The yeast kinome displays scale free topology with functional hub clusters (2005)
Lee, Robin EC, Megeney, Lynn A
Abstract Background The availability of interaction databases provides an opportunity for researchers to utilize immense amounts of data exclusively in silico . Recently there has been an emphasis on...
Severe cardiomyopathy in mice lacking dystrophin and MyoD
Megeney, Lynn A., Kablar, Boris, Perry, Robert L. S., Ying, Chuyan, May, Linda, Rudnicki, Michael A.
The mdx mouse, a mouse model of Duchenne muscular dystrophy, carries a loss-of-function mutation in dystrophin, a component of the membrane-associated dystrophin–glycoprotein complex. Unlike...
LeCouter, Jennifer E., Kablar, Boris, Hardy, W. Rodney, Ying, Chuyan, Megeney, Lynn A., May, Linda L., ...
To investigate the function of the Rb-related p107 gene, a null mutation in p107 was introduced into the germ line of mice and bred into a BALB/cJ genetic background. Mice lacking p107 were viable...
Caspase 3 activity is required for skeletal muscle differentiation
Fernando, Pasan, Kelly, John F., Balazsi, Kim, Slack, Ruth S., Megeney, Lynn A.
The cellular alterations associated with skeletal muscle differentiation share a high degree of similarity with key phenotypic changes usually ascribed to apoptosis. For example, actin fiber...
Chakkalakal, Joe V., Stocksley, Mark A., Harrison, Mary-Ann, Angus, Lindsay M., Deschênes-Furry, Julie, St-Pierre, Simon, ...
Utrophin levels have recently been shown to be more abundant in slow vs. fast muscles, but the nature of the molecular events underlying this difference remains to be fully elucidated. Here, we...
Severe cardiomyopathy in mice lacking dystrophin and MyoD
Megeney, Lynn A., Kablar, Boris, Perry, Robert L. S., Ying, Chuyan, May, Linda, Rudnicki, Michael A.
The mdx mouse, a mouse model of Duchenne muscular dystrophy, carries a loss-of-function mutation in dystrophin, a component of the membrane-associated dystrophin–glycoprotein complex. Unlike...
LeCouter, Jennifer E., Kablar, Boris, Hardy, W. Rodney, Ying, Chuyan, Megeney, Lynn A., May, Linda L., ...
To investigate the function of the Rb-related p107 gene, a null mutation in p107 was introduced into the germ line of mice and bred into a BALB/cJ genetic background. Mice lacking p107 were viable...
Caspase 3 activity is required for skeletal muscle differentiation
Fernando, Pasan, Kelly, John F., Balazsi, Kim, Slack, Ruth S., Megeney, Lynn A.
The cellular alterations associated with skeletal muscle differentiation share a high degree of similarity with key phenotypic changes usually ascribed to apoptosis. For example, actin fiber...
Chakkalakal, Joe V., Stocksley, Mark A., Harrison, Mary-Ann, Angus, Lindsay M., Deschênes-Furry, Julie, St-Pierre, Simon, ...
Utrophin levels have recently been shown to be more abundant in slow vs. fast muscles, but the nature of the molecular events underlying this difference remains to be fully elucidated. Here, we...
A Non-Death Role of the Yeast Metacaspase: Yca1p Alters Cell Cycle Dynamics
Lee, Robin E. C., Puente, Lawrence G., Kærn, Mads, Megeney, Lynn A.
Caspase proteases are a conserved protein family predominantly known for engaging and executing apoptotic cell death. Nevertheless, in higher eukaryotes, caspases also influence a variety of cell...