Huang, Shixia, Li, Yi, Chen, Yidong, Podsypanina, Katrina, Chamorro, Mario, Olshen, Adam B, ...
Abstract Background In human breast cancer normal mammary cells typically develop into hyperplasia, ductal carcinoma in situ , invasive cancer, and metastasis. The changes in gene expression...
Podsypanina, Katrina, Li, Yi, Varmus, Harold E
Abstract Background MMTV-Wnt1 transgenic mice develop mammary hyperplasia early in development, followed by the appearance of solitary mammary tumors with a high proportion of cells expressing early...
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice (2001)
Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, ...
Abstract Background Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast...
The PTEN tumor suppressor and effects of Pten disruption in mice (2000)
Cancer is the second leading cause of death in the United States. Neoplastic transformation is caused by genetic and epigenetic alterations in tumor suppressor genes or protooncogenes. This thesis...
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
Mayford, Mark, Baranes, Danny, Podsypanina, Katrina, Kandel, Eric R.
Neuronal signaling requires that synaptic proteins be appropriately localized within the cell and regulated there. In mammalian neurons, polyribosomes are found not just in the cell body, but also in...
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, ...
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice
Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, ...
PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary...
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
Kwabi-Addo, Bernard, Giri, Dipak, Schmidt, Karen, Podsypanina, Katrina, Parsons, Ramon, Greenberg, Norman, ...
The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of...
Li, Yi, Welm, Bryan, Podsypanina, Katrina, Huang, Shixia, Chamorro, Mario, Zhang, Xiaomei, ...
Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood....
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
Huang, Shixia, Li, Yi, Chen, Yidong, Podsypanina, Katrina, Chamorro, Mario, Olshen, Adam B, ...
cDNA microarray-derived expression profiles of MMTV-Wnt-1 and MMTV-Neu transgenic mice reveal several hundred genes to be differentially expressed at each stage of breast tumor development.
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
Mayford, Mark, Baranes, Danny, Podsypanina, Katrina, Kandel, Eric R.
Neuronal signaling requires that synaptic proteins be appropriately localized within the cell and regulated there. In mammalian neurons, polyribosomes are found not just in the cell body, but also in...
Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, ...
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice
Podsypanina, Katrina, Lee, Richard T., Politis, Chris, Hennessy, Ian, Crane, Allison, Puc, Janusz, ...
PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary...
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
Kwabi-Addo, Bernard, Giri, Dipak, Schmidt, Karen, Podsypanina, Katrina, Parsons, Ramon, Greenberg, Norman, ...
The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of...
Li, Yi, Welm, Bryan, Podsypanina, Katrina, Huang, Shixia, Chamorro, Mario, Zhang, Xiaomei, ...
Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood....
Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
Huang, Shixia, Li, Yi, Chen, Yidong, Podsypanina, Katrina, Chamorro, Mario, Olshen, Adam B, ...
cDNA microarray-derived expression profiles of MMTV-Wnt-1 and MMTV-Neu transgenic mice reveal several hundred genes to be differentially expressed at each stage of breast tumor development.
Du, Zhijun, Podsypanina, Katrina, Huang, Shixia, McGrath, Amanda, Toneff, Michael J., Bogoslovskaia, Ekaterina, ...
We have adapted the avian leukosis virus RCAS (replication-competent avian sarcoma-leukosis virus LTR splice acceptor)-mediated somatic gene transfer technique to introduce oncogenes into mammary...
DNA Mismatch Repair Deficiency Accelerates Endometrial Tumorigenesis in Pten Heterozygous Mice
Wang, Hong, Douglas, Wayne, Lia, Marie, Edelmann, Winfried, Kucherlapati, Raju, Podsypanina, Katrina, ...
PTEN mutation and microsatellite instability are two of the most common genetic alterations in uterine endometrioid carcinoma. Furthermore, previous studies have suggested an association between the...
Huang, Shixia, Chen, Yidong, Podsypanina, Katrina, Li, Yi
Distant metastases of human breast cancers have been suggested to be more different from each other than from their respective primary tumors, based on expression profiling. The mechanism behind this...
Podsypanina, Katrina, Politi, Katerina, Beverly, Levi J., Varmus, Harold E.
Most, if not all, cancers are composed of cells in which more than one gene has a cancer-promoting mutation. Although recent evidence has shown the benefits of therapies targeting a single mutant...