The Inhibition of Polo Kinase by Matrimony Maintains G2 Arrest in the Meiotic Cell Cycle (2007)
Youbin Xiang, Satomi Takeo, Laurence Florens, Stacie E. Hughes, Li-Jun Huo, William D. Gilliland, ...
Many meiotic systems in female animals include a lengthy arrest in G2 that separates the end of pachytene from nuclear envelope breakdown (NEB). However, the mechanisms by which a meiotic cell can...
Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii (2006)
Ke Hu, Jeff Johnson, Laurence Florens, Martin Fraunholz, Sapna Suravajjala, Camille DiLullo, ...
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...
Proteomics Approach Reveals Novel Proteins on the Surface of Malaria-Infected Erythrocytes (2006)
Florens, Laurence, Liu, Xia, Wang, Yufeng, Yang, Shiguang, Schwartz, Owen, Peglar, Michael, ...
Proteins on the surface of parasite-infected erythrocytes (PIESPs) have been one of the major focuses of malaria research due to their role in pathogenesis and their potential as targets for immunity...
Global Analysis of Transcript and Protein Levels Across the Plasmodium falciparum Life Cycle (2006)
LeRoch, Karine G., Johnson, Jeffrey R., Florens, Laurence, Zhou, Yingyao, Santrosyan, Audrey, Grainger, Munira, ...
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein...
Proteome Analysis of Rhoptry-Enriched Fractions Isolated From Plasmodium Merozoites (2006)
Sam-Yellowe, Tobili Y., Florens, Laurence, Wang, Tongmin, Raine, J. D., Carucci, Daniel J., Sinden, Robert, ...
The rhoptries of Plasmodium species participate in merozoite invasion and modification of the host erythrocyte. However, only a few rhoptry proteins have been identified using conventional gene...
Johnson, Jeffrey R., Florens, Laurence, Carucci, Daniel J.
The recent completion of human, Anopheles gambiae, and Plasmodium falciparum genomes relevant to the study of human malaria allows the application of modern proteomic technologies to complement...
Sam-Yellowe, Tobili Y., Florens, Laurence, Johnson, Jeffrey R., Wang, Tongmin, Drazba, Judith A., Le Roch, Karine G., ...
Upon invasion of the erythrocyte cell, the malaria parasite remodels its environment; in particular, it establishes a complex membrane network, which connects the parasitophorous vacuole to the host...
Holly E. Trueman, J. Dale Raine, Laurence Florens, Johannes T. Dessens, Jacqui Mendoza, Jeffrey Johnson, ...
Using bioinformatic, proteomic, immunofluorescence, and genetic cross methods, we have functionally characterized a family of putative parasite ligands as potential mediators of cell–cell...
Tomomori-Sato, Chieri, Sato, Shigeo, Parmely, Tari J., Banks, Charles A. S., Sorokina, Irina, Florens, Laurence, ...
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. We previously identified and partially purified a...
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
Doolan, Denise L., Southwood, Scott, Freilich, Daniel A., Sidney, John, Graber, Norma L., Shatney, Lori, ...
The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for vaccine development. Here we present, in...
Sam-Yellowe, Tobili Y., Florens, Laurence, Johnson, Jeffrey R., Wang, Tongmin, Drazba, Judith A., Le Roch, Karine G., ...
Upon invasion of the erythrocyte cell, the malaria parasite remodels its environment; in particular, it establishes a complex membrane network, which connects the parasitophorous vacuole to the host...
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Le Roch, Karine G., Johnson, Jeffrey R., Florens, Laurence, Zhou, Yingyao, Santrosyan, Andrey, Grainger, Munira, ...
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein...
Lee, Kenneth K., Florens, Laurence, Swanson, Selene K., Washburn, Michael P., Workman, Jerry L.
Covalent modifications of the histone tails and the cross talk between these modifications are hallmark features of gene regulation. The SAGA histone acetyltransferase complex is one of the most...
Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
Hu, Ke, Johnson, Jeff, Florens, Laurence, Fraunholz, Martin, Suravajjala, Sapna, DiLullo, Camille, ...
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...
Guelman, Sebastián, Suganuma, Tamaki, Florens, Laurence, Swanson, Selene K., Kiesecker, Cheri L., Kusch, Thomas, ...
Gcn5 is a conserved histone acetyltransferase (HAT) found in a number of multisubunit complexes from Saccharomyces cerevisiae, mammals, and flies. We previously identified Drosophila melanogaster...
Mnd1/Hop2 Facilitates Dmc1-Dependent Interhomolog Crossover Formation in Meiosis of Budding Yeast†
Henry, Jill M., Camahort, Raymond, Rice, Douglas A., Florens, Laurence, Swanson, Selene K., Washburn, Michael P., ...
During meiosis, each chromosome must pair with its homolog and undergo meiotic crossover recombination in order to segregate properly at the first meiotic division. Recombination in meiosis in...
Prochasson, Philippe, Florens, Laurence, Swanson, Selene K., Washburn, Michael P., Workman, Jerry L.
The histone regulatory (HIR) and histone promoter control (HPC) repressor proteins regulate three of the four histone gene loci during the Saccharomyces cerevisiae cell cycle. Here, we demonstrate...
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
Doolan, Denise L., Southwood, Scott, Freilich, Daniel A., Sidney, John, Graber, Norma L., Shatney, Lori, ...
The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for vaccine development. Here we present, in...
Sam-Yellowe, Tobili Y., Florens, Laurence, Johnson, Jeffrey R., Wang, Tongmin, Drazba, Judith A., Le Roch, Karine G., ...
Upon invasion of the erythrocyte cell, the malaria parasite remodels its environment; in particular, it establishes a complex membrane network, which connects the parasitophorous vacuole to the host...
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Le Roch, Karine G., Johnson, Jeffrey R., Florens, Laurence, Zhou, Yingyao, Santrosyan, Andrey, Grainger, Munira, ...
To investigate the role of post-transcriptional controls in the regulation of protein expression for the malaria parasite, Plasmodium falciparum, we have compared mRNA transcript and protein...
Lee, Kenneth K., Florens, Laurence, Swanson, Selene K., Washburn, Michael P., Workman, Jerry L.
Covalent modifications of the histone tails and the cross talk between these modifications are hallmark features of gene regulation. The SAGA histone acetyltransferase complex is one of the most...
Prochasson, Philippe, Florens, Laurence, Swanson, Selene K., Washburn, Michael P., Workman, Jerry L.
The histone regulatory (HIR) and histone promoter control (HPC) repressor proteins regulate three of the four histone gene loci during the Saccharomyces cerevisiae cell cycle. Here, we demonstrate...
Guelman, Sebastián, Suganuma, Tamaki, Florens, Laurence, Swanson, Selene K., Kiesecker, Cheri L., Kusch, Thomas, ...
Gcn5 is a conserved histone acetyltransferase (HAT) found in a number of multisubunit complexes from Saccharomyces cerevisiae, mammals, and flies. We previously identified Drosophila melanogaster...
Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
Hu, Ke, Johnson, Jeff, Florens, Laurence, Fraunholz, Martin, Suravajjala, Sapna, DiLullo, Camille, ...
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...
Mnd1/Hop2 Facilitates Dmc1-Dependent Interhomolog Crossover Formation in Meiosis of Budding Yeast†
Henry, Jill M., Camahort, Raymond, Rice, Douglas A., Florens, Laurence, Swanson, Selene K., Washburn, Michael P., ...
During meiosis, each chromosome must pair with its homolog and undergo meiotic crossover recombination in order to segregate properly at the first meiotic division. Recombination in meiosis in...
Guelman, Sebastián, Suganuma, Tamaki, Florens, Laurence, Weake, Vikki, Swanson, Selene K., Washburn, Michael P., ...
Histone acetylation provides a switch between transcriptionally repressive and permissive chromatin. By regulating the chromatin structure at specific promoters, histone acetyltransferases (HATs)...
Ctk Complex-Mediated Regulation of Histone Methylation by COMPASS▿
Wood, Adam, Shukla, Abhijit, Schneider, Jessica, Lee, Jung Shin, Stanton, Julie D., Dzuiba, Tiffany, ...
A comparative global proteomic screen identified factors required for COMPASS (complex of proteins associated with Set1)-mediated mono-, di-, and trimethylation of the fourth lysine of histone H3...
Paoletti, Andrew C., Parmely, Tari J., Tomomori-Sato, Chieri, Sato, Shigeo, Zhu, Dongxiao, Conaway, Ronald C., ...
Components of multiprotein complexes are routinely determined by using proteomic approaches. However, this information lacks functional content except when new complex members are identified. To...
Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle
Hrecka, Kasia, Gierszewska, Magdalena, Srivastava, Smita, Kozaczkiewicz, Lukasz, Swanson, Selene K., Florens, Laurence, ...
The replication of viruses depends on the cell cycle status of the infected cells. Viruses have evolved functions that alleviate restrictions imposed on their replication by the host. Vpr, an...
The Inhibition of Polo Kinase by Matrimony Maintains G2 Arrest in the Meiotic Cell Cycle
Xiang, Youbin, Takeo, Satomi, Florens, Laurence, Hughes, Stacie E, Huo, Li-Jun, Gilliland, William D, ...
Many meiotic systems in female animals include a lengthy arrest in G2 that separates the end of pachytene from nuclear envelope breakdown (NEB). However, the mechanisms by which a meiotic cell can...
CHD8 Associates with Human Staf and Contributes to Efficient U6 RNA Polymerase III Transcription▿
Yuan, Chih-Chi, Zhao, Xinyang, Florens, Laurence, Swanson, Selene K., Washburn, Michael P., Hernandez, Nouria
Chromatin remodeling and histone modification are essential for eukaryotic transcription regulation, but little is known about chromatin-modifying activities acting on RNA polymerase III (Pol...
Srivastava, Smita, Swanson, Selene K., Manel, Nicolas, Florens, Laurence, Washburn, Michael P., Skowronski, Jacek
Vpx is a small virion-associated adaptor protein encoded by viruses of the HIV-2/SIVsm lineage of primate lentiviruses that enables these viruses to transduce monocyte-derived cells. This probably...
Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics
Sardiu, Mihaela E., Cai, Yong, Jin, Jingji, Swanson, Selene K., Conaway, Ronald C., Conaway, Joan W., ...
Large-scale affinity purification and mass spectrometry studies have played important roles in the assembly and analysis of comprehensive protein interaction networks for lower eukaryotes. However,...
Fan, Xiaoxue, Martin-Brown, Skylar, Florens, Laurence, Li, Rong
The ability of actin filaments to function in cell morphogenesis and motility is closely coupled to their dynamic properties. Yeast cells contain two prominent actin structures, cables and patches,...