Anup Kumar Biswas, Abdul Hafiz, Bhaswati Banerjee, Kwang Sik Kim, Kasturi Datta, Chetan E. Chitnis
The ability of Plasmodium falciparum–infected red blood cells (IRBCs) to bind to vascular endothelium, thus enabling sequestration in vital host organs, is an important pathogenic mechanism in...
Sissons, James, Kim, Kwang Sik, Stins, Monique, Jayasekera, Samantha, Alsam, Selwa, Khan, Naveed Ahmed
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain...
Teng, Ching-Hao, Cai, Mian, Shin, Sooan, Xie, Yi, Kim, Kee-Jun, Khan, Naveed Ahmed, ...
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E....
Sissons, James, Kim, Kwang Sik, Stins, Monique, Jayasekera, Samantha, Alsam, Selwa, Khan, Naveed Ahmed
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain...
Teng, Ching-Hao, Cai, Mian, Shin, Sooan, Xie, Yi, Kim, Kee-Jun, Khan, Naveed Ahmed, ...
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E....
Sissons, James, Kim, Kwang Sik, Stins, Monique, Jayasekera, Samantha, Alsam, Selwa, Khan, Naveed Ahmed
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain...
Teng, Ching-Hao, Cai, Mian, Shin, Sooan, Xie, Yi, Kim, Kee-Jun, Khan, Naveed Ahmed, ...
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E....
Sissons, James, Kim, Kwang Sik, Stins, Monique, Jayasekera, Samantha, Alsam, Selwa, Khan, Naveed Ahmed
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain...
Teng, Ching-Hao, Cai, Mian, Shin, Sooan, Xie, Yi, Kim, Kee-Jun, Khan, Naveed Ahmed, ...
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E....
AFRICAN TRYPANOSOME INTERACTIONS WITH AN IN VITRO MODEL OF THE HUMAN BLOOD–BRAIN BARRIER (2004)
Dennis J. Grab, Olga Nikolskaia, Yuri V. Kim, Susumu Ito, Tatsuru Hara, ...
The neurological manifestations of sleeping sickness in man are attributed to the penetration of the blood–brain barrier (BBB) and invasion of the central nervous system by Trypanosoma brucei...
Vita.
Prasadarao, Nemani V., Wass, Carol A., Huang, Sheng-He, Kim, Kwang Sik
The molecular basis of Escherichia coli traversal of the blood-brain barrier in the development of E. coli meningitis is not well understood. We have previously shown that a novel Ibe10 protein found...
Prasadarao, Nemani V., Lysenko, Elena, Wass, Carol A., Kim, Kwang Sik, Weiser, Jeffrey N.
Opacity-associated protein A (OapA), which is responsible for the transparent-colony phenotype of Haemophilus influenzae, has been implicated in the colonization of the nasopharynx in an infant rat...
Wang, Ying, Huang, Sheng-He, Wass, Carol A., Stins, Monique F., Kim, Kwang Sik
Most cases of Escherichia coli meningitis develop as a result of hematogenous spread, but it is not clear how circulating E. coli crosses the blood-brain barrier. A TnphoA mutant of E. coli K1 RS218...
Stins, Monique F., Nemani, Prasadarao V., Wass, Carol, Kim, Kwang Sik
Escherichia coli meningitis commonly occurs in the neonatal period, but the basis of this age dependency is unclear. We have previously identified two types of E. coli-brain microvascular endothelial...
Prasadarao, Nemani V., Wass, Carol A., Stins, Monique F., Shimada, Hiroyuki, Kim, Kwang Sik
Escherichia coli is the most common gram-negative bacterium that causes meningitis during the neonatal period. We have previously shown that the entry of circulating E. coli organisms into the...
Streptococcus suis Serotype 2 Interactions with Human Brain Microvascular Endothelial Cells
Charland, Nathalie, Nizet, Victor, Rubens, Craig E., Kim, Kwang Sik, Lacouture, Sonia, Gottschalk, Marcelo
Streptococcus suis serotype 2 is a worldwide causative agent of many forms of swine infection and is also recognized as a zoonotic agent causing human disease, including meningitis. The pathogenesis...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Daniels, Justin, Kuhn, Michael
Internalization of Listeria monocytogenes into human brain microvascular endothelial cells (HBMEC) has recently been demonstrated to be dependent upon the inlB gene. In the present scanning electron...
Reddy, Marpadga A., Wass, Carol A., Kim, Kwang Sik, Schlaepfer, David D., Prasadarao, Nemani V.
Escherichia coli K1 traversal across the blood-brain barrier is an essential step in the pathogenesis of neonatal meningitis. We have previously shown that invasive E. coli promotes the actin...
Zysk, Gregor, Schneider-Wald, Barbara Katharina, Hwang, Jae Hyuk, Bejo, Levente, Kim, Kwang Sik, Mitchell, Timothy J., ...
In pneumococcal meningitis it is assumed that bacteria cross the blood-brain barrier (BBB), which consists mainly of cerebral endothelial cells. The effect of Streptococcus pneumoniae on the BBB was...
Traversal of Candida albicans across Human Blood-Brain Barrier In Vitro
Jong, Ambrose Y., Stins, Monique F., Huang, Sheng-He, Chen, Steven H. M., Kim, Kwang Sik
Candida albicans is an opportunistic pathogen, which primarily affects neonates and immunocompromised individuals. The pathogen can invade the central nervous system, resulting in meningitis. At...
Däubener, Walter, Spors, Birgit, Hucke, Christian, Adam, Rüdiger, Stins, Monique, Kim, Kwang Sik, ...
One of the first steps in the development of cerebral toxoplasmosis is the penetration of the blood-brain barrier, which is comprised of microvascular endothelial cells. We examined the capacity of...
Badger, Julie L., Wass, Carol A., Weissman, Scott J., Kim, Kwang Sik
Escherichia coli K1 is the leading cause of gram-negative bacterial meningitis in neonates. It is principally due to our limited understanding of the pathogenesis of this disease that the morbidity...
Hoffman, Jill A., Badger, Julie L., Zhang, Yan, Huang, Sheng-He, Kim, Kwang Sik
Neonatal Escherichia coli meningitis remains a devastating disease, with unacceptably high morbidity and mortality despite advances in supportive care measures and bactericidal antibiotics. To...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Weiglein, Inge, Bubert, Andreas, Engelbrecht, Fredi, ...
Invasion of endothelial tissues may be crucial in a Listeria monocytogenes infection leading to meningitis and/or encephalitis. Internalization of L. monocytogenes into endothelial cells has been...
Badger, Julie L., Kim, Kwang Sik
A major limitation to advances in prevention and therapy of neonatal meningitis is our incomplete understanding of the pathogenesis of this disease. In an effort to understand the pathogenesis of...
Huang, Sheng-He, Chen, Yu-Hua, Fu, Qi, Stins, Monique, Wang, Ying, Wass, Carol, ...
Escherichia coli K1 is the most common gram-negative organism causing neonatal meningitis, but the mechanism by which E. coli K1 crosses the blood-brain barrier is incompletely understood. We have...
Hoffman, Jill A., Wass, Carol, Stins, Monique F., Kim, Kwang Sik
The vast majority of cases of gram-negative meningitis in neonates are caused by K1-encapsulated Escherichia coli. The role of the K1 capsule in the pathogenesis of E. coli meningitis was examined...
Hertzig, Tobias, Weber, Martin, Greiffenberg, Lars, Holthausen, Britta Schulte, Goebel, Werner, Kim, Kwang Sik, ...
Listeria monocytogenes causes meningitis and encephalitis in humans and crosses the blood-brain barrier by yet unknown mechanisms. The interaction of the bacteria with different types of endothelial...
Prasadarao, Nemani V., Srivastava, Pramod K., Rudrabhatla, Rajyalakshmi S., Kim, Kwang Sik, Huang, Sheng-he, Sukumaran, Sunil K.
Escherichia coli is one of the most common gram-negative bacteria that cause meningitis in neonates. Our previous studies have shown that outer membrane protein A (OmpA) of E. coli interacts with a...
Importance of Medium in Demonstrating Penicillin Tolerance by Group B Streptococci
Kim, Kwang Sik, Yoshimori, Robert N., Imagawa, David T., Anthony, Bascom F.
A total of 30 clinical isolates of group B streptococci were studied for penicillin tolerance in vitro. Minimal inhibitory and bactericidal concentrations of penicillin were determined simultaneously...
Chang, Yun C., Stins, Monique F., McCaffery, Michael J., Miller, Georgina F., Pare, Dan R., Dam, Tapen, ...
Cryptococcal meningoencephalitis develops as a result of hematogenous dissemination of inhaled Cryptococcus neoformans from the lung to the brain. The mechanism(s) by which C. neoformans crosses the...
Hess, Petra, Altenhöfer, Artur, Khan, A. Salam, Daryab, Neda, Kim, Kwang Sik, Hacker, Jörg, ...
From the invasive Citrobacter freundii strain 3009, an invasion determinant was cloned, sequenced, and expressed. Sequence analysis of the determinant showed high homology with the fim determinant...
Chang, Yun C., Stins, Monique F., McCaffery, Michael J., Miller, Georgina F., Pare, Dan R., Dam, Tapen, ...
Borrelia burgdorferi, Host-Derived Proteases, and the Blood-Brain Barrier
Grab, Dennis J., Perides, George, Dumler, J. Stephen, Kim, Kee Jun, Park, Jinho, Kim, Yuri V., ...
Neurological manifestations of Lyme disease in humans are attributed in part to penetration of the blood-brain barrier (BBB) and invasion of the central nervous system (CNS) by Borrelia burgdorferi....
Sissons, James, Kim, Kwang Sik, Stins, Monique, Jayasekera, Samantha, Alsam, Selwa, Khan, Naveed Ahmed
Granulomatous amoebic encephalitis due to Acanthamoeba castellanii is a serious human infection with fatal consequences, but it is not clear how the circulating amoebae interact with the blood-brain...
Teng, Ching-Hao, Cai, Mian, Shin, Sooan, Xie, Yi, Kim, Kee-Jun, Khan, Naveed Ahmed, ...
Escherichia coli K1 is a major gram-negative organism causing neonatal meningitis. E. coli K1 binding to and invasion of human brain microvascular endothelial cells (HBMEC) are a prerequisite for E....
Borrelia burgdorferi, Host-Derived Proteases, and the Blood-Brain Barrier
Grab, Dennis J., Perides, George, Dumler, J. Stephen, Kim, Kee Jun, Park, Jinho, Kim, Yuri V., ...
Obojes, Karola, Andres, Oliver, Kim, Kwang Sik, Däubener, Walter, Schneider-Schaulies, Jürgen
Gamma interferon (IFN-γ) has been shown to be increased in sera from patients with acute measles and after vaccination, to exhibit protective functions in brains of patients with subacute sclerosing...
Di Cello, Francescopaolo, Xie, Yi, Paul-Satyaseela, Maneesh, Kim, Kwang Sik
We established a protocol for isolation of microarray-grade bacterial RNA from Escherichia coli K1 interacting with human brain microvascular endothelial cells. The extracted RNA was free of human...
Wu, Huixing, Kuzmenko, Alexander, Wan, Sijue, Schaffer, Lyndsay, Weiss, Alison, Fisher, James H., ...
The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been reported to bind lipopolysaccharide (LPS), opsonize microorganisms, and enhance the clearance of lung pathogens. In this...
Yao, Yufeng, Xie, Yi, Kim, Kwang Sik
Escherichia coli is a major cause of enteric/diarrheal diseases, urinary tract infections, and sepsis. E. coli K1 is the leading gram-negative organism causing neonatal meningitis, but the microbial...
Mange, Jean-Philippe, Stephan, Roger, Borel, Nicole, Wild, Peter, Kim, Kwang Sik, Pospischil, Andreas, ...
HbiF Regulates Type 1 Fimbriation Independently of FimB and FimE
Xie, Yi, Yao, Yufeng, Kolisnychenko, Vitaliy, Teng, Ching-Hao, Kim, Kwang Sik
Type 1 fimbriae have been suggested to play a role in the pathogenesis of extraintestinal Escherichia coli infection. Type 1 fimbriation in E. coli is phase variable and known to be dependent upon...
Prasadarao, Nemani V., Wass, Carol A., Huang, Sheng-He, Kim, Kwang Sik
The molecular basis of Escherichia coli traversal of the blood-brain barrier in the development of E. coli meningitis is not well understood. We have previously shown that a novel Ibe10 protein found...
Prasadarao, Nemani V., Lysenko, Elena, Wass, Carol A., Kim, Kwang Sik, Weiser, Jeffrey N.
Opacity-associated protein A (OapA), which is responsible for the transparent-colony phenotype of Haemophilus influenzae, has been implicated in the colonization of the nasopharynx in an infant rat...
Wang, Ying, Huang, Sheng-He, Wass, Carol A., Stins, Monique F., Kim, Kwang Sik
Most cases of Escherichia coli meningitis develop as a result of hematogenous spread, but it is not clear how circulating E. coli crosses the blood-brain barrier. A TnphoA mutant of E. coli K1 RS218...
Stins, Monique F., Nemani, Prasadarao V., Wass, Carol, Kim, Kwang Sik
Escherichia coli meningitis commonly occurs in the neonatal period, but the basis of this age dependency is unclear. We have previously identified two types of E. coli-brain microvascular endothelial...
Prasadarao, Nemani V., Wass, Carol A., Stins, Monique F., Shimada, Hiroyuki, Kim, Kwang Sik
Escherichia coli is the most common gram-negative bacterium that causes meningitis during the neonatal period. We have previously shown that the entry of circulating E. coli organisms into the...
Streptococcus suis Serotype 2 Interactions with Human Brain Microvascular Endothelial Cells
Charland, Nathalie, Nizet, Victor, Rubens, Craig E., Kim, Kwang Sik, Lacouture, Sonia, Gottschalk, Marcelo
Streptococcus suis serotype 2 is a worldwide causative agent of many forms of swine infection and is also recognized as a zoonotic agent causing human disease, including meningitis. The pathogenesis...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Daniels, Justin, Kuhn, Michael
Internalization of Listeria monocytogenes into human brain microvascular endothelial cells (HBMEC) has recently been demonstrated to be dependent upon the inlB gene. In the present scanning electron...
Reddy, Marpadga A., Wass, Carol A., Kim, Kwang Sik, Schlaepfer, David D., Prasadarao, Nemani V.
Escherichia coli K1 traversal across the blood-brain barrier is an essential step in the pathogenesis of neonatal meningitis. We have previously shown that invasive E. coli promotes the actin...
Zysk, Gregor, Schneider-Wald, Barbara Katharina, Hwang, Jae Hyuk, Bejo, Levente, Kim, Kwang Sik, Mitchell, Timothy J., ...
In pneumococcal meningitis it is assumed that bacteria cross the blood-brain barrier (BBB), which consists mainly of cerebral endothelial cells. The effect of Streptococcus pneumoniae on the BBB was...
Traversal of Candida albicans across Human Blood-Brain Barrier In Vitro
Jong, Ambrose Y., Stins, Monique F., Huang, Sheng-He, Chen, Steven H. M., Kim, Kwang Sik
Candida albicans is an opportunistic pathogen, which primarily affects neonates and immunocompromised individuals. The pathogen can invade the central nervous system, resulting in meningitis. At...
Däubener, Walter, Spors, Birgit, Hucke, Christian, Adam, Rüdiger, Stins, Monique, Kim, Kwang Sik, ...
One of the first steps in the development of cerebral toxoplasmosis is the penetration of the blood-brain barrier, which is comprised of microvascular endothelial cells. We examined the capacity of...
Badger, Julie L., Wass, Carol A., Weissman, Scott J., Kim, Kwang Sik
Escherichia coli K1 is the leading cause of gram-negative bacterial meningitis in neonates. It is principally due to our limited understanding of the pathogenesis of this disease that the morbidity...
Hoffman, Jill A., Badger, Julie L., Zhang, Yan, Huang, Sheng-He, Kim, Kwang Sik
Neonatal Escherichia coli meningitis remains a devastating disease, with unacceptably high morbidity and mortality despite advances in supportive care measures and bactericidal antibiotics. To...
Greiffenberg, Lars, Goebel, Werner, Kim, Kwang Sik, Weiglein, Inge, Bubert, Andreas, Engelbrecht, Fredi, ...
Invasion of endothelial tissues may be crucial in a Listeria monocytogenes infection leading to meningitis and/or encephalitis. Internalization of L. monocytogenes into endothelial cells has been...
Badger, Julie L., Kim, Kwang Sik
A major limitation to advances in prevention and therapy of neonatal meningitis is our incomplete understanding of the pathogenesis of this disease. In an effort to understand the pathogenesis of...
Huang, Sheng-He, Chen, Yu-Hua, Fu, Qi, Stins, Monique, Wang, Ying, Wass, Carol, ...
Escherichia coli K1 is the most common gram-negative organism causing neonatal meningitis, but the mechanism by which E. coli K1 crosses the blood-brain barrier is incompletely understood. We have...
Hoffman, Jill A., Wass, Carol, Stins, Monique F., Kim, Kwang Sik
The vast majority of cases of gram-negative meningitis in neonates are caused by K1-encapsulated Escherichia coli. The role of the K1 capsule in the pathogenesis of E. coli meningitis was examined...