Posttranscriptional Regulation of Mammalian Methionine Synthase by B12 (1999)
Gulati, Sumedha, Brody, Lawrence C., Banerjee, Ruma V.
Methionine synthase is one of two key enzymes involved in the removal of the metabolite, homocysteine. Elevated homocysteine levels constitute a risk factor for cardiovascular diseases and for neural...
Russell, M.W., Du Manoir, S., Brody, Lawrence C., Collins, Francis S.
Peer Reviewed
Chromosomal localization of 15 ion channel genes (1996)
Russell, Mark W. W., Manoir, Stan, Munroe, David J., Collins, Francis S., Brody, Lawrence C.
Several human Mendelian diseases, including the long-QT syndrome, malignant hyperthermia, and episodic ataxia/myokymia syndrome, have recently been demonstrated to be due to mutations in ion channel...
Collins, Francis S., Boehnke, Michael, Chandrasekharappa, Settara C., Shearon, Tempie H., Ho, Peggy P., Couch, Fergus J., ...
The human homolog of the Saccharomyces cerevisiae cell division control 27 gene (CDC27) was mapped to human chromosome 17q12-q21 using a panel of human/rodent somatic cell hybrids and localized...
Transcript identification in the BRCA1 candidate region (1995)
Abel, Kenneth J., Couch, Fergus J., Merajver, Sofia D., Castilla, Lucio H., Brody, Lawrence C., Collins, Francis S., ...
Chromosome 17q12-21 is known to contain a gene (or genes) which confers susceptibility to early-onset breast cancer and ovarian cancer (BRCA1). Identification and isolation of BRCA1 will likely...
Couch, Fergus J., Abel, Kenneth J., Brody, Lawrence C., Boehnke, Michael, Collins, Francis S., Weber, Barbara L.
The gene encoding ATP-citrate lyase, designated ACLY, was mapped to human chromosome 17q12-q21 by PCR on a panel of human/rodent somatic cell hybrids and localized to 17q21.1 by PCH on a panel of...
Human BRCA1 inhibits growth in yeast: Potential use in diagnostic testing
Humphrey, Jeffrey S., Salim, Ali, Erdos, Michael R., Collins, Francis S., Brody, Lawrence C., Klausner, Richard D.
Germline-inactivating mutations of BRCA1 result in a hereditary predisposition to breast and ovarian cancer. Truncating mutations of BRCA1 predispose to cancer and can be ascertained by protein...
BRCA1 interacts with components of the histone deacetylase complex
Yarden, Ronit I., Brody, Lawrence C.
Germ-line mutations in the BRCA1 tumor-suppressor gene are associated with an increased susceptibility to breast and ovarian cancer. BRCA1 contains a carboxyl-terminal domain (BRCT) that is shared...
Targeted Disruption of the Methionine Synthase Gene in Mice
Swanson, Deborah A., Liu, Mei-Lan, Baker, Priscilla J., Garrett, Lisa, Stitzel, Michael, Wu, Jianmin, ...
Alterations in homocysteine, methionine, folate, and/or B12 homeostasis have been associated with neural tube defects, cardiovascular disease, and cancer. Methionine synthase, one of only two...
Tian, Huijun, Brody, Lawrence C., Landers, James P.
In this report, we explore the potential of capillary and microchip electrophoresis for heteroduplex analysis– (HDA) based mutation detection. Fluorescent dye-labeled primers (6-FAM-tagged) were...
A polymorphic synonymous mutation in human ornithine-δ-aminotransferase (N378N)
Martin, Laura S., Mitchell, Grant A., Michaud, Jacques, Brody, Lawrence C., Valle, David
Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study
Kirke, Peadar N, Mills, James L, Molloy, Anne M, Brody, Lawrence C, O'Leary, Valerie B, Daly, Leslie, ...
Human BRCA1 inhibits growth in yeast: Potential use in diagnostic testing
Humphrey, Jeffrey S., Salim, Ali, Erdos, Michael R., Collins, Francis S., Brody, Lawrence C., Klausner, Richard D.
Germline-inactivating mutations of BRCA1 result in a hereditary predisposition to breast and ovarian cancer. Truncating mutations of BRCA1 predispose to cancer and can be ascertained by protein...
BRCA1 interacts with components of the histone deacetylase complex
Yarden, Ronit I., Brody, Lawrence C.
Germ-line mutations in the BRCA1 tumor-suppressor gene are associated with an increased susceptibility to breast and ovarian cancer. BRCA1 contains a carboxyl-terminal domain (BRCT) that is shared...
Targeted Disruption of the Methionine Synthase Gene in Mice
Swanson, Deborah A., Liu, Mei-Lan, Baker, Priscilla J., Garrett, Lisa, Stitzel, Michael, Wu, Jianmin, ...
Alterations in homocysteine, methionine, folate, and/or B12 homeostasis have been associated with neural tube defects, cardiovascular disease, and cancer. Methionine synthase, one of only two...
Tian, Huijun, Brody, Lawrence C., Landers, James P.
In this report, we explore the potential of capillary and microchip electrophoresis for heteroduplex analysis– (HDA) based mutation detection. Fluorescent dye-labeled primers (6-FAM-tagged) were...
A polymorphic synonymous mutation in human ornithine-δ-aminotransferase (N378N)
Martin, Laura S., Mitchell, Grant A., Michaud, Jacques, Brody, Lawrence C., Valle, David
Brody, Lawrence C., Conley, Mary, Cox, Christopher, Kirke, Peadar N., McKeever, Mary P., Mills, James L., ...
Women who take folic acid periconceptionally reduce their risk of having a child with a neural tube defect (NTD) by >50%. A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C→T) is a...