PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice (2008)
Jichun Yang, Lihong Chen, Xiaoyan Zhang, Yunfeng Zhou, Dongjuan Zhang, Ming Huo, ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy...
TrED: the Trichophyton rubrumExpression Database (2007)
Yang, Jian, Chen, Lihong, Wang, Lingling, Zhang, Wenliang, Liu, Tao, Jin, Qi
Abstract Background Trichophyton rubrum is the most common dermatophyte species and the most frequent cause of fungal skin infections in humans worldwide. It's a major concern because feet and nail...
Liu, Tao, Zhang, Qian, Wang, Lingling, Yu, Lu, Leng, Wenchuan, Yang, Jian, ...
Abstract Background Conidia are considered to be the primary cause of infections by Trichophyton rubrum . Results We have developed a cDNA microarray containing 10250 ESTs to monitor the...
Complete genome sequence of Shigella flexneri5b and comparison with Shigella flexneri2a (2006)
Nie, Huan, Yang, Fan, Zhang, Xiaobing, Yang, Jian, Chen, Lihong, Wang, Jing, ...
Abstract Background Shigella bacteria cause dysentery, which remains a significant threat to public health. Shigella flexneri is the most common species in both developing and developed countries....
Yang, Baichun, Brown, Kathleen K, Chen, Lihong, Carrick, Kevin M, Clifton, Lisa G, McNulty, Judi A, ...
Abstract Background PPARγ agonists ameliorate insulin resistance and dyslipidemia in type 2 diabetic patients. Adiponectin possesses insulin sensitizing properties, and predicts insulin sensitivity...
Cloning and characterization of P-CIP1, a novel endosome-associated protein [microform] / (2000)
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2000.
Numerical and experimental modelling of brush seals--Lihong Chen. (1998)
Thesis (D.Phil.)--University of Oxford, 1998.
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
Chen, Lihong, Agrawal, Sudhir, Zhou, Wenqiang, Zhang, Ruiwen, Chen, Jiandong
The MDM2 oncogene encodes an inhibitor of the p53 tumor suppressor protein that regulates p53 in a negative feedback loop. MDM2 gene amplification and overexpression occur in several types of tumors...
MDM2 Suppresses p73 Function without Promoting p73 Degradation
Zeng, Xiaoya, Chen, Lihong, Jost, Christine A., Maya, Ruth, Keller, David, Wang, Xinjiang, ...
The newly identified p53 homolog p73 can mimic the transcriptional activation function of p53. We investigated whether p73, like p53, participates in an autoregulatory feedback loop with MDM2. p73...
DNA Damage Induces MDMX Nuclear Translocation by p53-Dependent and -Independent Mechanisms
Li, Changgong, Chen, Lihong, Chen, Jiandong
The MDM2 homolog MDMX is an important regulator of p53 activity during embryonic development. MDMX inactivation in mice results in embryonic lethality in a p53-dependent fashion. The expression level...
Norris, Andrew W., Chen, Lihong, Fisher, Simon J., Szanto, Ildiko, Ristow, Michael, Jozsi, Alison C., ...
Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It...
Yang, Baichun, Brown, Kathleen K, Chen, Lihong, Carrick, Kevin M, Clifton, Lisa G, McNulty, Judi A, ...
VFDB: a reference database for bacterial virulence factors
Chen, Lihong, Yang, Jian, Yu, Jun, Yao, Zhijian, Sun, Lilian, Shen, Yan, ...
Bacterial pathogens continue to impose a major threat to public health worldwide in the 21st century. Intensified studies on bacterial pathogenesis have greatly expanded our knowledge about the...
Regulation of p53-MDMX Interaction by Casein Kinase 1 Alpha
Chen, Lihong, Li, Changgong, Pan, Yu, Chen, Jiandong
MDMX is a homolog of MDM2 that is critical for regulating p53 function during mouse development. MDMX degradation is regulated by MDM2-mediated ubiquitination. Whether there are other mechanisms of...
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
Wang, Chuangui, Ivanov, Alexey, Chen, Lihong, Fredericks, William J, Seto, Ed, Rauscher, Frank J, ...
MDM2 is a RING domain ubiquitin E3 ligase and a major regulator of the p53 tumor suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 acetylation, and promotes p53...
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
Chen, Lihong, Gilkes, Daniele M, Pan, Yu, Lane, William S, Chen, Jiandong
The p53 tumor suppressor is activated after DNA damage to maintain genomic stability and prevent transformation. Rapid activation of p53 by ionizing radiation is dependent on signaling by the ATM...
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery
Yang, Fan, Yang, Jian, Zhang, Xiaobing, Chen, Lihong, Jiang, Yan, Yan, Yongliang, ...
The Shigella bacteria cause bacillary dysentery, which remains a significant threat to public health. The genus status and species classification appear no longer valid, as compelling evidence...
ShiBASE: an integrated database for comparative genomics of Shigella
Yang, Jian, Chen, Lihong, Yu, Jun, Sun, Lilian, Jin, Qi
Among the major enteric bacterial pathogens, Shigella is found to display extreme genome diversity and dynamics, which imposes a challenge in comparative genomic studies. To facilitate further...
Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a
Nie, Huan, Yang, Fan, Zhang, Xiaobing, Yang, Jian, Chen, Lihong, Wang, Jing, ...
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
Chen, Lihong, Agrawal, Sudhir, Zhou, Wenqiang, Zhang, Ruiwen, Chen, Jiandong
The MDM2 oncogene encodes an inhibitor of the p53 tumor suppressor protein that regulates p53 in a negative feedback loop. MDM2 gene amplification and overexpression occur in several types of tumors...
MDM2 Suppresses p73 Function without Promoting p73 Degradation
Zeng, Xiaoya, Chen, Lihong, Jost, Christine A., Maya, Ruth, Keller, David, Wang, Xinjiang, ...
The newly identified p53 homolog p73 can mimic the transcriptional activation function of p53. We investigated whether p73, like p53, participates in an autoregulatory feedback loop with MDM2. p73...
DNA Damage Induces MDMX Nuclear Translocation by p53-Dependent and -Independent Mechanisms
Li, Changgong, Chen, Lihong, Chen, Jiandong
The MDM2 homolog MDMX is an important regulator of p53 activity during embryonic development. MDMX inactivation in mice results in embryonic lethality in a p53-dependent fashion. The expression level...
Norris, Andrew W., Chen, Lihong, Fisher, Simon J., Szanto, Ildiko, Ristow, Michael, Jozsi, Alison C., ...
Activation of peroxisome proliferator-activated receptor γ (PPARγ) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It...
Yang, Baichun, Brown, Kathleen K, Chen, Lihong, Carrick, Kevin M, Clifton, Lisa G, McNulty, Judi A, ...
VFDB: a reference database for bacterial virulence factors
Chen, Lihong, Yang, Jian, Yu, Jun, Yao, Zhijian, Sun, Lilian, Shen, Yan, ...
Bacterial pathogens continue to impose a major threat to public health worldwide in the 21st century. Intensified studies on bacterial pathogenesis have greatly expanded our knowledge about the...
Regulation of p53-MDMX Interaction by Casein Kinase 1 Alpha
Chen, Lihong, Li, Changgong, Pan, Yu, Chen, Jiandong
MDMX is a homolog of MDM2 that is critical for regulating p53 function during mouse development. MDMX degradation is regulated by MDM2-mediated ubiquitination. Whether there are other mechanisms of...
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
Wang, Chuangui, Ivanov, Alexey, Chen, Lihong, Fredericks, William J, Seto, Ed, Rauscher, Frank J, ...
MDM2 is a RING domain ubiquitin E3 ligase and a major regulator of the p53 tumor suppressor. MDM2 binds to p53, inactivates p53 transcription function, inhibits p53 acetylation, and promotes p53...
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
Chen, Lihong, Gilkes, Daniele M, Pan, Yu, Lane, William S, Chen, Jiandong
The p53 tumor suppressor is activated after DNA damage to maintain genomic stability and prevent transformation. Rapid activation of p53 by ionizing radiation is dependent on signaling by the ATM...
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery
Yang, Fan, Yang, Jian, Zhang, Xiaobing, Chen, Lihong, Jiang, Yan, Yan, Yongliang, ...
The Shigella bacteria cause bacillary dysentery, which remains a significant threat to public health. The genus status and species classification appear no longer valid, as compelling evidence...
ShiBASE: an integrated database for comparative genomics of Shigella
Yang, Jian, Chen, Lihong, Yu, Jun, Sun, Lilian, Jin, Qi
Among the major enteric bacterial pathogens, Shigella is found to display extreme genome diversity and dynamics, which imposes a challenge in comparative genomic studies. To facilitate further...
Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a
Nie, Huan, Yang, Fan, Zhang, Xiaobing, Yang, Jian, Chen, Lihong, Wang, Jing, ...
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3
LeBron, Cynthia, Chen, Lihong, Gilkes, Daniele M, Chen, Jiandong
The MDM2 homolog MDMX is an important regulator of p53 during mouse embryonic development. DNA damage promotes MDMX phosphorylation, nuclear translocation, and degradation by MDM2. Here we show that...
Yu, Lu, Zhang, Wenliang, Wang, Lingling, Yang, Jian, Liu, Tao, Peng, Junping, ...
Trichophyton rubrum is a pathogenic filamentous fungus of increasing medical concern. Two antifungal agents, ketoconazole (KTC) and amphotericin B (AMB), have specific activity against dermatophytes....
TrED: the Trichophyton rubrum Expression Database
Yang, Jian, Chen, Lihong, Wang, Lingling, Zhang, Wenliang, Liu, Tao, Jin, Qi
Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting
Guan, Youfei, Zhang, Yahua, Wu, Jing, Qi, Zhonghua, Yang, Guangrui, Dou, Dou, ...
Clinical use of prostaglandin synthase–inhibiting NSAIDs is associated with the development of hypertension; however, the cardiovascular effects of antagonists for individual prostaglandin...
MDMX regulation of p53 response to ribosomal stress
Gilkes, Daniele M, Chen, Lihong, Chen, Jiandong
Ribosomal stress such as disruption of rRNA biogenesis activates p53 by release of ribosomal proteins from the nucleoli, which bind to MDM2 and inhibit p53 degradation. We found that p53 activation...
VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics
Yang, Jian, Chen, Lihong, Sun, Lilian, Yu, Jun, Jin, Qi
Virulence factor database (VFDB) was set up in 2004 dedicated for providing current knowledge of virulence factors (VFs) from various medical significant bacterial pathogens to facilitate...
PPARs and Female Reproduction: Evidence from Genetically Manipulated Mice
Yang, Jichun, Chen, Lihong, Zhang, Xiaoyan, Zhou, Yunfeng, Zhang, Dongjuan, Huo, Ming, ...
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors controlling many important physiological processes, including lipid and glucose metabolism, energy...