Magda N. Kosmopoulou

Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs

Oikonomakos, Nikos G., Kosmopoulou, Magda N., Chrysina, Evangelia D., Leonidas, Demetres D., Kostas, Ioannis D., Wendt, K. Ulrich, ...

Acyl ureas were discovered as a novel class of inhibitors for glycogen phosphorylase, a molecular target to control hyperglycemia in type 2 diabetics. This series is exemplified by 6-{2,6-Dichloro-...

Kinetic and crystallographic studies on 2-(β-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site

Chrysina, Evangelia D., Kosmopoulou, Magda N., Tiraidis, Constantinos, Kardakaris, Rozina, Bischler, Nicolas, Leonidas, Demetres D., ...

In an attempt to identify leads that would enable the design of inhibitors with enhanced affinity for glycogen phosphorylase (GP), that might control hyperglycaemia in type 2 diabetes, three new...

High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors

Leonidas, Demetres D., Chavali, Gayatri B., Oikonomakos, Nikos G., Chrysina, Evangelia D., Kosmopoulou, Magda N., Vlassi, Metaxia, ...

The crystal structures of bovine pancreatic ribonuclease A (RNase A) in complex with 3′,5′-ADP, 2′,5′-ADP, 5′-ADP, U-2′-p and U-3′-p have been determined at high resolution. The...