Marc J. van de Vijver

SIRAC: Supervised Identification of Regions of Aberration in aCGH datasets (2007)

Lai, Carmen, Horlings, Hugo M, Van De Vijver, Marc J, Van Beers, Eric H, Nederlof, Petra M, Wessels, Lodewyk FA, ...

Abstract Background Array comparative genome hybridization (aCGH) provides information about genomic aberrations. Alterations in the DNA copy number may cause the cell to malfunction, leading to...

Efficacy of adjuvant chemotherapy according to hormone receptor status in young patients with breast cancer: a pooled analysis (2007)

Van Der Hage, Jos A, Mieog, J, Van De Vijver, Marc J, Van De Velde, Cornelis JH, Cooperating Investigators Of The European Organization For Research And Treatment Of Cancer

Abstract Introduction Breast cancer at a young age is associated with an unfavorable prognosis. Very young patients with breast cancer therefore are advised to undergo adjuvant chemotherapy...

Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas (2007)

Kreike, Bas, Van Kouwenhove, Marieke, Horlings, Hugo, Weigelt, Britta, Peterse, Hans, Bartelink, Harry, ...

Abstract Introduction Breast cancer is a heterogeneous group of tumors, and can be subdivided on the basis of histopathological features, genetic alterations and gene-expression profiles. One...

Classification of ductal carcinoma in situby gene expression profiling (2006)

Hannemann, Juliane, Velds, Arno, Halfwerk, Johannes BG, Kreike, Bas, Peterse, Johannes L, Van De Vijver, Marc J

Abstract Introduction Ductal carcinoma in situ (DCIS) is characterised by the intraductal proliferation of malignant epithelial cells. Several histological classification systems have been developed,...

Predicting a local recurrence after breast-conserving therapy by gene expression profiling (2006)

Nuyten, Dimitry SA, Kreike, Bas, Hart, Augustinus AM, Chi, Jen-Tsan, Sneddon, Julie B, Wessels, Lodewyk FA, ...

Abstract Introduction To tailor local treatment in breast cancer patients there is a need for predicting ipsilateral recurrences after breast-conserving therapy. After adequate treatment (excision...

The diagnosis and management of pre-invasive breast disease: Pathological diagnosis – problems with existing classifications (2003)

Van De Vijver, Marc J, Peterse, Hans

Abstract In this review, we comment on the reasons for disagreement in the concepts, diagnosis and classifications of pre-invasive intraductal proliferations. In view of these disagreements, our...

The pathology of familial breast cancer: The pre-BRCA1/BRCA2 era - historical perspectives (1999)

Van De Vijver, Marc J

Abstract A proportion of breast carcinomas develop as a result of a genetic predispostion to the disease. Prior to cloning of the BRCA1 and BRCA2 genes a limited number of studies were carried out to...

The pathology of familial breast cancer: The pre-BRCA1/BRCA2 era - historical perspectives

Van De Vijver, Marc J

A proportion of breast carcinomas develop as a result of a genetic predispostion to the disease. Prior to cloning of the BRCA1 and BRCA2 genes a limited number of studies were carried out to identify...

The diagnosis and management of pre-invasive breast disease: Pathological diagnosis – problems with existing classifications

Van De Vijver, Marc J, Peterse, Hans

In this review, we comment on the reasons for disagreement in the concepts, diagnosis and classifications of pre-invasive intraductal proliferations. In view of these disagreements, our proposal is...

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, Jen-Tsan, Wang, Zhen, Nuyten, Dimitry S. A, Rodriguez, Edwin H, Schaner, Marci E, Salim, Ali, ...

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and...

The pathology of familial breast cancer: The pre-BRCA1/BRCA2 era - historical perspectives

Van De Vijver, Marc J

A proportion of breast carcinomas develop as a result of a genetic predispostion to the disease. Prior to cloning of the BRCA1 and BRCA2 genes a limited number of studies were carried out to identify...

The diagnosis and management of pre-invasive breast disease: Pathological diagnosis – problems with existing classifications

Van De Vijver, Marc J, Peterse, Hans

In this review, we comment on the reasons for disagreement in the concepts, diagnosis and classifications of pre-invasive intraductal proliferations. In view of these disagreements, our proposal is...

Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

Chang, Howard Y., Nuyten, Dimitry S. A., Sneddon, Julie B., Hastie, Trevor, Tibshirani, Robert, Sørlie, Therese, ...

Based on the hypothesis that features of the molecular program of normal wound healing might play an important role in cancer metastasis, we previously identified consistent features in the...

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, Jen-Tsan, Wang, Zhen, Nuyten, Dimitry S. A, Rodriguez, Edwin H, Schaner, Marci E, Salim, Ali, ...

The transcriptional response to hypoxia varies between cell types. A gene-expression signature of the cellular response to hypoxia is associated with a significantly poorer prognosis in breast and...

Gene Expression Programs of Human Smooth Muscle Cells: Tissue-Specific Differentiation and Prognostic Significance in Breast Cancers

Chi, Jen-Tsan, Rodriguez, Edwin H, Wang, Zhen, Nuyten, Dimitry S. A, Mukherjee, Sayan, Van De Rijn, Matt, ...

Smooth muscle is present in a wide variety of anatomical locations, such as blood vessels, various visceral organs, and hair follicles. Contraction of smooth muscle is central to functions as diverse...

The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans

Welm, Alana L., Sneddon, Julie B., Taylor, Carmen, Nuyten, Dimitry S. A., Van De Vijver, Marc J., Hasegawa, Bruce H., ...

A better understanding of tumor metastasis requires development of animal models that authentically reproduce the metastatic process. By modifying an existing mouse model of breast cancer, we...