Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...
Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...
Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9▿ †
Gyrd-Hansen, Mads, Farkas, Thomas, Fehrenbacher, Nicole, Bastholm, Lone, Høyer-Hansen, Maria, Elling, Folmer, ...
The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically...
Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, ...
Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by...