Small molecule modulation of Smoothened activity
Chen, James K., Taipale, Jussi, Young, Keith E., Maiti, Tapan, Beachy, Philip A.
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation...
Small molecule modulation of Smoothened activity
Chen, James K., Taipale, Jussi, Young, Keith E., Maiti, Tapan, Beachy, Philip A.
Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation...