Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply
Schweizer, Ulrich, Streckfuß, Florian, Pelt, Paco, Carlson, Bradley A., Hatfield, Dolph L., Köhrle, Josef, ...
Liver-specific inactivation of Trsp, the gene for selenocysteine tRNA, removes SePP (selenoprotein P) from plasma, causing serum selenium levels to fall from 298 μg/l to 50 μg/l and kidney...
Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
Schomburg, Lutz, Schweizer, Ulrich, Holtmann, Bettina, Flohé, Leopold, Sendtner, Michael, Köhrle, Josef
Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable,...
Schweizer, Ulrich, Michaelis, Marten, Köhrle, Josef, Schomburg, Lutz
Mice deficient in selenoprotein P exhibit a disturbed selenium distribution and reduced activities of other selenoenzymes and display defects in growth and motor co-ordination. We have normalized...
Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply
Schweizer, Ulrich, Streckfuß, Florian, Pelt, Paco, Carlson, Bradley A., Hatfield, Dolph L., Köhrle, Josef, ...
Liver-specific inactivation of Trsp, the gene for selenocysteine tRNA, removes SePP (selenoprotein P) from plasma, causing serum selenium levels to fall from 298 μg/l to 50 μg/l and kidney...
Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues.
Schomburg, Lutz, Schweizer, Ulrich, Holtmann, Bettina, Flohé, Leopold, Sendtner, Michael, Köhrle, Josef
Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable,...
Schweizer, Ulrich, Michaelis, Marten, Köhrle, Josef, Schomburg, Lutz
Mice deficient in selenoprotein P exhibit a disturbed selenium distribution and reduced activities of other selenoenzymes and display defects in growth and motor co-ordination. We have normalized...