Dating the time of viral subtype divergence (2008)
O'Brien, John D, She, Zhen-Su, Suchard, Marc A
Abstract Precise dating of viral subtype divergence enables researchers to correlate divergence with geographic and demographic occurrences. When historical data are absent (that is, the overwhelming...
Incorporating indel information into phylogeny estimation for rapidly emerging pathogens (2007)
Redelings, Benjamin D, Suchard, Marc A
Abstract Background Phylogenies of rapidly evolving pathogens can be difficult to resolve because of the small number of substitutions that accumulate in the short times since divergence. To improve...
Validation of Candidate Serum Ovarian Cancer Biomarkers for Early Detection (2007)
Feng Su, Jennifer Lang, Ashutosh Kumar, Carey Ng, Brian Hsieh, Marc A. Suchard, ...
Objective: We have previously analyzed protein profi les using Surface Enhanced Laser Desorption and Ionization Time-Of-Flight Mass Spectroscopy (SELDI-TOF-MS) [Kozak et al. 2003, Proc. Natl. Acad....
Michael S. Milane, Marc A. Suchard, Ma-Li Wong, Julio Licinio
An association has been shown between the introduction of the antidepressant fluoxetine in the USA in 1988 and a reduction in the number of suicides.
Michael S. Milane, Marc A. Suchard, Ma-Li Wong, Julio Licinio
BackgroundTo study the potential association of antidepressant use and suicide at a population level, we analyzed the associations between suicide rates and dispensing of the prototypic SSRI...
Oh Brother, Where Art Thou? - A Bayes Factor Test for Recombination with Uncertain Heritage (2001)
Marc A. Suchard, Robert E. Weiss, Karin S. Dorman, Janet S. Sinsheimer
Current methods to identify recombination between genetic variants of human immunodeciency virus-1 (HIV-1) fall into a sequential testing trap, in which signicance is assessed conditional on the...
Are You My Mother? Inferring Parentals for Recombination and Spatial Phylogenetic Variation (2001)
Marc A. Suchard, Robert E. Weiss, Karin S. Dorman, Janet S. Sinsheimer
We develop a Bayesian multiple change-point model to infer spatial phylogenetic variation (SPV) along aligned molecular sequence data. SPV occurs in sequences from organisms that have undergone...
Evolutionary Similarity Among Genes in Primate Sex Determination (2001)
Marc A. Suchard, Robert E. Weiss, Karin S. Dorman, Megha Patel, Janet S. Sinsheimer, ...
Evolutionary Similarity occurs when the branching patterns and relative branch lengths in evolutionary histories from different genes are the same or nearly the same across a set of organisms....
Marc A. Suchard, Robert E. Weiss, Karin S. Dorman, Megha Patel, Janet S. Sinsheimer, ...
Evolutionary Similarity occurs when the branching patterns and relative branch lengths in evolutionary histories from different genes are the same or nearly the same across a set of organisms....
Haake, David A., Suchard, Marc A., Kelley, Melissa M., Dundoo, Manjula, Alt, David P., Zuerner, Richard L.
Leptospires belong to a genus of parasitic bacterial spirochetes that have adapted to a broad range of mammalian hosts. Mechanisms of leptospiral molecular evolution were explored by sequence...
Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity
Yildiz, Bulent O., Suchard, Marc A., Wong, Ma-Li, McCann, Samuel M., Licinio, Julio
Ghrelin plays a key role in the regulation of growth hormone secretion and energy homeostasis. Adiponectin is exclusively secreted by adipose tissue and is abundantly present in the circulation, with...
Kitchen, Christina M. R., Philpott, Sean, Burger, Harold, Weiser, Barbara, Anastos, Kathryn, Suchard, Marc A.
There is substantial evidence for ongoing replication and evolution of human immunodeficiency virus type 1 (HIV-1), even in individuals receiving highly active antiretroviral therapy. Viral evolution...
Liao, Joseph C., Mastali, Mitra, Gau, Vincent, Suchard, Marc A., Møller, Annette K., Bruckner, David A., ...
We describe the first species-specific detection of bacterial pathogens in human clinical fluid samples using a microfabricated electrochemical sensor array. Each of the 16 sensors in the array...
Modeling of the Temporal Patterns of Fluoxetine Prescriptions and Suicide Rates in the United States
Milane, Michael S, Suchard, Marc A, Wong, Ma-Li, Licinio, Julio
An association has been shown between the introduction of the antidepressant fluoxetine in the USA in 1988 and a reduction in the number of suicides.
Stochastic Models for Horizontal Gene Transfer: Taking a Random Walk Through Tree Space
Horizontal gene transfer (HGT) plays a critical role in evolution across all domains of life with important biological and medical implications. I propose a simple class of stochastic models to...
Haake, David A., Suchard, Marc A., Kelley, Melissa M., Dundoo, Manjula, Alt, David P., Zuerner, Richard L.
Leptospires belong to a genus of parasitic bacterial spirochetes that have adapted to a broad range of mammalian hosts. Mechanisms of leptospiral molecular evolution were explored by sequence...
Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity
Yildiz, Bulent O., Suchard, Marc A., Wong, Ma-Li, McCann, Samuel M., Licinio, Julio
Ghrelin plays a key role in the regulation of growth hormone secretion and energy homeostasis. Adiponectin is exclusively secreted by adipose tissue and is abundantly present in the circulation, with...
Kitchen, Christina M. R., Philpott, Sean, Burger, Harold, Weiser, Barbara, Anastos, Kathryn, Suchard, Marc A.
There is substantial evidence for ongoing replication and evolution of human immunodeficiency virus type 1 (HIV-1), even in individuals receiving highly active antiretroviral therapy. Viral evolution...
Liao, Joseph C., Mastali, Mitra, Gau, Vincent, Suchard, Marc A., Møller, Annette K., Bruckner, David A., ...
We describe the first species-specific detection of bacterial pathogens in human clinical fluid samples using a microfabricated electrochemical sensor array. Each of the 16 sensors in the array...
Stochastic Models for Horizontal Gene Transfer: Taking a Random Walk Through Tree Space
Horizontal gene transfer (HGT) plays a critical role in evolution across all domains of life with important biological and medical implications. I propose a simple class of stochastic models to...
Modeling of the Temporal Patterns of Fluoxetine Prescriptions and Suicide Rates in the United States
Milane, Michael S, Suchard, Marc A, Wong, Ma-Li, Licinio, Julio
An association has been shown between the introduction of the antidepressant fluoxetine in the USA in 1988 and a reduction in the number of suicides.
Minin, Vladimir N., Dorman, Karin S., Fang, Fang, Suchard, Marc A.
We present a Bayesian framework for inferring spatial preferences of recombination from multiple putative recombinant nucleotide sequences. Phylogenetic recombination detection has been an active...
Stevenson, Brian, Choy, Henry A., Pinne, Marija, Rotondi, Matthew L., Miller, M. Clarke, DeMoll, Edward, ...
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues. Infectious leptospires are resistant to...
Development of an Advanced Electrochemical DNA Biosensor for Bacterial Pathogen Detection
Liao, Joseph C., Mastali, Mitra, Li, Yang, Gau, Vincent, Suchard, Marc A., Babbitt, Jane, ...
Electrochemical sensors have the capacity for rapid and accurate detection of a wide variety of target molecules in biological fluids. We have developed an electrochemical sensor assay involving...
Evolutionary Similarity Among Genes
Suchard, Marc A., Weiss, Robert E., Sinsheimer, Janet S., Dorman, Karin S., Patel, Megha, McCabe, Edward R.B.
Dating the time of viral subtype divergence
O'Brien, John D, She, Zhen-Su, Suchard, Marc A
Precise dating of viral subtype divergence enables researchers to correlate divergence with geographic and demographic occurrences. When historical data are absent (that is, the overwhelming...