Inflammatory Myofibroblastic Tumor
Bridge, Julia A., Kanamori, Masahiko, Ma, Zhigui, Pickering, Diane, Hill, D. Ashley, Lydiatt, William, ...
Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies...
Allander, Susanne V., Illei, Peter B., Chen, Yidong, Antonescu, Cristina R., Bittner, Mike, Ladanyi, Marc, ...
Synovial sarcoma is an aggressive spindle cell sarcoma with two major histological subtypes, biphasic and monophasic, defined respectively by the presence or absence of areas of glandular epithelial...
Ladanyi, Marc, Antonescu, Cristina R., Drobnjak, Marija, Baren, Ann, Lui, Man Yee, Golde, David W., ...
Alveolar soft part sarcoma (ASPS) is an unusual tumor of young adults with the characteristic presence on ultrastructural analysis of rhomboid or rectangular cytoplasmic crystals. These...
Pan, Qiulu, Pao, William, Ladanyi, Marc
Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are present in lung adenocarcinomas that respond to the EGFR inhibitors gefitinib and erlotinib....
Antonescu, Cristina R., Elahi, Abul, Humphrey, Marcia, Lui, Man Yee, Healey, John H., Brennan, Murray F., ...
Myxoid liposarcoma (LS), the most common subtype of LS, is known to be characterized by the specific t(12;16) resulting in a TLS-CHOP fusion in almost all cases. We wished to address the following...
Expression Profiling of Human Tumors: The End of Surgical Pathology?
Ladanyi, Marc, Chan, Wing C., Triche, Timothy J., Gerald, William L.
Antonescu, Cristina R., Tschernyavsky, Sylvia J., Woodruff, James M., Jungbluth, Achim A., Brennan, Murray F., Ladanyi, Marc
Clear cell sarcoma (CCS), also known as melanoma of soft parts, is an uncommon deep soft tissue tumor presenting typically in the lower extremities of young adults. Previous cytogenetic studies have...
Lal, Priti, Salazar, Paulo A., Ladanyi, Marc, Chen, Beiyun
Her-2/neu, a proto-oncogene located on chromosome 17, is an important biomarker in breast carcinoma. Immunohistochemistry (IHC) is currently the most widely used method for assessing Her-2/neu...
Amplification of the MYC Gene in Osteosarcoma Secondary to Paget's Disease of Bone
Ueda, Takafumi, Healey, John H., Huvos, Andrew G., Ladanyi, Marc
Purpose. In a previous series of 25 human osteosarcoma samples studied for MYC gene amplification, we found amplification in two cases (8%), including one arising in association with Paget's disease...
Bean, James, Brennan, Cameron, Shih, Jin-Yuan, Riely, Gregory, Viale, Agnes, Wang, Lu, ...
In human lung adenocarcinomas harboring EGFR mutations, a second-site point mutation that substitutes methionine for threonine at position 790 (T790M) is associated with approximately half of cases...
Functional Copy-Number Alterations in Cancer
Taylor, Barry S., Barretina, Jordi, Socci, Nicholas D., DeCarolis, Penelope, Ladanyi, Marc, Meyerson, Matthew, ...
Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw data about chromosomal aberrations in tumor samples....
Wang, Lu, Bhargava, Rohit, Zheng, Tao, Wexler, Leonard, Collins, Margaret H., Roulston, Diane, ...
Ewing family tumors (EFTs) are prototypical primitive small round blue cell sarcomas arising in bone or extraskeletal soft tissues in children or adolescents. EFTs show fusions of EWS with a gene of...