Kuznetsov, Sergey, Pellegrini, Manuela, Shuda, Kristy, Fernandez-Capetillo, Oscar, Liu, Yilun, Martin, Betty K., ...
RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA repair by homologous recombination. In mice, it is essential for viability. Therefore, we have...
Selective Removal of the Selenocysteine tRNA [Ser]Sec Gene (Trsp) in Mouse Mammary Epithelium (2003)
Kumaraswamy, Easwari, Carlson, Bradley A., Morgan, Fanta, Miyoshi, Keiko, Robinson, Gertraud W., Su, Dan, ...
Mice homozygous for an allele encoding the selenocysteine (Sec) tRNA [Ser]Sec gene (Trsp) flanked by loxP sites were generated. Cre recombinase-dependent removal of Trsp in these mice was lethal to...
Targeted Disruption of Ras-Grf2 Shows Its Dispensability for Mouse Growth and Development (2002)
Esteban, Luis Miguel, Núñez, Alejandro, Santos De Dios, Eugenio, Fernández-Medarde, Alberto, Porteros, Ángel, Tessarollo, Lino
The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system...
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development (2000)
Esteban, Luis Miguel, Fernández-Medarde, Alberto, López, Eva, Yienger, Kate, Ward, Jerrold M., Tessarollo, Lino, ...
The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in...
Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP
Taylor, Gregory A., Collazo, Carmen M., Yap, George S., Nguyen, Khuong, Gregorio, Theresa A., Taylor, Lynn S., ...
Interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of...
Liebl, Daniel J., Klesse, Laura J., Tessarollo, Lino, Wohlman, Todd, Parada, Luis F.
Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports...
Wong, Philip C., Waggoner, Darrel, Subramaniam, Jamuna R., Tessarollo, Lino, Bartnikas, Thomas B., Culotta, Valeria C., ...
Recent studies in Saccharomyces cerevisiae suggest that the delivery of copper to Cu/Zn superoxide dismutase (SOD1) is mediated by a cytosolic protein termed the copper chaperone for superoxide...
Maier, Donna L., Mani, Shyamala, Donovan, Stacy L., Soppet, Dan, Tessarollo, Lino, McCasland, James S., ...
There is strong evidence that growth-associated protein (GAP-43), a protein found only in the nervous system, regulates the response of neurons to axonal guidance signals. However, its role in...
Lyons, W. Ernest, Mamounas, Laura A., Ricaurte, George A., Coppola, Vincenzo, Reid, Susan W., Bora, Susan H., ...
Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons in the central nervous system. However, the role of endogenous BDNF in the development and function of...
Tessarollo, Lino, Tsoulfas, Pantelis, Donovan, Michael J., Palko, Mary Ellen, Blair-Flynn, Janet, Hempstead, Barbara L., ...
We have generated null mutant mice that lack expression of all isoforms encoded by the trkC locus. These mice display a behavioral phenotype characterized by a loss of proprioceptive neurons....
Sterneck, Esta, Paylor, Richard, Jackson-Lewis, Vernice, Libbey, Megan, Przedborski, Serge, Tessarollo, Lino, ...
CCAAT/enhancer binding protein δ (C/EBPδ) is a transcriptional regulator implicated in the hepatic acute phase response and in adipogenic and myeloid cell differentiation. We found that C/EBPδ is...
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development
Esteban, Luis M., Fernández-Medarde, Alberto, López, Eva, Yienger, Kate, Guerrero, Carmen, Ward, Jerrold M., ...
The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in...
Cse1l Is Essential for Early Embryonic Growth and Development
Bera, Tapan K., Bera, Jayati, Brinkmann, Ulrich, Tessarollo, Lino, Pastan, Ira
The CSE1L gene, the human homologue of the yeast chromosome segregation gene CSE1, is a nuclear transport factor that plays a role in proliferation as well as in apoptosis. CSE1 and CSE1L are...
Steingrímsson, Eiríkur, Tessarollo, Lino, Pathak, Bhavani, Hou, Ling, Arnheiter, Heinz, Copeland, Neal G., ...
The Mitf-Tfe family of basic helix–loop–helix-leucine zipper (bHLH-Zip) transcription factors encodes four family members: Mitf, Tfe3, Tfeb, and Tfec. In vitro, each protein in the family can...
Mistargeting hippocampal axons by expression of a truncated Eph receptor
Yue, Yong, Chen, Zhi-Yong, Gale, Nick W., Blair-Flynn, Jan, Hu, Tian-Jing, Yue, Xin, ...
Topographic mapping of axon terminals is a general principle of neural architecture that underlies the interconnections among many neural structures. The Eph family tyrosine kinase receptors and...
Targeted Disruption of Ras-Grf2 Shows Its Dispensability for Mouse Growth and Development
Fernández-Medarde, Alberto, Esteban, Luis M., Núñez, Alejandro, Porteros, Ángel, Tessarollo, Lino, Santos, Eugenio
The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system...
Selective Removal of the Selenocysteine tRNA[Ser]Sec Gene (Trsp) in Mouse Mammary Epithelium
Kumaraswamy, Easwari, Carlson, Bradley A., Morgan, Fanta, Miyoshi, Keiko, Robinson, Gertraud W., Su, Dan, ...
Mice homozygous for an allele encoding the selenocysteine (Sec) tRNA[Ser]Sec gene (Trsp) flanked by loxP sites were generated. Cre recombinase-dependent removal of Trsp in these mice was lethal to...
An essential role for C/EBPβ in female reproduction
Sterneck, Esta, Tessarollo, Lino, Johnson, Peter F.
A large number of intercellular signaling molecules have been identified that orchestrate female reproductive physiology. However, with the exception of steroid hormone receptors, little information...
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration
Akassoglou, Katerina, Malester, Brian, Xu, Jixiang, Tessarollo, Lino, Rosenbluth, Jack, Chao, Moses V.
Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by...
Chiang, Y. Jeffrey, Kim, Sahn-Ho, Tessarollo, Lino, Campisi, Judith, Hodes, Richard J.
TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that...
Chiang, Y. Jeffrey, Hemann, Michael T., Hathcock, Karen S., Tessarollo, Lino, Feigenbaum, Lionel, Hahn, William C., ...
Telomerase consists of two essential components, the telomerase RNA template (TR) and telomerase reverse transcriptase (TERT). The haplo-insufficiency of TR was recently shown to cause one form of...
Graveel, Carrie, Su, Yanli, Koeman, Julie, Wang, Ling-Mei, Tessarollo, Lino, Fiscella, Michele, ...
Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas as well as in other cancers. These mutations have been examined in several in vitro systems,...
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
Hisa, Tomoyuki, Spence, Sally E, Rachel, Rivka A, Fujita, Masami, Nakamura, Takuro, Ward, Jerrold M, ...
Meis1 and Hoxa9 expression is upregulated by retroviral integration in murine myeloid leukemias and in human leukemias carrying MLL translocations. Both genes also cooperate to induce leukemia in a...
Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice
Chiang, Y. Jeffrey, Nguyen, My-Linh, Gurunathan, Sujatha, Kaminker, Patrick, Tessarollo, Lino, Campisi, Judith, ...
Telomere length and function are crucial factors that determine the capacity for cell proliferation and survival, mediate cellular senescence, and play a role in malignant transformation in...
Garcia-Fresco, German P., Sousa, Aurea D., Pillai, Anilkumar M., Moy, Sheryl S., Crawley, Jacqueline N., Tessarollo, Lino, ...
Axo–glial junctions (AGJs) play a critical role in the organization and maintenance of molecular domains in myelinated axons. Neurexin IV/Caspr1/paranodin (NCP1) is an important player in the...
Liepinsh, Dmitry J., Grivennikov, Sergei I., Klarmann, Kimberly D., Lagarkova, Maria A., Drutskaya, Marina S., Lockett, Stephen J., ...
Lymphotoxin alpha (LTα) can exist in soluble form and exert tumor necrosis factor (TNF)-like activity through TNF receptors. Based on the phenotypes of knockout (KO) mice, the physiological...
The Scaffold Protein Cybr Is Required for Cytokine-Modulated Trafficking of Leukocytes In Vivo
Coppola, Vincenzo, Barrick, Colleen A., Bobisse, Sara, Rodriguez-Galan, Maria Cecilia, Pivetta, Michela, Reynolds, Della, ...
Trafficking and cell adhesion are key properties of cells of the immune system. However, the molecular pathways that control these cellular behaviors are still poorly understood. Cybr is a scaffold...
Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP
Taylor, Gregory A., Collazo, Carmen M., Yap, George S., Nguyen, Khuong, Gregorio, Theresa A., Taylor, Lynn S., ...
Interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of...
Liebl, Daniel J., Klesse, Laura J., Tessarollo, Lino, Wohlman, Todd, Parada, Luis F.
Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports...
Wong, Philip C., Waggoner, Darrel, Subramaniam, Jamuna R., Tessarollo, Lino, Bartnikas, Thomas B., Culotta, Valeria C., ...
Recent studies in Saccharomyces cerevisiae suggest that the delivery of copper to Cu/Zn superoxide dismutase (SOD1) is mediated by a cytosolic protein termed the copper chaperone for superoxide...
Maier, Donna L., Mani, Shyamala, Donovan, Stacy L., Soppet, Dan, Tessarollo, Lino, McCasland, James S., ...
There is strong evidence that growth-associated protein (GAP-43), a protein found only in the nervous system, regulates the response of neurons to axonal guidance signals. However, its role in...
Lyons, W. Ernest, Mamounas, Laura A., Ricaurte, George A., Coppola, Vincenzo, Reid, Susan W., Bora, Susan H., ...
Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons in the central nervous system. However, the role of endogenous BDNF in the development and function of...
Tessarollo, Lino, Tsoulfas, Pantelis, Donovan, Michael J., Palko, Mary Ellen, Blair-Flynn, Janet, Hempstead, Barbara L., ...
We have generated null mutant mice that lack expression of all isoforms encoded by the trkC locus. These mice display a behavioral phenotype characterized by a loss of proprioceptive neurons....
Sterneck, Esta, Paylor, Richard, Jackson-Lewis, Vernice, Libbey, Megan, Przedborski, Serge, Tessarollo, Lino, ...
CCAAT/enhancer binding protein δ (C/EBPδ) is a transcriptional regulator implicated in the hepatic acute phase response and in adipogenic and myeloid cell differentiation. We found that C/EBPδ is...
Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development
Esteban, Luis M., Fernández-Medarde, Alberto, López, Eva, Yienger, Kate, Guerrero, Carmen, Ward, Jerrold M., ...
The mammalian sos1 and sos2 genes encode highly homologous members of the Son-of-sevenless family of guanine nucleotide exchange factors. They are ubiquitously expressed and play key roles in...
Cse1l Is Essential for Early Embryonic Growth and Development
Bera, Tapan K., Bera, Jayati, Brinkmann, Ulrich, Tessarollo, Lino, Pastan, Ira
The CSE1L gene, the human homologue of the yeast chromosome segregation gene CSE1, is a nuclear transport factor that plays a role in proliferation as well as in apoptosis. CSE1 and CSE1L are...
Steingrímsson, Eiríkur, Tessarollo, Lino, Pathak, Bhavani, Hou, Ling, Arnheiter, Heinz, Copeland, Neal G., ...
The Mitf-Tfe family of basic helix–loop–helix-leucine zipper (bHLH-Zip) transcription factors encodes four family members: Mitf, Tfe3, Tfeb, and Tfec. In vitro, each protein in the family can...
Mistargeting hippocampal axons by expression of a truncated Eph receptor
Yue, Yong, Chen, Zhi-Yong, Gale, Nick W., Blair-Flynn, Jan, Hu, Tian-Jing, Yue, Xin, ...
Topographic mapping of axon terminals is a general principle of neural architecture that underlies the interconnections among many neural structures. The Eph family tyrosine kinase receptors and...
Targeted Disruption of Ras-Grf2 Shows Its Dispensability for Mouse Growth and Development
Fernández-Medarde, Alberto, Esteban, Luis M., Núñez, Alejandro, Porteros, Ángel, Tessarollo, Lino, Santos, Eugenio
The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system...
Selective Removal of the Selenocysteine tRNA[Ser]Sec Gene (Trsp) in Mouse Mammary Epithelium
Kumaraswamy, Easwari, Carlson, Bradley A., Morgan, Fanta, Miyoshi, Keiko, Robinson, Gertraud W., Su, Dan, ...
Mice homozygous for an allele encoding the selenocysteine (Sec) tRNA[Ser]Sec gene (Trsp) flanked by loxP sites were generated. Cre recombinase-dependent removal of Trsp in these mice was lethal to...
An essential role for C/EBPβ in female reproduction
Sterneck, Esta, Tessarollo, Lino, Johnson, Peter F.
A large number of intercellular signaling molecules have been identified that orchestrate female reproductive physiology. However, with the exception of steroid hormone receptors, little information...
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration
Akassoglou, Katerina, Malester, Brian, Xu, Jixiang, Tessarollo, Lino, Rosenbluth, Jack, Chao, Moses V.
Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by...
Chiang, Y. Jeffrey, Kim, Sahn-Ho, Tessarollo, Lino, Campisi, Judith, Hodes, Richard J.
TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism. Here we show that...
Chiang, Y. Jeffrey, Hemann, Michael T., Hathcock, Karen S., Tessarollo, Lino, Feigenbaum, Lionel, Hahn, William C., ...
Telomerase consists of two essential components, the telomerase RNA template (TR) and telomerase reverse transcriptase (TERT). The haplo-insufficiency of TR was recently shown to cause one form of...
Graveel, Carrie, Su, Yanli, Koeman, Julie, Wang, Ling-Mei, Tessarollo, Lino, Fiscella, Michele, ...
Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas as well as in other cancers. These mutations have been examined in several in vitro systems,...
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
Hisa, Tomoyuki, Spence, Sally E, Rachel, Rivka A, Fujita, Masami, Nakamura, Takuro, Ward, Jerrold M, ...
Meis1 and Hoxa9 expression is upregulated by retroviral integration in murine myeloid leukemias and in human leukemias carrying MLL translocations. Both genes also cooperate to induce leukemia in a...
Garcia-Fresco, German P., Sousa, Aurea D., Pillai, Anilkumar M., Moy, Sheryl S., Crawley, Jacqueline N., Tessarollo, Lino, ...
Axo–glial junctions (AGJs) play a critical role in the organization and maintenance of molecular domains in myelinated axons. Neurexin IV/Caspr1/paranodin (NCP1) is an important player in the...
Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice
Chiang, Y. Jeffrey, Nguyen, My-Linh, Gurunathan, Sujatha, Kaminker, Patrick, Tessarollo, Lino, Campisi, Judith, ...
Telomere length and function are crucial factors that determine the capacity for cell proliferation and survival, mediate cellular senescence, and play a role in malignant transformation in...
Liepinsh, Dmitry J., Grivennikov, Sergei I., Klarmann, Kimberly D., Lagarkova, Maria A., Drutskaya, Marina S., Lockett, Stephen J., ...
Lymphotoxin alpha (LTα) can exist in soluble form and exert tumor necrosis factor (TNF)-like activity through TNF receptors. Based on the phenotypes of knockout (KO) mice, the physiological...
The Scaffold Protein Cybr Is Required for Cytokine-Modulated Trafficking of Leukocytes In Vivo
Coppola, Vincenzo, Barrick, Colleen A., Bobisse, Sara, Rodriguez-Galan, Maria Cecilia, Pivetta, Michela, Reynolds, Della, ...
Trafficking and cell adhesion are key properties of cells of the immune system. However, the molecular pathways that control these cellular behaviors are still poorly understood. Cybr is a scaffold...
Ivanov, Sergey V., Ward, Jerrold M., Tessarollo, Lino, McAreavey, Dorothea, Sachdev, Vandana, Fananapazir, Lameh, ...
CACNA2D2 is a putative tumor suppressor gene located in the human chromosome 3p21.3 region that shows frequent allelic imbalances in lung, breast, and other cancers. The α2δ-2 protein encoded by...
Donovan, Michael J., Miranda, Rajesh C., Kraemer, Rosemary, McCaffrey, Timothy A., Tessarollo, Lino, Mahadeo, Debbie, ...
The neurotrophins, a family of related polypeptide growth factors including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-3 and NT-4/5 promote the survival...
Esteban, Pedro F., Yoon, Hye-Young, Becker, Jodi, Dorsey, Susan G., Caprari, Paola, Palko, Mary Ellen, ...
Neurotrophins play an essential role in mammalian development. Most of their functions have been attributed to activation of the kinase-active Trk receptors and the p75 neurotrophin receptor....
Kuznetsov, Sergey, Pellegrini, Manuela, Shuda, Kristy, Fernandez-Capetillo, Oscar, Liu, Yilun, Martin, Betty K., ...
RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA repair by homologous recombination. In mice, it is essential for viability. Therefore, we have...
Collazo, Carmen M., Yap, George S., Sempowski, Gregory D., Lusby, Kimberly C., Tessarollo, Lino, Woude, George F. Vande, ...
The cytokine interferon (IFN)-γ regulates immune clearance of parasitic, bacterial, and viral infections; however, the underlying mechanisms are poorly understood. Recently, a family of...
ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3
Bong, Yong-Sik, Lee, Hyun-Shik, Carim-Todd, Laura, Mood, Kathleen, Nishanian, Tagvor G., Tessarollo, Lino, ...
The Eph (erythropoietin-producing hepatoma) family of receptor tyrosine kinases and their membrane-bound ligands, the ephrins, have been implicated in regulating cell adhesion and migration during...