Lawrence S. Hon

The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression (2007)

Hon, Lawrence S, Zhang, Zemin

Abstract Background MicroRNAs (miRNAs) are small noncoding RNAs that bind mRNA target transcripts and repress gene expression. They have been implicated in multiple diseases, such as cancer, but the...

GeneHub-GEPIS: digital expression profiling for normal and cancer tissues based on an integrated gene database

Zhang, Yan, Luoh, Shiuh-Ming, Hon, Lawrence S., Baertsch, Robert, Wood, William I., Zhang, Zemin

GeneHub-GEPIS is a web application that performs digital expression analysis in human and mouse tissues based on an integrated gene database. Using aggregated expressed sequence tag (EST) library...

The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression

Hon, Lawrence S, Zhang, Zemin

A genome wide analysis of factors affecting repression of mRNAs by microRNAs reveals roles for 3'UTR length, the number of target sites on the mRNA and the distance between pairs of binding sites.