A functional network involved in the recycling of nucleocytoplasmic pre-60S factors
Lebreton, Alice, Saveanu, Cosmin, Decourty, Laurence, Rain, Jean-Christophe, Jacquier, Alain, Fromont-Racine, Micheline
Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the...
Hmo1 Is Required for TOR-Dependent Regulation of Ribosomal Protein Gene Transcription▿ †
Berger, Axel B., Decourty, Laurence, Badis, Gwenaël, Nehrbass, Ulf, Jacquier, Alain, Gadal, Olivier
Ribosome biogenesis requires equimolar amounts of four rRNAs and all 79 ribosomal proteins (RP). Coordinated regulation of rRNA and RP synthesis by eukaryotic RNA polymerases (Pol) I, III, and II is...
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins
Fromont-Racine, Micheline, Mayes, Andrew E., Brunet-Simon, Adeline, Rain, Jean-Christophe, Colley, Alan, Dix, Ian, ...
A set of seven structurally related Sm proteins forms the core of the snRNP particles containing the spliceosomal U1, U2, U4 and U5 snRNAs. A search of the genomic sequence of Saccharomyces...
Decourty, Laurence, Saveanu, Cosmin, Zemam, Kenza, Hantraye, Florence, Frachon, Emmanuel, Rousselle, Jean-Claude, ...
Describing at a genomic scale how mutations in different genes influence one another is essential to the understanding of how genotype correlates with phenotype and remains a major challenge in...