Moxley, Rodney A., Berberov, Emil M., Francis, David H., Xing, Jun, Moayeri, Mahtab, Welsch, Rodney A., ...
Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would...
Typescript.
Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin (hlyA) Mutant in Gnotobiotic Piglets†
Moxley, Rodney A., Berberov, Emil M., Francis, David H., Xing, Jun, Moayeri, Mahtab, Welch, Rodney A., ...
Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would...
Anthrax lethal factor represses glucocorticoid and progesterone receptor activity
Webster, Jeanette I., Tonelli, Leonardo H., Moayeri, Mahtab, Simons, S. Stoney, Leppla, Stephen H., Sternberg, Esther M.
We report here that a bacterial toxin, anthrax lethal toxin (LeTx), at very low concentrations represses glucocorticoid receptor (GR) transactivation in a transient transfection system and the...
Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice
Moayeri, Mahtab, Haines, Diana, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is the major virulence factor of anthrax and reproduces most of the laboratory manifestations of the disease in animals. We studied LT toxicity in BALB/cJ and...
Moayeri, Mahtab, Martinez, Nathaniel W., Wiggins, Jason, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages (Mφ) derived from certain inbred strains. We used nine inbred strains and two...
Koya, Vijay, Moayeri, Mahtab, Leppla, Stephen H., Daniell, Henry
The currently available human vaccine for anthrax, derived from the culture supernatant of Bacillus anthracis, contains the protective antigen (PA) and traces of the lethal and edema factors, which...
Endocrine Perturbation Increases Susceptibility of Mice to Anthrax Lethal Toxin
Moayeri, Mahtab, Webster, Jeanette I., Wiggins, Jason F., Leppla, Stephen H., Sternberg, Esther M.
Bacillus anthracis lethal toxin (LT) causes vascular collapse and high lethality in BALB/cJ mice, intermediate lethality in C57BL/6J mice, and no lethality in DBA/2J mice. We found that...
Karginov, Vladimir A., Nestorovich, Ekaterina M., Moayeri, Mahtab, Leppla, Stephen H., Bezrukov, Sergey M.
Bacillus anthracis secretes three polypeptides: protective antigen (PA), lethal factor (LF), and edema factor (EF), which interact at the surface of mammalian cells to form toxic complexes. LF and EF...
Anthrax Lethal Toxin Induces Ketotifen-Sensitive Intradermal Vascular Leakage in Certain Inbred Mice
Gozes, Yehoshua, Moayeri, Mahtab, Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is a bipartite toxin composed of protective antigen (PA) and lethal factor (LF). Injection of LT produces clinical signs characteristic of anthrax infection,...
Oxidized ATP Protection against Anthrax Lethal Toxin
Moayeri, Mahtab, Wickliffe, Katherine E., Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) induces rapid lysis (
Cisplatin Inhibition of Anthrax Lethal Toxin
Moayeri, Mahtab, Wiggins, Jason F., Lindeman, Robin E., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component,...
Pathogenicity of an Enterotoxigenic Escherichia coli Hemolysin (hlyA) Mutant in Gnotobiotic Piglets†
Moxley, Rodney A., Berberov, Emil M., Francis, David H., Xing, Jun, Moayeri, Mahtab, Welch, Rodney A., ...
Pigs infected with hemolytic F4+ strains of enterotoxigenic Escherichia coli often develop septicemia secondary to intestinal infection. We tested the hypothesis that inactivation of hemolysin would...
Anthrax lethal factor represses glucocorticoid and progesterone receptor activity
Webster, Jeanette I., Tonelli, Leonardo H., Moayeri, Mahtab, Simons, S. Stoney, Leppla, Stephen H., Sternberg, Esther M.
We report here that a bacterial toxin, anthrax lethal toxin (LeTx), at very low concentrations represses glucocorticoid receptor (GR) transactivation in a transient transfection system and the...
Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice
Moayeri, Mahtab, Haines, Diana, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is the major virulence factor of anthrax and reproduces most of the laboratory manifestations of the disease in animals. We studied LT toxicity in BALB/cJ and...
Moayeri, Mahtab, Martinez, Nathaniel W., Wiggins, Jason, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages (Mφ) derived from certain inbred strains. We used nine inbred strains and two...
Endocrine Perturbation Increases Susceptibility of Mice to Anthrax Lethal Toxin
Moayeri, Mahtab, Webster, Jeanette I., Wiggins, Jason F., Leppla, Stephen H., Sternberg, Esther M.
Bacillus anthracis lethal toxin (LT) causes vascular collapse and high lethality in BALB/cJ mice, intermediate lethality in C57BL/6J mice, and no lethality in DBA/2J mice. We found that...
Karginov, Vladimir A., Nestorovich, Ekaterina M., Moayeri, Mahtab, Leppla, Stephen H., Bezrukov, Sergey M.
Bacillus anthracis secretes three polypeptides: protective antigen (PA), lethal factor (LF), and edema factor (EF), which interact at the surface of mammalian cells to form toxic complexes. LF and EF...
Koya, Vijay, Moayeri, Mahtab, Leppla, Stephen H., Daniell, Henry
The currently available human vaccine for anthrax, derived from the culture supernatant of Bacillus anthracis, contains the protective antigen (PA) and traces of the lethal and edema factors, which...
Anthrax Lethal Toxin Induces Ketotifen-Sensitive Intradermal Vascular Leakage in Certain Inbred Mice
Gozes, Yehoshua, Moayeri, Mahtab, Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is a bipartite toxin composed of protective antigen (PA) and lethal factor (LF). Injection of LT produces clinical signs characteristic of anthrax infection,...
Oxidized ATP Protection against Anthrax Lethal Toxin
Moayeri, Mahtab, Wickliffe, Katherine E., Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) induces rapid lysis (
Cisplatin Inhibition of Anthrax Lethal Toxin
Moayeri, Mahtab, Wiggins, Jason F., Lindeman, Robin E., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component,...
Bacillus anthracis Edema Toxin Causes Extensive Tissue Lesions and Rapid Lethality in Mice
Firoved, Aaron M., Miller, Georgina F., Moayeri, Mahtab, Kakkar, Rahul, Shen, Yuequan, Wiggins, Jason F., ...
Bacillus anthracis edema toxin (ET), an adenylyl cyclase, is an important virulence factor that contributes to anthrax disease. The role of ET in anthrax pathogenesis is, however, poorly understood....
Anthrax Edema Toxin Sensitizes DBA/2J Mice to Lethal Toxin▿
Firoved, Aaron M., Moayeri, Mahtab, Wiggins, Jason F., Shen, Yuequan, Tang, Wei-Jen, Leppla, Stephen H.
Anthrax toxin is made up of three separate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal factor (LF). EF...
Anthrax Protective Antigen Cleavage and Clearance from the Blood of Mice and Rats▿
Moayeri, Mahtab, Wiggins, Jason F., Leppla, Stephen H.
Bacillus anthracis protective antigen (PA) is an 83-kDa (PA83) protein that is cleaved to the 63-kDa protein (PA63) as an essential step in binding and internalizing lethal factor (LF). To assess in...
Role of N-Terminal Amino Acids in the Potency of Anthrax Lethal Factor
Gupta, Pradeep K., Moayeri, Mahtab, Crown, Devorah, Fattah, Rasem J., Leppla, Stephen H.
Anthrax lethal factor (LF) is a Zn+2-dependent metalloprotease that cleaves several MAPK kinases and is responsible for the lethality of anthrax lethal toxin (LT). We observed that a recombinant LF...
In Vivo Efficacy of β-Cyclodextrin Derivatives against Anthrax Lethal Toxin▿
Moayeri, Mahtab, Robinson, Tanisha M., Leppla, Stephen H., Karginov, Vladimir A.
We evaluated the in vivo efficacy of three β-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described...