Lisa K. Denzin

Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides

Chervonsky, Alexander V., Medzhitov, Ruslan M., Denzin, Lisa K., Barlow, Avlin K., Rudensky, Alexander Yu., Janeway, Charles A.

Intracellular trafficking of major histocompatibility complex (MHC) class II molecules is characterized by passage through specialized endocytic compartment(s) where antigenic peptides replace...

Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers

Sant'Angelo, Derek B., Cresswell, Peter, Janeway, Charles A., Denzin, Lisa K.

T cell receptor (TCR) allelic exclusion is believed to be primarily mediated by suppression of further recombination at the TCR locus after the expression of a functional TCR protein. Genetic allelic...

Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis

Tolosa, Eva, Li, Weijie, Yasuda, Yoshiyuki, Wienhold, Wolfgang, Denzin, Lisa K., Lautwein, Alfred, ...

Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have...

A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM

Deshaies, Francis, Brunet, Alexandre, Diallo, Djibril A., Denzin, Lisa K., Samaan, Angela, Thibodeau, Jacques

B lymphocytes express the nonclassical class II molecule HLA-DO, which modulates the peptide loading activity of HLA-DM in the endocytic pathway. Binding to HLA-DM is required for HLA-DO to egress...

Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides

Chervonsky, Alexander V., Medzhitov, Ruslan M., Denzin, Lisa K., Barlow, Avlin K., Rudensky, Alexander Yu., Janeway, Charles A.

Intracellular trafficking of major histocompatibility complex (MHC) class II molecules is characterized by passage through specialized endocytic compartment(s) where antigenic peptides replace...

Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers

Sant'Angelo, Derek B., Cresswell, Peter, Janeway, Charles A., Denzin, Lisa K.

T cell receptor (TCR) allelic exclusion is believed to be primarily mediated by suppression of further recombination at the TCR locus after the expression of a functional TCR protein. Genetic allelic...

Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis

Tolosa, Eva, Li, Weijie, Yasuda, Yoshiyuki, Wienhold, Wolfgang, Denzin, Lisa K., Lautwein, Alfred, ...

Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in peripheral APCs have...

A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM

Deshaies, Francis, Brunet, Alexandre, Diallo, Djibril A., Denzin, Lisa K., Samaan, Angela, Thibodeau, Jacques

B lymphocytes express the nonclassical class II molecule HLA-DO, which modulates the peptide loading activity of HLA-DM in the endocytic pathway. Binding to HLA-DM is required for HLA-DO to egress...

Germinal Center B Cells Regulate Their Capability to Present Antigen by Modulation of HLA-DO

Glazier, Kim S., Hake, Sandra B., Tobin, Helen M., Chadburn, Amy, Schattner, Elaine J., Denzin, Lisa K.

Peptide acquisition by MHC class II molecules is catalyzed by HLA-DM (DM). In B cells, HLA-DO (DO) inhibits or modifies the peptide exchange activity of DM. We show here that DO protein levels are...

HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules

Denzin, Lisa K., Hammond, Craig, Cresswell, Peter

Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM expression accumulate class II molecules associated with residual invariant (I) chain fragments (class...