Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
Matsuoka, Shuhei, Rotman, Galit, Ogawa, Akira, Shiloh, Yosef, Tamai, Katsuyuki, Elledge, Stephen J.
The protein kinase Chk2, the mammalian homolog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, is phosphorylated and activated in response to DNA damage by ionizing radiation...
Nakagawa, Kazumi, Taya, Yoichi, Tamai, Katsuyuki, Yamaizumi, Masaru
Microinjection of the restriction endonuclease HaeIII, which causes DNA double-strand breaks with blunt ends, induces nuclear accumulation of p53 protein in normal and xeroderma pigmentosum (XP)...
Mizuno, Takeshi, Ito, Nobutoshi, Yokoi, Masayuki, Kobayashi, Akio, Tamai, Katsuyuki, Miyazawa, Hiroshi, ...
DNA polymerase α-primase is a replication enzyme necessary for DNA replication in all eukaryotes examined so far. Mouse DNA polymerase α is made up of four subunits, the largest of which is the...
Shieh, Sheau-Yann, Ahn, Jinwoo, Tamai, Katsuyuki, Taya, Yoichi, Prives, Carol
Upon DNA damage, the amino terminus of p53 is phosphorylated at a number of serine residues including S20, a site that is particularly important in regulating stability and function of the protein....
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
Liu, Qinghua, Guntuku, Saritha, Cui, Xian-Shu, Matsuoka, Shuhei, Cortez, David, Tamai, Katsuyuki, ...
Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By gene disruption, we show that CHK1 deficiency results in a severe...
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
Sears, Rosalie, Nuckolls, Faison, Haura, Eric, Taya, Yoichi, Tamai, Katsuyuki, Nevins, Joseph R.
Our recent work has shown that activation of the Ras/Raf/ERK pathway extends the half-life of the Myc protein and thus enhances the accumulation of Myc activity. We have extended these observations...
Regulation of checkpoint kinases through dynamic interaction with Crb2
Mochida, Satoru, Esashi, Fumiko, Aono, Nobuki, Tamai, Katsuyuki, O'Connell, Matthew J, Yanagida, Mitsuhiro
ATR/Rad3-like kinases promote the DNA damage checkpoint through regulating Chk1 that restrains the activation of cyclin-dependent kinases. In fission yeast, Crb2, a BRCT-domain protein that is...
Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest
Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...
We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
Matsuoka, Shuhei, Rotman, Galit, Ogawa, Akira, Shiloh, Yosef, Tamai, Katsuyuki, Elledge, Stephen J.
The protein kinase Chk2, the mammalian homolog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, is phosphorylated and activated in response to DNA damage by ionizing radiation...
Nakagawa, Kazumi, Taya, Yoichi, Tamai, Katsuyuki, Yamaizumi, Masaru
Microinjection of the restriction endonuclease HaeIII, which causes DNA double-strand breaks with blunt ends, induces nuclear accumulation of p53 protein in normal and xeroderma pigmentosum (XP)...
Mizuno, Takeshi, Ito, Nobutoshi, Yokoi, Masayuki, Kobayashi, Akio, Tamai, Katsuyuki, Miyazawa, Hiroshi, ...
DNA polymerase α-primase is a replication enzyme necessary for DNA replication in all eukaryotes examined so far. Mouse DNA polymerase α is made up of four subunits, the largest of which is the...
Shieh, Sheau-Yann, Ahn, Jinwoo, Tamai, Katsuyuki, Taya, Yoichi, Prives, Carol
Upon DNA damage, the amino terminus of p53 is phosphorylated at a number of serine residues including S20, a site that is particularly important in regulating stability and function of the protein....
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
Liu, Qinghua, Guntuku, Saritha, Cui, Xian-Shu, Matsuoka, Shuhei, Cortez, David, Tamai, Katsuyuki, ...
Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By gene disruption, we show that CHK1 deficiency results in a severe...
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
Sears, Rosalie, Nuckolls, Faison, Haura, Eric, Taya, Yoichi, Tamai, Katsuyuki, Nevins, Joseph R.
Our recent work has shown that activation of the Ras/Raf/ERK pathway extends the half-life of the Myc protein and thus enhances the accumulation of Myc activity. We have extended these observations...
Regulation of checkpoint kinases through dynamic interaction with Crb2
Mochida, Satoru, Esashi, Fumiko, Aono, Nobuki, Tamai, Katsuyuki, O'Connell, Matthew J, Yanagida, Mitsuhiro
ATR/Rad3-like kinases promote the DNA damage checkpoint through regulating Chk1 that restrains the activation of cyclin-dependent kinases. In fission yeast, Crb2, a BRCT-domain protein that is...
Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest
Yabuta, Norikazu, Onda, Hiroaki, Watanabe, Masafumi, Yoshioka, Naohisa, Nagamori, Ippei, Funatsu, Tomoyuki, ...
We report here the isolation of 44 genes that are upregulated after serum starvation and/or contact inhibition. These genes have been termed TIGA, after Transcript Induced by Growth Arrest. We found...