Pascal, Laura E, True, Lawrence D, Campbell, David S, Deutsch, Eric W, Risk, Michael, Coleman, Ilsa M, ...
Abstract Background: Expression levels of mRNA and protein by cell types exhibit a range of correlations for different genes. In this study, we compared levels of mRNA abundance for several cluster...
Pascal, Laura E, Deutsch, Eric W, Campbell, David S, Korb, Martin, True, Lawrence D, Liu, Alvin Y
Abstract Background Public databases are crucial for analysis of high-dimensional gene and protein expression data. The Urologic Epithelial Stem Cells (UESC) database http://scgap.systemsbiology.net/...
Molecular and cellular characterization of ABCG2 in the prostate (2007)
Pascal, Laura E, Oudes, Asa J, Petersen, Timothy W, Goo, Young, Walashek, Laura S, True, Lawrence D, ...
Abstract Background Identification and characterization of the prostate stem cell is important for understanding normal prostate development and carcinogenesis. The flow cytometry-based side...
Differential expression of CD10 in prostate cancer and its clinical implication (2007)
Dall'Era, Marc A, True, Lawrence D, Siegel, Andrew F, Porter, Michael P, Sherertz, Tracy M, Liu, Alvin Y
Abstract Background CD10 is a transmembrane metallo-endopeptidase that cleaves and inactivates a variety of peptide growth factors. Loss of CD10 expression is a common, early event in human prostate...
Transcriptomes of human prostate cells (2006)
Oudes, Asa J, Campbell, Dave S, Sorensen, Carrie M, Walashek, Laura S, True, Lawrence D, Liu, Alvin Y
Abstract Background The gene expression profiles of most human tissues have been studied by determining the transcriptome of whole tissue homogenates. Due to the solid composition of tissues it is...
Stromal mesenchyme cell genes of the human prostate and bladder (2005)
Goo, Young Ah, Goodlett, David R, Pascal, Laura E, Worthington, Kelsey D, Vessella, Robert L, True, Lawrence D, ...
Abstract Background Stromal mesenchyme cells play an important role in epithelial differentiation and likely in cancer as well. Induction of epithelial differentiation is organ-specific, and the...
Oudes, Asa J, Roach, Jared C, Walashek, Laura S, Eichner, Lillian J, True, Lawrence D, Vessella, Robert L, ...
Abstract Background Affymetrix GeneChip Array and Massively Parallel Signature Sequencing (MPSS) are two high throughput methodologies used to profile transcriptomes. Each method has certain...
Cell–cell interaction in prostate gene regulation and cytodifferentiation
Liu, Alvin Y., True, Lawrence D., LaTray, Leah, Nelson, Peter S., Ellis, William J., Vessella, Robert L., ...
To examine the role of intercellular interaction on cell differentiation and gene expression in human prostate, we separated the two major epithelial cell populations and studied them in isolation...
Oudes, Asa J, Roach, Jared C, Walashek, Laura S, Eichner, Lillian J, True, Lawrence D, Vessella, Robert L, ...
Stromal mesenchyme cell genes of the human prostate and bladder
Goo, Young Ah, Goodlett, David R, Pascal, Laura E, Worthington, Kelsey D, Vessella, Robert L, True, Lawrence D, ...
Transcriptomes of human prostate cells
Oudes, Asa J, Campbell, Dave S, Sorensen, Carrie M, Walashek, Laura S, True, Lawrence D, Liu, Alvin Y
Cell–cell interaction in prostate gene regulation and cytodifferentiation
Liu, Alvin Y., True, Lawrence D., LaTray, Leah, Nelson, Peter S., Ellis, William J., Vessella, Robert L., ...
To examine the role of intercellular interaction on cell differentiation and gene expression in human prostate, we separated the two major epithelial cell populations and studied them in isolation...
Oudes, Asa J, Roach, Jared C, Walashek, Laura S, Eichner, Lillian J, True, Lawrence D, Vessella, Robert L, ...
Stromal mesenchyme cell genes of the human prostate and bladder
Goo, Young Ah, Goodlett, David R, Pascal, Laura E, Worthington, Kelsey D, Vessella, Robert L, True, Lawrence D, ...
Transcriptomes of human prostate cells
Oudes, Asa J, Campbell, Dave S, Sorensen, Carrie M, Walashek, Laura S, True, Lawrence D, Liu, Alvin Y
Differential expression of CD10 in prostate cancer and its clinical implication
Dall'Era, Marc A, True, Lawrence D, Siegel, Andrew F, Porter, Michael P, Sherertz, Tracy M, Liu, Alvin Y
Heterogeneity in Primary and Metastatic Prostate Cancer as Defined by Cell Surface CD Profile
Liu, Alvin Y., Roudier, Martine P., True, Lawrence D.
Cluster designation (CD) antigens are cell surface markers that can be used to identify constituent cell populations of an organ. We have previously determined the CD phenotype of normal prostate...
Molecular and cellular characterization of ABCG2 in the prostate
Pascal, Laura E, Oudes, Asa J, Petersen, Timothy W, Goo, Young Ah, Walashek, Laura S, True, Lawrence D, ...
Human cancers express a mutator phenotype
Bielas, Jason H., Loeb, Keith R., Rubin, Brian P., True, Lawrence D., Loeb, Lawrence A.
Cancer cells contain numerous clonal mutations, i.e., mutations that are present in most or all malignant cells of a tumor and have presumably been selected because they confer a proliferative...
A Neuroendocrine/Small Cell Prostate Carcinoma Xenograft—LuCaP 49
True, Lawrence D., Buhler, Kent, Quinn, Janna, Williams, Emily, Nelson, Peter S., Clegg, Nigel, ...
The late stages of progression of prostate carcinoma are typically characterized by an androgen-insensitive, rapidly proliferative state. Some late-stage tumors are composed predominantly of...
Characterization of Prostate Cell Types by CD Cell Surface Molecules
Liu, Alvin Y., True, Lawrence D.
A set of monoclonal antibodies raised against lymphocyte cell surface molecules, the cluster designation (CD) antigens, was used to distinguish the constituent cell types of the prostate. The luminal...
Swanson, Kristin R., True, Lawrence D., Lin, Daniel W., Buhler, Kent R., Vessella, Robert, Murray, James D.
Prostate-specific antigen (PSA) is an enzyme produced by both normal and cancerous prostate epithelial cells. Although PSA is the most widely used serum marker to detect and follow patients with...
Quantum Dots for Molecular Pathology : Their Time Has Arrived
True, Lawrence D., Gao, Xiaohu
Assessing malignant tumors for expression of multiple biomarkers provides data that are critical for patient management. Quantum dot-conjugated probes to specific biomarkers are powerful tools that...
Pascal, Laura E, True, Lawrence D, Campbell, David S, Deutsch, Eric W, Risk, Michael, Coleman, Ilsa M, ...
Quality control in molecular immunohistochemistry
Immunoperoxidase histochemistry is a widespread method of assessing expression of biomolecules in tissue samples. Accurate assessment of the expression levels of genes is critical for the management...
A causal role for ERG in neoplastic transformation of prostate epithelium
Klezovitch, Olga, Risk, Michael, Coleman, Ilsa, Lucas, Jared M., Null, Manda, True, Lawrence D., ...
A significant proportion of human prostate cancers carry a chromosomal rearrangement resulting in the overexpression of the ETS transcription factor, ERG; however, the functional significance of this...