Pellegrino, Maurizio, Provero, Paolo, Silengo, Lorenzo, Di Cunto, Ferdinando
Abstract Background Public repositories of microarray data contain an incredible amount of information that is potentially relevant to explore functional relationships among genes by meta-analysis of...
Paolo Provero, Lorenzo Silengo
Background: Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly e#ected through transcription factors binding to specific recognition motifs located upstream...
Corà, Davide, Di Cunto, Ferdinando, Provero, Paolo, Silengo, Lorenzo, Caselle, Michele
Abstract Background Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly effected through transcription factors binding to specific recognition motifs located...
Cora', Davide, Di Cunto, Ferdinando, Provero, Paolo, Silengo, Lorenzo, Caselle, Michele
BACKGROUND: Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly effected through transcription factors binding to specific recognition motifs located upstream...
β1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function
Retta, S. Francesco, Balzac, Fiorella, Ferraris, Piercarlo, Belkin, Alexey M., Fässler, Reinhard, Humphries, Martin J., ...
The β1-integrin cytoplasmic domain consists of a membrane proximal subdomain common to the four known isoforms (“common” region) and a distal subdomain specific for each isoform (“variable”...
Brizzi, Maria Felice, Defilippi, Paola, Rosso, Arturo, Venturino, Mascia, Garbarino, Giovanni, Miyajima, Atsushi, ...
Integrin-mediated adhesion induces several signaling pathways leading to regulation of gene transcription, control of cell cycle entry and survival from apoptosis. Here we investigate the involvement...
Cross Talk between β1 and αV Integrins: β1 Affects β3 mRNA Stability
Retta, Saverio Francesco, Cassarà, Georgia, D'Amato, Monica, Alessandro, Riccardo, Pellegrino, Maurizio, Degani, Simona, ...
There is increasing evidence that a fine-tuned integrin cross talk can generate a high degree of specificity in cell adhesion, suggesting that spatially and temporally coordinated expression and...
Defective Dendrite Elongation but Normal Fertility in Mice Lacking the Rho-Like GTPase Activator Dbl
Hirsch, Emilio, Pozzato, Michela, Vercelli, Alessandro, Barberis, Laura, Azzolino, Ornella, Russo, Chiara, ...
Dbl is the prototype of a large family of GDP-GTP exchange factors for small GTPases of the Rho family. In vitro, Dbl is known to activate Rho and Cdc42 and to induce a transformed phenotype. Dbl is...
Polypeptide Formation and Polyribosomes in Escherichia coli Treated with Chloramphenicol
Cremer, Kenneth J., Silengo, Lorenzo, Schlessinger, D.
In Escherichia coli cultures maximally inhibited with chloramphenicol, formation of polypeptides still continued at a slow, constant rate for at least 90 min. The rate of leucine incorporation was...
3′,5′-Cyclic Adenosine Monophosphate-Requiring Mutants of Escherichia coli1
Ohnishi, Yoshinari, Silengo, Lorenzo, Kuwano, Michihiko, Schlessinger, David
Mutants that require exogenous 3′,5′-cyclic adenosine monophosphate (cAMP) for exponential growth were isolated from strains deficient in adenyl cyclase. Studies of one strain showed that cAMP is...
Di Stefano, Paola, Cabodi, Sara, Erba, Elisabetta Boeri, Margaria, Valentina, Bergatto, Elena, Giuffrida, Maria Gabriella, ...
Integrin-mediated cell adhesion stimulates a cascade of signaling pathways that control cell proliferation, migration, and survival, mostly through tyrosine phosphorylation of signaling molecules....
β1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function
Retta, S. Francesco, Balzac, Fiorella, Ferraris, Piercarlo, Belkin, Alexey M., Fässler, Reinhard, Humphries, Martin J., ...
The β1-integrin cytoplasmic domain consists of a membrane proximal subdomain common to the four known isoforms (“common” region) and a distal subdomain specific for each isoform (“variable”...
Brizzi, Maria Felice, Defilippi, Paola, Rosso, Arturo, Venturino, Mascia, Garbarino, Giovanni, Miyajima, Atsushi, ...
Integrin-mediated adhesion induces several signaling pathways leading to regulation of gene transcription, control of cell cycle entry and survival from apoptosis. Here we investigate the involvement...
Cross Talk between β1 and αV Integrins: β1 Affects β3 mRNA Stability
Retta, Saverio Francesco, Cassarà, Georgia, D'Amato, Monica, Alessandro, Riccardo, Pellegrino, Maurizio, Degani, Simona, ...
There is increasing evidence that a fine-tuned integrin cross talk can generate a high degree of specificity in cell adhesion, suggesting that spatially and temporally coordinated expression and...
Defective Dendrite Elongation but Normal Fertility in Mice Lacking the Rho-Like GTPase Activator Dbl
Hirsch, Emilio, Pozzato, Michela, Vercelli, Alessandro, Barberis, Laura, Azzolino, Ornella, Russo, Chiara, ...
Dbl is the prototype of a large family of GDP-GTP exchange factors for small GTPases of the Rho family. In vitro, Dbl is known to activate Rho and Cdc42 and to induce a transformed phenotype. Dbl is...
Polypeptide Formation and Polyribosomes in Escherichia coli Treated with Chloramphenicol
Cremer, Kenneth J., Silengo, Lorenzo, Schlessinger, D.
In Escherichia coli cultures maximally inhibited with chloramphenicol, formation of polypeptides still continued at a slow, constant rate for at least 90 min. The rate of leucine incorporation was...
3′,5′-Cyclic Adenosine Monophosphate-Requiring Mutants of Escherichia coli1
Ohnishi, Yoshinari, Silengo, Lorenzo, Kuwano, Michihiko, Schlessinger, David
Mutants that require exogenous 3′,5′-cyclic adenosine monophosphate (cAMP) for exponential growth were isolated from strains deficient in adenyl cyclase. Studies of one strain showed that cAMP is...
Di Stefano, Paola, Cabodi, Sara, Erba, Elisabetta Boeri, Margaria, Valentina, Bergatto, Elena, Giuffrida, Maria Gabriella, ...
Integrin-mediated cell adhesion stimulates a cascade of signaling pathways that control cell proliferation, migration, and survival, mostly through tyrosine phosphorylation of signaling molecules....
Plasma Protein Haptoglobin Modulates Renal Iron Loading
Fagoonee, Sharmila, Gburek, Jakub, Hirsch, Emilio, Marro, Samuele, Moestrup, Soren K., Laurberg, Jacob M., ...
Haptoglobin is the plasma protein with the highest binding affinity for hemoglobin. The strength of hemoglobin binding and the existence of a specific receptor for the haptoglobin-hemoglobin complex...
Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ
Vecchione, Carmine, Patrucco, Enrico, Marino, Gennaro, Barberis, Laura, Poulet, Roberta, Aretini, Alessandra, ...
Hypertension affects nearly 20% of the population in Western countries and strongly increases the risk for cardiovascular diseases. In the pathogenesis of hypertension, the vasoactive peptide of the...
Prediction of Human Disease Genes by Human-Mouse Conserved Coexpression Analysis
Ala, Ugo, Piro, Rosario Michael, Grassi, Elena, Damasco, Christian, Silengo, Lorenzo, Oti, Martin, ...
One of the most limiting aspects of biological research in the post-genomic era is the capability to integrate massive datasets on gene structure and function for producing useful biological...
Belkin, Alexey M., Retta, S. Francesco, Pletjushkina, Olga Y., Balzac, Fiorella, Silengo, Lorenzo, Fassler, Reinhard, ...
Expression of muscle-specific β1D integrin with an alternatively spliced cytoplasmic domain in CHO and GD25, β1 integrin-minus cells leads to their phenotypic conversion. β1D-transfected nonmuscle...
Hirsch, Emilio, Barberis, Laura, Brancaccio, Mara, Azzolino, Ornella, Xu, Dazhong, Kyriakis, John M., ...
Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of β1 integrin leads to defective proliferation and...
Degani, Simona, Balzac, Fiorella, Brancaccio, Mara, Guazzone, Simona, Retta, Saverio Francesco, Silengo, Lorenzo, ...
Using two-hybrid screening, we isolated the integrin cytoplasmic domain-associated protein (ICAP-1), an interactor for the COOH terminal region of the β1A integrin cytoplasmic domain. To investigate...
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity
Di Stefano, Paola, Damiano, Laura, Cabodi, Sara, Aramu, Simona, Tordella, Luca, Praduroux, Alice, ...
We recently identified p140Cap as a novel adaptor protein, expressed in epithelial-rich tissues and phosphorylated upon cell matrix adhesion and growth factor treatment. Here, we characterise p140Cap...