Lyndle Gradoville

A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus

Sun, Ren, Lin, Su-Fang, Gradoville, Lyndle, Yuan, Yan, Zhu, Fanxiu, Miller, George

Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight...

Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression

Sun, Ren, Lin, Su-Fang, Staskus, Katherine, Gradoville, Lyndle, Grogan, Elizabeth, Haase, Ashley, ...

Herpesvirus gene expression can be classified into four distinct kinetic stages: latent, immediate early, early, and late. Here we characterize the kinetic class of a group of 16 Kaposi’s...

Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50/Rta Protein Activates the Entire Viral Lytic Cycle in the HH-B2 Primary Effusion Lymphoma Cell Line†

Gradoville, Lyndle, Gerlach, Jennifer, Grogan, Elizabeth, Shedd, Duane, Nikiforow, Sarah, Metroka, Craig, ...

Rta, the gene product of Kaposi's sarcoma-associated herpesvirus (KSHV) encoded mainly in open reading frame 50 (ORF50), is capable of activating expression of viral lytic cycle genes. What was not...

Protein Kinase C-Independent Activation of the Epstein-Barr Virus Lytic Cycle

Gradoville, Lyndle, Kwa, David, El-Guindy, Ayman, Miller, George

The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a...

A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus

Sun, Ren, Lin, Su-Fang, Gradoville, Lyndle, Yuan, Yan, Zhu, Fanxiu, Miller, George

Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight...

Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression

Sun, Ren, Lin, Su-Fang, Staskus, Katherine, Gradoville, Lyndle, Grogan, Elizabeth, Haase, Ashley, ...

Herpesvirus gene expression can be classified into four distinct kinetic stages: latent, immediate early, early, and late. Here we characterize the kinetic class of a group of 16 Kaposi’s...

Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50/Rta Protein Activates the Entire Viral Lytic Cycle in the HH-B2 Primary Effusion Lymphoma Cell Line†

Gradoville, Lyndle, Gerlach, Jennifer, Grogan, Elizabeth, Shedd, Duane, Nikiforow, Sarah, Metroka, Craig, ...

Rta, the gene product of Kaposi's sarcoma-associated herpesvirus (KSHV) encoded mainly in open reading frame 50 (ORF50), is capable of activating expression of viral lytic cycle genes. What was not...

Protein Kinase C-Independent Activation of the Epstein-Barr Virus Lytic Cycle

Gradoville, Lyndle, Kwa, David, El-Guindy, Ayman, Miller, George

The protein kinase C (PKC) pathway has been considered to be essential for activation of latent Epstein-Barr virus (EBV) into the lytic cycle. The phorbol ester tetradecanoyl phorbol acetate (TPA), a...

De Novo Protein Synthesis Is Required for Lytic Cycle Reactivation of Epstein-Barr Virus, but Not Kaposi's Sarcoma-Associated Herpesvirus, in Response to Histone Deacetylase Inhibitors and Protein Kinase C Agonists▿

Ye, Jianjiang, Gradoville, Lyndle, Daigle, Derek, Miller, George

The oncogenic human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are latent in cultured lymphoma cells. We asked whether reactivation from latency...

Histone Hyperacetylation Occurs on Promoters of Lytic Cycle Regulatory Genes in Epstein-Barr Virus-Infected Cell Lines Which Are Refractory to Disruption of Latency by Histone Deacetylase Inhibitors▿

Countryman, Jill K., Gradoville, Lyndle, Miller, George

Activation of the Epstein-Barr virus (EBV) lytic cycle is mediated through the combined actions of ZEBRA and Rta, the products of the viral BZLF1 and BRLF1 genes. During latency, these two genes are...