Luk Van Parijs

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells (2002)

Yang, Lili, Qin, Xiao-Feng, Baltimore, David, Van Parijs, Luk

We have developed an alternative to transgenesis for producing antigen-specific T cells in vivo. In this system, clonal naive T cells with defined antigen specificity are generated by...

Mechanisms of peripheral CD4⁺ T cell tolerance /--a thesis presented by Luk Van Parijs. (1997)

Van Parijs, Luk.

Thesis (Ph. D.)--Harvard University, 1997.

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells

Yang, Lili, Qin, Xiao-Feng, Baltimore, David, Van Parijs, Luk

We have developed an alternative to transgenesis for producing antigen-specific T cells in vivo. In this system, clonal naive T cells with defined antigen specificity are generated by...

Cre-lox-regulated conditional RNA interference from transgenes

Ventura, Andrea, Meissner, Alexander, Dillon, Christopher P., McManus, Michael, Sharp, Phillip A., Van Parijs, Luk, ...

We have generated two lentiviral vectors for conditional, Cre-lox-regulated, RNA interference. One vector allows for conditional activation, whereas the other permits conditional inactivation of...

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells

Yang, Lili, Qin, Xiao-Feng, Baltimore, David, Van Parijs, Luk

We have developed an alternative to transgenesis for producing antigen-specific T cells in vivo. In this system, clonal naive T cells with defined antigen specificity are generated by...

Cre-lox-regulated conditional RNA interference from transgenes

Ventura, Andrea, Meissner, Alexander, Dillon, Christopher P., McManus, Michael, Sharp, Phillip A., Van Parijs, Luk, ...

We have generated two lentiviral vectors for conditional, Cre-lox-regulated, RNA interference. One vector allows for conditional activation, whereas the other permits conditional inactivation of...

Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

Zheng, Ye, Vig, Monika, Lyons, Jesse, Van Parijs, Luk, Beg, Amer A.

Signaling pathways involved in regulating T cell proliferation and survival are not well understood. Here we have investigated a possible role of the nuclear factor (NF)-κB pathway in regulating...

Interferon γ Is Required for Activation-induced Death of T Lymphocytes

Refaeli, Yosef, Van Parijs, Luk, Alexander, Stephen I., Abbas, Abul K.

The effector cytokine interferon γ (IFN-γ) may play a role in T cell homeostasis. We have examined the requirement for IFN-γ in one mechanism that regulates T cell expansion and survival,...