Just-in-time assembly of cell-cycle protein complexes (2008)
Lars J. Jensen, Ulrik De Lichtenberg, Thomas S. Jensen, Søren Brunak, Peer Bork
Our comparative analysis of eukaryotic cell-cycle complexes reveals that the identity of the periodically expressed subunits differs significantly between organisms and is often mirrored by changes...
STRING and STITCH: known and predicted interactions between proteins and chemicals (2008)
Lars J. Jensen, Michael Kuhn, Manuel Stark, Samuel Chaffron, Christian Von Mering, Peer Bork
Information on protein-protein and protein-chemical interactions is essential for understanding cellular functions. The STRING and STITCH web resources integrate interaction evidence derived from...
The What, Why and How of openness in science (2008)
Konrad U. Foerstner, Lars J. Jensen
We give a short introduction to open science followed by an overview of Creative Commons and open source licenses.
Hooper, Sean D., Boué, Stephanie, Krause, Roland, Jensen, Lars J., Mason, Christopher E., Ghanim, Murad, ...
Hooper, Sean D ., Boué, Stephanie, Krause, Roland, Jensen, Lars J ., Mason, Christopher E., Ghanim, Murad, ...
Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By...
Fabiana Perocchi, Lars J. Jensen, Julien Gagneur, Uwe Ahting, Christian Von Mering, Peer Bork, ...
Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified,...
Extraction of Transcript Diversity from Scientific Literature (2005)
Parantu K Shah, Lars J Jensen, Stéphanie Boué, Peer Bork
Transcript diversity generated by alternative splicing and associated mechanisms contributes heavily to the functional complexity of biological systems. The numerous examples of the mechanisms and...
Systematic Association of Genes to Phenotypes by Genome and Literature Mining (2005)
Jan O. Korbel, Tobias Doerks, Lars J. Jensen, Carolina Perez-Iratxeta, Szymon Kaczanowski, Sean D. Hooper, ...
The combination of text mining and comparative genomics is shown to be a powerful approach to predicting phenotypes that are associated with particular genes in bacterial genomes.
Systematic Association of Genes to Phenotypes by Genome and Literature Mining (2005)
Jan O. Korbel, Tobias Doerks, Lars J. Jensen, Carolina Perez-Iratxeta, Szymon Kaczanowski, Sean D. Hooper, ...
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of...
Manuel J. Gmez, Francisco Javier Guijarro, Ramn P. Otero, Lars J. Jensen, Sren Brunak, Alfonso Valencia
Introduction Protein function prediction is a key aspect of genome annotation that mainly relies on detecting near or remote homology, by sequence similarity. When no clear homologs can be detected,...
Analysis of Two Large Functionally Uncharacterized Regions in the . . . (2003)
Lars J. Jensen, Marie Skovgaard, Merete K. Jorgensen, Christiane Lundegaard, Corinna C. Pedersen, Nanna Petersen
this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL
Structural analysis of DNA sequence: evidence for lateral gene transfer in Thermotoga maritima
Worning, Peder, Jensen, Lars J., Nelson, Karen E., Brunak, Søren, Ussery, David W.
The recently published complete DNA sequence of the bacterium Thermotoga maritima provides evidence, based on protein sequence conservation, for lateral gene transfer between Archaea and Bacteria. We...
Von Mering, Christian, Jensen, Lars J., Snel, Berend, Hooper, Sean D., Krupp, Markus, Foglierini, Mathilde, ...
A full description of a protein's function requires knowledge of all partner proteins with which it specifically associates. From a functional perspective, ‘association’ can mean direct physical...
Systematic Association of Genes to Phenotypes by Genome and Literature Mining
Korbel, Jan O, Doerks, Tobias, Jensen, Lars J, Perez-Iratxeta, Carolina, Kaczanowski, Szymon, Hooper, Sean D, ...
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of...
Extraction of Transcript Diversity from Scientific Literature
Shah, Parantu K, Jensen, Lars J, Boué, Stéphanie, Bork, Peer
Transcript diversity generated by alternative splicing and associated mechanisms contributes heavily to the functional complexity of biological systems. The numerous examples of the mechanisms and...
Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle
Perocchi, Fabiana, Jensen, Lars J, Gagneur, Julien, Ahting, Uwe, Von Mering, Christian, Bork, Peer, ...
Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified,...
Structural analysis of DNA sequence: evidence for lateral gene transfer in Thermotoga maritima
Worning, Peder, Jensen, Lars J., Nelson, Karen E., Brunak, Søren, Ussery, David W.
The recently published complete DNA sequence of the bacterium Thermotoga maritima provides evidence, based on protein sequence conservation, for lateral gene transfer between Archaea and Bacteria. We...
Von Mering, Christian, Jensen, Lars J., Snel, Berend, Hooper, Sean D., Krupp, Markus, Foglierini, Mathilde, ...
A full description of a protein's function requires knowledge of all partner proteins with which it specifically associates. From a functional perspective, ‘association’ can mean direct physical...
Systematic Association of Genes to Phenotypes by Genome and Literature Mining
Korbel, Jan O, Doerks, Tobias, Jensen, Lars J, Perez-Iratxeta, Carolina, Kaczanowski, Szymon, Hooper, Sean D, ...
One of the major challenges of functional genomics is to unravel the connection between genotype and phenotype. So far no global analysis has attempted to explore those connections in the light of...
Extraction of Transcript Diversity from Scientific Literature
Shah, Parantu K, Jensen, Lars J, Boué, Stéphanie, Bork, Peer
Transcript diversity generated by alternative splicing and associated mechanisms contributes heavily to the functional complexity of biological systems. The numerous examples of the mechanisms and...
Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle
Perocchi, Fabiana, Jensen, Lars J, Gagneur, Julien, Ahting, Uwe, Von Mering, Christian, Bork, Peer, ...
Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified,...
STRING 7—recent developments in the integration and prediction of protein interactions
Von Mering, Christian, Jensen, Lars J., Kuhn, Michael, Chaffron, Samuel, Doerks, Tobias, Krüger, Beate, ...
Information on protein–protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The...
Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis
Hooper, Sean D, Boué, Stephanie, Krause, Roland, Jensen, Lars J, Mason, Christopher E, Ghanim, Murad, ...
Time-series analysis of whole-genome expression data during Drosophila melanogaster development indicates that up to 86% of its genes change their relative transcript level during embryogenesis. By...
Jensen, Lars J, Salomonsson, Max, Jensen, Boye L, Holstein-Rathlou, Niels-Henrik
In this study, intracellular Ca2+ was measured as the Fura-2 ratio (R) of fluorescence excited at 340 and 380 nm (F340/F380) in nonpressurized rat mesenteric small arterioles (Ø (lumen diameter)...
Jensen, Lars J., Sørensen, Jens N., Larsen, E. Hviid, Willumsen, Niels J.
We have hypothesized that a major role of the apical H+-pump in mitochondria-rich (MR) cells of amphibian skin is to energize active uptake of Cl− via an apical Cl−/HCO3−-exchanger. The...