Kazuhiko Takahashi

Divergent Selection on Opsins Drives Incipient Speciation in Lake Victoria Cichlids (2006)

Yohey Terai, Ole Seehausen, Takeshi Sasaki, Kazuhiko Takahashi, Shinji Mizoiri, Tohru Sugawara, ...

Divergent natural selection acting on ecological traits, which also affect mate choice, is a key element of ecological speciation theory, but has not previously been demonstrated at the molecular...

Dietary, but not Topical, Alpha-linolenic Acid Suppresses UVB-induced Skin Injury in Hairless Mice when Compared with Linoleic Acid¶ (2002)

Naoya Takemura, Kazuhiko Takahashi, Hiroshi Tanaka, Yuka Ihara, Atsushi Ikemoto, Yoichi Fujii, ...

Peroxidizability of fatty acids in the air is roughly proportional to the number of double bonds, but in vivo peroxidation proceeds in a more complex manner. Here, we compared the effects of dietary...

Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

Takahashi, Kazuhiko, Suwa, Hiroaki, Ishikawa, Tomoo, Kotani, Hidehito

Histamine is an aminergic neurotransmitter that is localized in the CNS and in peripheral tissues. To date, four histamine receptors have been identified, and the H3 receptor, which was recently...

Bichir HoxA Cluster Sequence Reveals Surprising Trends in Ray-Finned Fish Genomic Evolution

Chiu, Chi-hua, Dewar, Ken, Wagner, Günter P., Takahashi, Kazuhiko, Ruddle, Frank, Ledje, Christina, ...

The study of Hox clusters and genes provides insights into the evolution of genomic regulation of development. Derived ray-finned fishes (Actinopterygii, Teleostei) such as zebrafish and pufferfish...

Domain structure of bi-functional selenoprotein P

Saito, Yoshiro, Sato, Noriko, Hirashima, Masaki, Takebe, Gen, Nagasawa, Shigeharu, Takahashi, Kazuhiko

Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region and the...

DJ-1 has a role in antioxidative stress to prevent cell death

Taira, Takahiro, Saito, Yoshiro, Niki, Takeshi, Takahashi, Kazuhiko, Ariga, Hiroyoshi

Deletion and point (L166P) mutations of DJ-1 have recently been shown to be responsible for the onset of familial Parkinson's disease (PD, PARK7). The aim of this study was to determine the role of...

Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

Takahashi, Kazuhiko, Suwa, Hiroaki, Ishikawa, Tomoo, Kotani, Hidehito

Histamine is an aminergic neurotransmitter that is localized in the CNS and in peripheral tissues. To date, four histamine receptors have been identified, and the H3 receptor, which was recently...

Bichir HoxA Cluster Sequence Reveals Surprising Trends in Ray-Finned Fish Genomic Evolution

Chiu, Chi-hua, Dewar, Ken, Wagner, Günter P., Takahashi, Kazuhiko, Ruddle, Frank, Ledje, Christina, ...

The study of Hox clusters and genes provides insights into the evolution of genomic regulation of development. Derived ray-finned fishes (Actinopterygii, Teleostei) such as zebrafish and pufferfish...

Domain structure of bi-functional selenoprotein P

Saito, Yoshiro, Sato, Noriko, Hirashima, Masaki, Takebe, Gen, Nagasawa, Shigeharu, Takahashi, Kazuhiko

Human selenoprotein P (SeP), a selenium-rich plasma glycoprotein, is presumed to contain ten selenocysteine residues; one of which is located at the 40th residue in the N-terminal region and the...

DJ-1 has a role in antioxidative stress to prevent cell death

Taira, Takahiro, Saito, Yoshiro, Niki, Takeshi, Takahashi, Kazuhiko, Ariga, Hiroyoshi

Deletion and point (L166P) mutations of DJ-1 have recently been shown to be responsible for the onset of familial Parkinson's disease (PD, PARK7). The aim of this study was to determine the role of...

Divergent Selection on Opsins Drives Incipient Speciation in Lake Victoria Cichlids

Terai, Yohey, Seehausen, Ole, Sasaki, Takeshi, Takahashi, Kazuhiko, Mizoiri, Shinji, Sugawara, Tohru, ...

Divergent natural selection acting on ecological traits, which also affect mate choice, is a key element of ecological speciation theory, but has not previously been demonstrated at the molecular...

Adaptive evolution of HoxA-11 and HoxA-13 at the origin of the uterus in mammals.

Lynch, Vincent J., Roth, Jutta J., Takahashi, Kazuhiko, Dunn, Casey W., Nonaka, Daisuke F., Stopper, Geffrey F., ...

The evolution of morphological characters is mediated by the evolution of developmental genes. Evolutionary changes can either affect cis-regulatory elements, leading to differences in their temporal...

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

Yoshimoto, Ryo, Miyamoto, Yasuhisa, Shimamura, Ken, Ishihara, Akane, Takahashi, Kazuhiko, Kotani, Hidehito, ...

Histamine H3 receptors (H3Rs) are located on the presynaptic membranes and cell soma of histamine neurons, where they negatively regulate the synthesis and release of histamine. In addition, H3Rs are...