Rubins, Kathleen H, Hensley, Lisa E, Wahl-Jensen, Victoria, Daddario DiCaprio, Kathleen M, Young, Howard A, Reed, Douglas S, ...
Abstract Background Infection with Ebola virus (EBOV) causes a fulminant and often fatal hemorrhagic fever. In order to improve our understanding of EBOV pathogenesis and EBOV-host interactions, we...
Effective Post-Exposure Treatment of Ebola Infection (2007)
Heinz Feldmann, Steven M. Jones, Joan B. Geisbert, Ute Ströher, Allen Grolla, ...
Ebola viruses are highly lethal human pathogens that have received considerable attention in recent years due to an increasing re-emergence in Central Africa and a potential for use as a biological...
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)
James V. Lawler, Timothy P. Endy, Lisa E. Hensley, Aura Garrison, Elizabeth A. Fritz, May Lesar, ...
Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)
James V. Lawler, Timothy P. Endy, Lisa E. Hensley, Aura Garrison, Elizabeth A. Fritz, May Lesar, ...
BackgroundThe emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the...
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome (2006)
Lawler, James V., Endy, Timothy P., Hensley, Lisa E., Garrison, Aura, Fritz, Elizabeth A., Lesar, May, ...
The emergence of severe acute respiratory syndrome (SARS) in 2002 - 2003 had a tremendous global impact. Adequate animal models are required to study the underlying pathogenesis of SARS-associated...
Development of a New Vaccine for the Prevention of Lassa Fever (2005)
Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Development of a New Vaccine for the Prevention of Lassa Fever (2005)
Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...
Background Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health...
Interferon-Beta 1a and SARS Coronavirus Replication (2004)
Hensley, Lisa E ., Fritz, Elizabeth A., Jahrling, Peter B., Karp, Christopher L., Huggins, John W.
A global outbreak of severe acute respiratory syndrome (SARS) caused by a novel coronavirus began in March 2003. The rapid emergence of SARS and the substantial illness and death it caused have made...
Jahrling, Peter B., Hensley, Lisa E., Martinez, Mark J., LeDuc, James W., Rubins, Kathleen H.
Smallpox virus (variola) poses a significant threat as an agent of bioterrorism. To mitigate this risk, antiviral drugs and an improved vaccine are urgently needed. Satisfactory demonstration of...
Ebola Virus: New Insights into Disease Aetiopathology and Possible Therapeutic Interventions (1998)
Geisbert, Thomas W., Hensley, Lisa E.
Ebola virus (EBOV) gained public notoriety in the last decade largely as a consequence of the highly publicised isolation of a new EBOV species in a suburb of Washington, DC, in 1989, together with...
Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques (1998)
Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S.
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...
Geisbert, Thomas W., Hensley, Lisa E., Jahrling, Peter B., Larsen, Tom, Geisbert, Joan B.
Infection with the Ebola virus induces overexpression of the procoagulant tissue factor in primate monocytes and macrophages, suggesting that inhibition of the tissue-factor pathway could ameliorate...
Jones, Steven M., Feldmann, Heinz, Stroher, Ute, Geisbert, Joan B., Fernando, Lisa, Grolla, Allen, ...
Vaccines and therapies are urgently needed to address public health needs stemming from emerging pathogens and biological threat agents such as the filoviruses Ebola virus (EBOV) and Marburg virus...
Daddario-DiCaprio, Kathleen M., Geisbert, Thomas W., Stroher, Ute, Geisbert, Joan B., Grolla, Allen, Fritz, Elizabeth A., ...
Effective countermeasures are urgently needed to prevent and treat infections caused by highly pathogenic and biological threat agents such as Marburg virus (MARV). We aimed to test the efficacy of a...
"... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology in the School of Public Health."
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
Yount, Boyd, Curtis, Kristopher M., Fritz, Elizabeth A., Hensley, Lisa E., Jahrling, Peter B., Prentice, Erik, ...
A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). Using a panel of contiguous cDNAs that span the entire genome, we have...
Rubins, Kathleen H., Hensley, Lisa E., Jahrling, Peter B., Whitney, Adeline R., Geisbert, Thomas W., Huggins, John W., ...
Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the...
Jahrling, Peter B., Hensley, Lisa E., Martinez, Mark J., LeDuc, James W., Rubins, Kathleen H., Relman, David A., ...
Smallpox virus (variola) poses a significant threat as an agent of bioterrorism. To mitigate this risk, antiviral drugs and an improved vaccine are urgently needed. Satisfactory demonstration of...
Development of a New Vaccine for the Prevention of Lassa Fever
Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome
Lawler, James V, Endy, Timothy P, Hensley, Lisa E, Garrison, Aura, Fritz, Elizabeth A, Lesar, May, ...
Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
Yount, Boyd, Curtis, Kristopher M., Fritz, Elizabeth A., Hensley, Lisa E., Jahrling, Peter B., Prentice, Erik, ...
A previously undescribed coronavirus (CoV) is the etiologic agent responsible for severe acute respiratory syndrome (SARS). Using a panel of contiguous cDNAs that span the entire genome, we have...
Rubins, Kathleen H., Hensley, Lisa E., Jahrling, Peter B., Whitney, Adeline R., Geisbert, Thomas W., Huggins, John W., ...
Smallpox has played an unparalleled role in human history and remains a significant potential threat to public health. Despite the historical significance of this disease, we know little about the...
Jahrling, Peter B., Hensley, Lisa E., Martinez, Mark J., LeDuc, James W., Rubins, Kathleen H., Relman, David A., ...
Smallpox virus (variola) poses a significant threat as an agent of bioterrorism. To mitigate this risk, antiviral drugs and an improved vaccine are urgently needed. Satisfactory demonstration of...
Development of a New Vaccine for the Prevention of Lassa Fever
Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome
Lawler, James V, Endy, Timothy P, Hensley, Lisa E, Garrison, Aura, Fritz, Elizabeth A, Lesar, May, ...
Jason Paragas and colleagues report the first findings of measurable clinical disease in nonhuman primates infected with the virus that causes SARS, SARS-CoV.
Effective Post-Exposure Treatment of Ebola Infection
Feldmann, Heinz, Jones, Steven M, Daddario-DiCaprio, Kathleen M, Geisbert, Joan B, Ströher, Ute, Grolla, Allen, ...
Ebola viruses are highly lethal human pathogens that have received considerable attention in recent years due to an increasing re-emergence in Central Africa and a potential for use as a biological...
Cross-Protection against Marburg Virus Strains by Using a Live, Attenuated Recombinant Vaccine
Daddario-DiCaprio, Kathleen M., Geisbert, Thomas W., Geisbert, Joan B., Ströher, Ute, Hensley, Lisa E., Grolla, Allen, ...
Marburg virus (MARV) has been associated with sporadic episodes of hemorrhagic fever, including a recent highly publicized outbreak in Angola that produced severe disease and significant mortality in...
Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S., Geisbert, Joan B., ...
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...
Geisbert, Thomas W., Young, Howard A., Jahrling, Peter B., Davis, Kelly J., Larsen, Tom, Kagan, Elliott, ...
Ebola virus (EBOV) infection causes a severe and often fatal hemorrhagic disease in humans and nonhuman primates. Whether infection of endothelial cells is central to the pathogenesis of EBOV...
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
Zhu, Zhongyu, Chakraborti, Samitabh, He, Yuxian, Roberts, Anjeanette, Sheahan, Tim, Xiao, Xiaodong, ...
The severe acute respiratory syndrome coronavirus (SARS-CoV) caused a worldwide epidemic in late 2002/early 2003 and a second outbreak in the winter of 2003/2004 by an independent animal-to-human...
Rubins, Kathleen H, Hensley, Lisa E, Wahl-Jensen, Victoria, Daddario DiCaprio, Kathleen M, Young, Howard A, Reed, Douglas S, ...
Primate blood cells were analysed for changes in global gene expression patterns at several time points following infection with Ebola virus, providing insights into potential mechanisms of viral...
Rubins, Kathleen H., Hensley, Lisa E., Bell, George W., Wang, Chunlin, Lefkowitz, Elliot J., Brown, Patrick O., ...
Geisbert, Thomas W., Daddario-DiCaprio, Kathleen M., Williams, Kinola J. N., Geisbert, Joan B., Leung, Anders, Feldmann, Friederike, ...
Recombinant vesicular stomatitis virus (VSV) vectors expressing homologous filoviral glycoproteins can completely protect rhesus monkeys against Marburg virus when administered after exposure and can...
Geisbert, Thomas W., Daddario-DiCaprio, Kathleen M., Lewis, Mark G., Geisbert, Joan B., Grolla, Allen, Leung, Anders, ...
Ebola virus (EBOV) is a significant human pathogen that presents a public health concern as an emerging/re-emerging virus and as a potential biological weapon. Substantial progress has been made over...