Autoregulation of the Human Liver X Receptor α Promoter
Laffitte, Bryan A., Joseph, Sean B., Walczak, Robert, Pei, Liming, Wilpitz, Damien C., Collins, Jon L., ...
Previous work has implicated the nuclear receptors liver X receptor α (LXRα) and LXRβ in the regulation of macrophage gene expression in response to oxidized lipids. Macrophage lipid loading leads...
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., ...
The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux...
Osteoporosis, characterized by low bone mass and structural deterioration of bone tissue with an increased susceptibility to fractures, is a major public health threat to the elderly. Bone mass...
Autoregulation of the Human Liver X Receptor α Promoter
Laffitte, Bryan A., Joseph, Sean B., Walczak, Robert, Pei, Liming, Wilpitz, Damien C., Collins, Jon L., ...
Previous work has implicated the nuclear receptors liver X receptor α (LXRα) and LXRβ in the regulation of macrophage gene expression in response to oxidized lipids. Macrophage lipid loading leads...
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Joseph, Sean B., McKilligin, Elaine, Pei, Liming, Watson, Michael A., Collins, Alan R., Laffitte, Bryan A., ...
The nuclear receptors LXRα and LXRβ have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux...
Osteoporosis, characterized by low bone mass and structural deterioration of bone tissue with an increased susceptibility to fractures, is a major public health threat to the elderly. Bone mass...
A role for IRF3-dependent RXRα repression in hepatotoxicity associated with viral infections
Chow, Edward K., Castrillo, Antonio, Shahangian, Arash, Pei, Liming, O'Connell, Ryan M., Modlin, Robert L., ...
Viral infections and antiviral responses have been linked to several metabolic diseases, including Reye's syndrome, which is aspirin-induced hepatotoxicity in the context of a viral infection. We...