Kim S. C. Weber

Specific Activation of Leukocyte β2 Integrins Lymphocyte Function–associated Antigen-1 and Mac-1 by Chemokines Mediated by Distinct Pathways via the α Subunit Cytoplasmic Domains

Weber, Kim S.C., Klickstein, Lloyd B., Weber, Christian

We show that CC chemokines induced a sustained increase in monocyte adhesion to intercellular adhesion molecule-1 that was mediated by Mac-1 (αMβ2) but not lymphocyte function–associated...

Dual Role of H-Ras in Regulation of Lymphocyte Function Antigen-1 Activity by Stromal Cell-derived Factor-1α: Implications for Leukocyte Transmigration

Weber, Kim S.C., Ostermann, Georg, Zernecke, Alma, Schröder, Andreas, Klickstein, Lloyd B., Weber, Christian

We investigated the role of H-Ras in chemokine-induced integrin regulation in leukocytes. Stimulation of Jurkat T cells with the CXC chemokine stromal cell-derived factor-1α (SDF-1α) resulted in a...

Cytohesin-1 regulates β-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1

Geiger, Christiane, Nagel, Wolfgang, Boehm, Thomas, Van Kooyk, Yvette, Figdor, Carl G., Kremmer, Elisabeth, ...

Intracellular signaling pathways, which regulate the interactions of integrins with their ligands, affect a wide variety of biological functions. Here we provide evidence of how cytohesin-1, an...

Specific Activation of Leukocyte β2 Integrins Lymphocyte Function–associated Antigen-1 and Mac-1 by Chemokines Mediated by Distinct Pathways via the α Subunit Cytoplasmic Domains

Weber, Kim S.C., Klickstein, Lloyd B., Weber, Christian

We show that CC chemokines induced a sustained increase in monocyte adhesion to intercellular adhesion molecule-1 that was mediated by Mac-1 (αMβ2) but not lymphocyte function–associated...

Dual Role of H-Ras in Regulation of Lymphocyte Function Antigen-1 Activity by Stromal Cell-derived Factor-1α: Implications for Leukocyte Transmigration

Weber, Kim S.C., Ostermann, Georg, Zernecke, Alma, Schröder, Andreas, Klickstein, Lloyd B., Weber, Christian

We investigated the role of H-Ras in chemokine-induced integrin regulation in leukocytes. Stimulation of Jurkat T cells with the CXC chemokine stromal cell-derived factor-1α (SDF-1α) resulted in a...

Cytohesin-1 regulates β-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1

Geiger, Christiane, Nagel, Wolfgang, Boehm, Thomas, Van Kooyk, Yvette, Figdor, Carl G., Kremmer, Elisabeth, ...

Intracellular signaling pathways, which regulate the interactions of integrins with their ligands, affect a wide variety of biological functions. Here we provide evidence of how cytohesin-1, an...