Lowen Y. Lee

Heme oxygenase–1 and carbon monoxide suppress autoimmune neuroinflammation

Chora, Ângelo A., Fontoura, Paulo, Cunha, Andreia, Pais, Teresa F., Cardoso, Sílvia, Ho, Peggy P., ...

Heme oxygenase–1 (HO-1, encoded by HMOX1) dampens inflammatory reactions via the catabolism of heme into CO, Fe, and biliverdin. We report that expression of HO-1 dictates the pathologic outcome of...

Glia-dependent TGF-β signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis

Luo, Jian, Ho, Peggy P., Buckwalter, Marion S., Hsu, Tiffany, Lee, Lowen Y., Zhang, Hui, ...

Autoimmune encephalomyelitis, a mouse model for multiple sclerosis, is characterized by the activation of immune cells, demyelination of axons in the CNS, and paralysis. We found that TGF-β1...

IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice

Thibault, Donna L., Chu, Alvina D., Graham, Kareem L., Balboni, Imelda, Lee, Lowen Y., Kohlmoos, Cassidy, ...

A hallmark of SLE is the production of high-titer, high-affinity, isotype-switched IgG autoantibodies directed against nucleic acid–associated antigens. Several studies have established a role for...