Luc A. Sabourin

Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region

Sabourin, Luc A., Seale, Patrick, Wagner, Julian, Rudnicki, Michael A.

We have demonstrated that a novel Ste20-related kinase, designated SLK, mediates apoptosis and actin stress fiber dissolution through distinct domains generated by caspase 3 cleavage. Overexpression...

Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region

Sabourin, Luc A., Tamai, Katsuyuki, Seale, Patrick, Wagner, Julian, Rudnicki, Michael A.

FAK/src-Family Dependent Activation of the Ste20-Like Kinase SLK Is Required for Microtubule-Dependent Focal Adhesion Turnover and Cell Migration

Wagner, Simona, Storbeck, Chris J., Roovers, Kristin, Chaar, Ziad Y., Kolodziej, Piotr, McKay, Marlene, ...

Cell migration involves a multitude of signals that converge on cytoskeletal reorganization, essential for development, immune responses and tissue repair. Using knockdown and dominant negative...

Reduced Differentiation Potential of Primary MyoD−/− Myogenic Cells Derived from Adult Skeletal Muscle

Sabourin, Luc A., Girgis-Gabardo, Adele, Seale, Patrick, Asakura, Atsushi, Rudnicki, Michael A.

To gain insight into the regeneration deficit of MyoD−/− muscle, we investigated the growth and differentiation of cultured MyoD−/− myogenic cells. Primary MyoD−/− myogenic cells...