Lanlan Shen, Yutaka Kondo, Yi Guo, Jiexin Zhang, Li Zhang, Saira Ahmed, ...
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter...
Lanlan Shen, Yutaka Kondo, Yi Guo, Jiexin Zhang, Li Zhang, Saira Ahmed, ...
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter...
Correlation between CpG methylation profiles and hormone receptor status in breast cancers (2007)
Feng, Weiwei, Shen, Lanlan, Wen, Sijin, Rosen, Daniel G, Jelinek, Jaroslav, Hu, Xin, ...
Abstract Introduction Aberrant DNA methylation has been found frequently in human breast cancers, associated with the loss of expression of a number of regulatory genes for growth and correlated to...
HLTF gene silencing in human colon cancer. (2002)
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer
Kondo, Yutaka, Shen, LanLan, Issa, Jean-Pierre J.
The mechanism of DNA hypermethylation-associated tumor suppressor gene silencing in cancer remains incompletely understood. Here, we show by chromatin immunoprecipitation that for three genes (P16,...
Kondo, Yutaka, Shen, Lanlan, Yan, Pearlly S., Huang, Tim Hui-Ming, Issa, Jean-Pierre J.
Switching from acetylation to methylation at histone H3 lysine 9 (K9) has recently been shown to contribute to euchromatin gene silencing. To identify genes silenced by K9 modifications, we probed a...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer
Kondo, Yutaka, Shen, LanLan, Issa, Jean-Pierre J.
The mechanism of DNA hypermethylation-associated tumor suppressor gene silencing in cancer remains incompletely understood. Here, we show by chromatin immunoprecipitation that for three genes (P16,...
Kondo, Yutaka, Shen, Lanlan, Yan, Pearlly S., Huang, Tim Hui-Ming, Issa, Jean-Pierre J.
Switching from acetylation to methylation at histone H3 lysine 9 (K9) has recently been shown to contribute to euchromatin gene silencing. To identify genes silenced by K9 modifications, we probed a...
Estécio, Marcos R.H., Gharibyan, Vazganush, Shen, Lanlan, Ibrahim, Ashraf E.K., Doshi, Ketan, He, Rong, ...
CpG Island Methylation in Colorectal Adenomas
Rashid, Asif, Shen, Lanlan, Morris, Jeffrey S., Issa, Jean-Pierre J., Hamilton, Stanley R.
Methylation of cytosines in CpG islands silences gene expression. CpG island methylator phenotype (CIMP) in colorectal cancers is characterized by abnormal methylation of multiple CpG islands...
Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters
Shen, Lanlan, Kondo, Yutaka, Guo, Yi, Zhang, Jiexin, Zhang, Li, Ahmed, Saira, ...
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter...
Correlation between CpG methylation profiles and hormone receptor status in breast cancers
Feng, Weiwei, Shen, Lanlan, Wen, Sijin, Rosen, Daniel G, Jelinek, Jaroslav, Hu, Xin, ...
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia
Lee, Sangkyou, Jeong, Joon, Majewski, Tadeusz, Scherer, Steven E., Kim, Mi-Sook, Tuziak, Tomasz, ...
We used human bladder cancer as a model system and the whole-organ histologic and genetic mapping strategy to identify clonal genetic hits associated with growth advantage, tracking the evolution of...
High-throughput methylation profiling by MCA coupled to CpG island microarray
Estécio, Marcos R.H., Yan, Pearlly S., Ibrahim, Ashraf E.K., Tellez, Carmen S., Shen, Lanlan, Huang, Tim H.-M., ...
An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms. The lack of high-throughput methods with high specificity and sensitivity to detect changes in DNA methylation...
Kondo, Yutaka, Shen, Lanlan, Ahmed, Saira, Boumber, Yanis, Sekido, Yoshitaka, Haddad, Bassem R., ...
Chung, Woonbok, Kwabi-Addo, Bernard, Ittmann, Michael, Jelinek, Jaroslav, Shen, Lanlan, Yu, Yinhua, ...
DNA hypermethylation is a common epigenetic abnormality in cancer and may serve as a useful marker to clone cancer-related genes as well as a marker of clinical disease activity. To identify CpG...
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
Shen, Lanlan, Toyota, Minoru, Kondo, Yutaka, Lin, E, Zhang, Li, Guo, Yi, ...
Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. However, this view does not fully reflect the molecular heterogeneity of the disease....
An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection
Boumber, Yanis A., Kondo, Yutaka, Chen, Xuqi, Shen, Lanlan, Guo, Yi, Tellez, Carmen, ...
Hundreds of genes show aberrant DNA hypermethylation in cancer, yet little is known about the causes of this hypermethylation. We identified RIL as a frequent methylation target in cancer. In search...