Lyn-Marie Birkholtz

Heterologous expression of plasmodial proteins for structural studies and functional annotation (2008)

Birkholtz, Lyn-Marie, Blatch, Gregory, Coetzer, Theresa L, Hoppe, Heinrich C, Human, Esmaré, Morris, Elizabeth J, ...

Abstract Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2008)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2008)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2008)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

Deletion mutagenesis of large areas in Plasmodium falciparumgenes: a comparative study (2007)

Williams, Marni, Louw, Abraham I, Birkholtz, Lyn-Marie

Abstract Background The increasing emergence of Plasmodium falciparum parasites resistant to most of the cost-effective drugs has necessitated the identification of novel leads and drug targets....

Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase (2007)

Burger, Pieter Buys, Birkholtz, Lyn-Marie, Joubert, Fourie, Haider, Nashya, Walter, Rolf D., Louw, Abraham I.

Spermidine synthase is currently considered as a promising drug target in the malaria parasite, Plasmodium falciparum, due to the vital role of spermidine in the activation of the eukaryotic...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? (2006)

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

Abstract The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a...

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

Birkholtz, Lyn-Marie, Wrenger, Carsten, Joubert, Fourie, Wells, Gordon A, Walter, Rolf D, Louw, Abraham I

Polyamine biosynthesis of the malaria parasite, Plasmodium falciparum, is regulated by a single, hinge-linked bifunctional PfAdoMetDC/ODC [ P. falciparum AdoMetDC (S-adenosylmethionine...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.

Birkholtz, Lyn-Marie, Wrenger, Carsten, Joubert, Fourie, Wells, Gordon A, Walter, Rolf D, Louw, Abraham I

Polyamine biosynthesis of the malaria parasite, Plasmodium falciparum, is regulated by a single, hinge-linked bifunctional PfAdoMetDC/ODC [ P. falciparum AdoMetDC (S-adenosylmethionine...

Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space?

Birkholtz, Lyn-Marie, Bastien, Olivier, Wells, Gordon, Grando, Delphine, Joubert, Fourie, Kasam, Vinod, ...

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term,...

Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study

Williams, Marni, Louw, Abraham I, Birkholtz, Lyn-Marie

Heterologous expression of plasmodial proteins for structural studies and functional annotation

Birkholtz, Lyn-Marie, Blatch, Gregory, Coetzer, Theresa L, Hoppe, Heinrich C, Human, Esmaré, Morris, Elizabeth J, ...

Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites to the...