Klockow,Boris, Tichelaar,Willem, Madden,Dean R., Niemann,Hartmut H., Akiba,Toshihiko, Hirose,Keiko, ...
Here we show that Dictyostelium discoideum dynamin A is a fast GTPase, binds to negatively charged lipids, and self-assembles into rings and helices in a nucleotide-dependent manner, similar to human...
Klockow, Boris, Tichelaar, Willem, Madden, Dean R., Niemann, Hartmut H., Akiba, Toshihiko, Hirose, Keiko, ...
Here we show that Dictyostelium discoideum dynamin A is a fast GTPase, binds to negatively charged lipids, and self-assembles into rings and helices in a nucleotide-dependent manner, similar to human...
Hirose, Keiko, Löwe, Jan, Alonso, Maria, Cross, Robert A., Amos, Linda A.
We present a new map showing dimeric kinesin bound to microtubules in the presence of ADP that was obtained by electron cryomicroscopy and image reconstruction. The directly bound monomer (first...
The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes
Klockow, Boris, Tichelaar, Willem, Madden, Dean R., Niemann, Hartmut H., Akiba, Toshihiko, Hirose, Keiko, ...
Here we show that Dictyostelium discoideum dynamin A is a fast GTPase, binds to negatively charged lipids, and self-assembles into rings and helices in a nucleotide-dependent manner, similar to human...
Coordination of kinesin's two heads studied with mutant heterodimers
Kaseda, Kuniyoshi, Higuchi, Hideo, Hirose, Keiko
A conventional kinesin molecule has two identical catalytic domains (heads) and is thought to use them alternately to move processively, with 8-nm steps. To clarify how each head contributes to the...
Hirose, Keiko, Henningsen, Ulrike, Schliwa, Manfred, Toyoshima, Chikashi, Shimizu, Takashi, Alonso, Maria, ...
Cryo-electron microscopy and 3D image reconstruction of microtubules saturated with kinesin dimers has shown one head bound to tubulin, the other free. The free head of rat kinesin sits on the top...
Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides
Solares, C. Arturo, Edling, Andrea E., Johnson, Justin M., Baek, Moo-Jin, Hirose, Keiko, Hughes, Gordon B., ...
Autoimmune sensorineural hearing loss (ASNHL) is characterized typically by bilateral, rapidly progressive hearing loss that responds therapeutically to corticosteroid treatment. Despite its name,...
A Bidirectional Kinesin Motor in Live Drosophila Embryos
Sciambi, Catherine J., Komma, Donald J., Sköld, Helén Nilsson, Hirose, Keiko, Endow, Sharyn A.
Spindle assembly and elongation involve poleward and away-from-the-pole forces produced by microtubule dynamics and spindle-associated motors. Here, we show that a bidirectional Drosophila Kinesin-14...
A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing
Rowe, Theresa M., Rizzi, Mark, Hirose, Keiko, Peters, Gregory A., Sen, Ganes C.
To determine the physiological functions of the mammalian double-stranded RNA-binding protein PACT, the single-copy mouse Pact gene was disrupted and expression of the protein was completely ablated....
Hirose, Keiko, Löwe, Jan, Alonso, Maria, Cross, Robert A., Amos, Linda A.
We present a new map showing dimeric kinesin bound to microtubules in the presence of ADP that was obtained by electron cryomicroscopy and image reconstruction. The directly bound monomer (first...
The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes
Klockow, Boris, Tichelaar, Willem, Madden, Dean R., Niemann, Hartmut H., Akiba, Toshihiko, Hirose, Keiko, ...
Here we show that Dictyostelium discoideum dynamin A is a fast GTPase, binds to negatively charged lipids, and self-assembles into rings and helices in a nucleotide-dependent manner, similar to human...
Coordination of kinesin's two heads studied with mutant heterodimers
Kaseda, Kuniyoshi, Higuchi, Hideo, Hirose, Keiko
A conventional kinesin molecule has two identical catalytic domains (heads) and is thought to use them alternately to move processively, with 8-nm steps. To clarify how each head contributes to the...
Hirose, Keiko, Henningsen, Ulrike, Schliwa, Manfred, Toyoshima, Chikashi, Shimizu, Takashi, Alonso, Maria, ...
Cryo-electron microscopy and 3D image reconstruction of microtubules saturated with kinesin dimers has shown one head bound to tubulin, the other free. The free head of rat kinesin sits on the top...
Murine autoimmune hearing loss mediated by CD4+ T cells specific for inner ear peptides
Solares, C. Arturo, Edling, Andrea E., Johnson, Justin M., Baek, Moo-Jin, Hirose, Keiko, Hughes, Gordon B., ...
Autoimmune sensorineural hearing loss (ASNHL) is characterized typically by bilateral, rapidly progressive hearing loss that responds therapeutically to corticosteroid treatment. Despite its name,...
A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing
Rowe, Theresa M., Rizzi, Mark, Hirose, Keiko, Peters, Gregory A., Sen, Ganes C.
To determine the physiological functions of the mammalian double-stranded RNA-binding protein PACT, the single-copy mouse Pact gene was disrupted and expression of the protein was completely ablated....
Orphan Glutamate Receptor δ1 Subunit Required for High-Frequency Hearing▿
Gao, Jiangang, Maison, Stéphane F., Wu, Xudong, Hirose, Keiko, Jones, Sherri M., Bayazitov, Ildar, ...
The function of the orphan glutamate receptor delta subunits (GluRδ1 and GluRδ2) remains unclear. GluRδ2 is expressed exclusively in the Purkinje cells of the cerebellum, and GluRδ1 is...
Sautter, Nathan B., Shick, Elizabeth H., Ransohoff, Richard M., Charo, Israel F., Hirose, Keiko
Acoustic trauma was recently shown to induce an inflammatory response in the ear characterized by rapid entry of macrophages in the spiral ligament. The current study seeks to elucidate the...