Lin Leng

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress (2008)

Heng Ma, Jingying Wang, Erin Lane, Lin Leng, Wenkui Wang, Jun Ren, ...

An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been...

Null mutation for Macrophage Migration Inhibitory Factor (MIF) is associated with less aggressive bladder cancer in mice (2007)

Taylor, John A, Kuchel, George A, Hegde, Poornima, Voznesensky, Olga S, Claffey, Kevin, Tsimikas, John, ...

Abstract Background Inflammatory cytokines may promote tumorigenesis. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with regulatory properties over tumor suppressor...

Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies

Zhong, Xiao-bo, Leng, Lin, Beitin, Anna, Chen, Rui, McDonald, Courtney, Hsiao, Betty, ...

Microsatellite repeat and single nucleotide polymorphisms (SNPs) are abundant sources of genetic variation, but existing methodologies cannot simultaneously detect these variants in a facile or...

Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies

Zhong, Xiao-bo, Leng, Lin, Beitin, Anna, Chen, Rui, McDonald, Courtney, Hsiao, Betty, ...

Microsatellite repeat and single nucleotide polymorphisms (SNPs) are abundant sources of genetic variation, but existing methodologies cannot simultaneously detect these variants in a facile or...

Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion

Arjona, Alvaro, Foellmer, Harald G., Town, Terrence, Leng, Lin, McDonald, Courtney, Wang, Tian, ...

The flavivirus West Nile virus (WNV) is an emerging pathogen that causes life-threatening encephalitis in susceptible individuals. We investigated the role of the proinflammatory cytokine macrophage...

A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia

McDevitt, Michael A., Xie, Jianlin, Shanmugasundaram, Ganapathy, Griffith, Jason, Liu, Aihua, McDonald, Courtney, ...

The pathogenesis of malarial anemia is multifactorial, and the mechanisms responsible for its high mortality are poorly understood. Studies indicate that host mediators produced during malaria...

IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival

Binsky, Inbal, Haran, Michal, Starlets, Diana, Gore, Yael, Lantner, Frida, Harpaz, Nurit, ...

Chronic lymphocytic leukemia (CLL) is a malignant disease of small mature lymphocytes. Previous studies have shown that CLL B lymphocytes express relatively large amounts of CD74 mRNA relative to...

MIF Signal Transduction Initiated by Binding to CD74

Leng, Lin, Metz, Christine N., Fang, Yan, Xu, Jing, Donnelly, Seamas, Baugh, John, ...

Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has emerged recently to be an important regulator of innate and adaptive...