Kevin J. Lynch

Automatic Construction of Networks of Concepts Characterizing Document Databases (1997)

An Article Template, Hsinchun Chen, Kevin J. Lynch

We report results of a study that involved the creation of knowledge bases of concepts from large, operational textual databases. Two East-bloc computing knowledge bases, both based on a semantic...

Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X3 allosteric modulator, cibacron blue

Jarvis, Michael F, Wismer, Carol T, Schweitzer, Edmund, Yu, Haixia, Van Biesen, Tim, Lynch, Kevin J, ...

Exogenous ATP produces acute and localized pain in humans, and P2X receptor agonists elicit acute nociceptive behaviours in rodents following intradermal administration to the hindpaw. The...

2′, 3′-O-(2,4,6,Trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor

Neelands, Torben R, Burgard, Edward C, Uchic, Marie E, McDonald, Heath A, Niforatos, Wende, Faltynek, Connie R, ...

Rapid desensitization of ligand-gated ion channel receptors can alter the apparent activity of receptor modulators, as well as make detection of fast-channel activation difficult. Investigation of...