The p38α mitogen-activated protein kinase as a central nervous system drug discovery target (2008)
Borders, Aaron S, De Almeida, Lucia, Van Eldik, Linda J, Watterson, D Martin
Abstract Protein kinases are critical modulators of a variety of cellular signal transduction pathways, and abnormal phosphorylation events can be a cause or contributor to disease progression in a...
Thompson, Wendy L, Karpus, William J, Van Eldik, Linda J
Abstract Background An endotoxin insult mimics a severe peripheral infection and recent evidence suggests that a single exposure can cause long-term cognitive deficits. A peripheral injection of LPS...
Lloyd, Eric, Somera-Molina, Kathleen, Van Eldik, Linda J, Watterson, D Martin, Wainwright, Mark S
Abstract Background Traumatic brain injury (TBI) with its associated morbidity is a major area of unmet medical need that lacks effective therapies. TBI initiates a neuroinflammatory cascade...
Munoz, Lenka, Ranaivo, Hantamalala, Roy, Saktimayee M, Hu, Wenhui, Craft, Jeffrey M, McNamara, Laurie K, ...
Abstract Background An accumulating body of evidence is consistent with the hypothesis that excessive or prolonged increases in proinflammatory cytokine production by activated glia is a contributor...
Craft, Jeffrey M, Watterson, D Martin, Hirsch, Emmet, Van Eldik, Linda J
Abstract Background Interleukin 1 (IL-1) is a key mediator of immune responses in health and disease. Although classically the function of IL-1 has been studied in the systemic immune system,...
Petrova, Tatiana V., Akama, Keith T., Van Eldik, Linda J.
Mechanisms leading to down-regulation of activated microglia and astrocytes are poorly understood, in spite of the potentially detrimental role of activated glia in neurodegeneration. Prostaglandins,...
Akama, Keith T., Albanese, Chris, Pestell, Richard G., Van Eldik, Linda J.
The major pathological features of Alzheimer’s disease (AD) include amyloid plaques composed primarily of the β-amyloid (Aβ) peptide, degenerating neurons and neurofibrillary tangles, and the...
Wainwright, Mark S., Rossi, Janet, Schavocky, James, Crawford, Susan, Steinhorn, David, Velentza, Anastasia V., ...
Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule...
Clayburgh, Daniel R., Barrett, Terrence A., Tang, Yueming, Meddings, Jon B., Van Eldik, Linda J., Watterson, D. Martin, ...
Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined....
Petrova, Tatiana V., Akama, Keith T., Van Eldik, Linda J.
Mechanisms leading to down-regulation of activated microglia and astrocytes are poorly understood, in spite of the potentially detrimental role of activated glia in neurodegeneration. Prostaglandins,...
Akama, Keith T., Albanese, Chris, Pestell, Richard G., Van Eldik, Linda J.
The major pathological features of Alzheimer’s disease (AD) include amyloid plaques composed primarily of the β-amyloid (Aβ) peptide, degenerating neurons and neurofibrillary tangles, and the...
Wainwright, Mark S., Rossi, Janet, Schavocky, James, Crawford, Susan, Steinhorn, David, Velentza, Anastasia V., ...
Acute lung injury (ALI) associated with sepsis and iatrogenic ventilator-induced lung injury resulting from mechanical ventilation are major medical problems with an unmet need for small molecule...
Clayburgh, Daniel R., Barrett, Terrence A., Tang, Yueming, Meddings, Jon B., Van Eldik, Linda J., Watterson, D. Martin, ...
Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined....
Munoz, Lenka, Ranaivo, Hantamalala Ralay, Roy, Saktimayee M, Hu, Wenhui, Craft, Jeffrey M, McNamara, Laurie K, ...