Lloyd B. Klickstein

A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1) (2005)

Repik, Alexander, Pincus, Steve E., Ghiran, Ionita, Nicholson-Weller, Anne, Asher, Damon R., Cerny, Anna M., ...

Complement receptor 1 (CR1) on the surface of human erythrocytes facilitates intravascular clearance of complement-opsonized pathogens. The need for complement activation can be circumvented by...

Specific Activation of Leukocyte β2 Integrins Lymphocyte Function–associated Antigen-1 and Mac-1 by Chemokines Mediated by Distinct Pathways via the α Subunit Cytoplasmic Domains

Weber, Kim S.C., Klickstein, Lloyd B., Weber, Christian

We show that CC chemokines induced a sustained increase in monocyte adhesion to intercellular adhesion molecule-1 that was mediated by Mac-1 (αMβ2) but not lymphocyte function–associated...

Dual Role of H-Ras in Regulation of Lymphocyte Function Antigen-1 Activity by Stromal Cell-derived Factor-1α: Implications for Leukocyte Transmigration

Weber, Kim S.C., Ostermann, Georg, Zernecke, Alma, Schröder, Andreas, Klickstein, Lloyd B., Weber, Christian

We investigated the role of H-Ras in chemokine-induced integrin regulation in leukocytes. Stimulation of Jurkat T cells with the CXC chemokine stromal cell-derived factor-1α (SDF-1α) resulted in a...

The integrin α-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation

Xie, Can, Shimaoka, Motomu, Xiao, Tsan, Schwab, Pascale, Klickstein, Lloyd B., Springer, Timothy A.

Two activation-dependent Abs to the integrin αL-subunit were used to study conformational rearrangement of αLβ2 on the cell surface. Activation lowered the concentration of Ca2+ required for...

Specific Activation of Leukocyte β2 Integrins Lymphocyte Function–associated Antigen-1 and Mac-1 by Chemokines Mediated by Distinct Pathways via the α Subunit Cytoplasmic Domains

Weber, Kim S.C., Klickstein, Lloyd B., Weber, Christian

We show that CC chemokines induced a sustained increase in monocyte adhesion to intercellular adhesion molecule-1 that was mediated by Mac-1 (αMβ2) but not lymphocyte function–associated...

Dual Role of H-Ras in Regulation of Lymphocyte Function Antigen-1 Activity by Stromal Cell-derived Factor-1α: Implications for Leukocyte Transmigration

Weber, Kim S.C., Ostermann, Georg, Zernecke, Alma, Schröder, Andreas, Klickstein, Lloyd B., Weber, Christian

We investigated the role of H-Ras in chemokine-induced integrin regulation in leukocytes. Stimulation of Jurkat T cells with the CXC chemokine stromal cell-derived factor-1α (SDF-1α) resulted in a...

The integrin α-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation

Xie, Can, Shimaoka, Motomu, Xiao, Tsan, Schwab, Pascale, Klickstein, Lloyd B., Springer, Timothy A.

Two activation-dependent Abs to the integrin αL-subunit were used to study conformational rearrangement of αLβ2 on the cell surface. Activation lowered the concentration of Ca2+ required for...

Rituximab for steroid-refractory chronic graft-versus-host disease

Cutler, Corey, Miklos, David, Kim, Haesook T., Treister, Nathaniel, Woo, Sook-Bin, Bienfang, Don, ...

B cells may be implicated in the pathophysiology of chronic graft-versus-host disease (GVHD), as evidenced by antibody production against sex-mismatched, Y chromosome–encoded minor HLA antigens in...

Complement Receptor 1/Cd35 Is a Receptor for Mannan-Binding Lectin

Ghiran, Ionita, Barbashov, Sergi F., Klickstein, Lloyd B., Tas, Sander W., Jensenius, Jens C., Nicholson-Weller, Anne

Mannan-binding lectin (MBL), a member of the collectin family, is known to have opsonic function, although identification of its cellular receptor has been elusive. Complement C1q, which is...