Minimizing the risk of reporting false positives in large-scale RNAi screens (2006)
Echeverri, Christophe J, Beachy, Philip A, Baum, Buzz, Boutros, Michael, Buchholz, Frank, Chanda, Sumit K, ...
Large-scale RNA interference (RNAi)-based analyses, very much as other 'omic' approaches, have inherent rates of false positives and negatives. The variability in the standards of care applied to...
Potential Role for ADAM15 in Pathological Neovascularization in Mice
Horiuchi, Keisuke, Weskamp, Gisela, Lum, Lawrence, Hammes, Hans-Peter, Cai, Hui, Brodie, Thomas A., ...
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of...
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
Zhang, Chi, Williams, Elizabeth H., Guo, Yurong, Lum, Lawrence, Beachy, Philip A.
The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in...
Potential Role for ADAM15 in Pathological Neovascularization in Mice
Horiuchi, Keisuke, Weskamp, Gisela, Lum, Lawrence, Hammes, Hans-Peter, Cai, Hui, Brodie, Thomas A., ...
ADAM15 (named for a disintegrin and metalloprotease 15, metargidin) is a membrane-anchored glycoprotein that has been implicated in cell-cell or cell-matrix interactions and in the proteolysis of...
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
Zhang, Chi, Williams, Elizabeth H., Guo, Yurong, Lum, Lawrence, Beachy, Philip A.
The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in...
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells
Dorner, Silke, Lum, Lawrence, Kim, Michelle, Paro, Renato, Beachy, Philip A., Green, Rachel
Posttranscriptional silencing by RNAi is initiated by dsRNAs that are processed into siRNAs that ultimately target homologous mRNAs for degradation. We used luciferase reporter constructs and a...