Katja Pfafferott

Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection†

Pillay, Thillagavathie, Zhang, Hua-Tang, Drijfhout, Jan W., Robinson, Nicola, Brown, Helen, Khan, Munira, ...

The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant...

Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1

Martinez-Picado, Javier, Prado, Julia G., Fry, Elizabeth E., Pfafferott, Katja, Leslie, Alasdair, Chetty, Senica, ...

Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may...

Unique Acquisition of Cytotoxic T-Lymphocyte Escape Mutants in Infant Human Immunodeficiency Virus Type 1 Infection†

Pillay, Thillagavathie, Zhang, Hua-Tang, Drijfhout, Jan W., Robinson, Nicola, Brown, Helen, Khan, Munira, ...

The role of cytotoxic T-lymphocyte (CTL) escape in rapidly progressive infant human immunodeficiency virus type 1 (HIV-1) infection is undefined. The data presented here demonstrate that infant...

Fitness Cost of Escape Mutations in p24 Gag in Association with Control of Human Immunodeficiency Virus Type 1

Martinez-Picado, Javier, Prado, Julia G., Fry, Elizabeth E., Pfafferott, Katja, Leslie, Alasdair, Chetty, Senica, ...

Mutational escape by human immunodeficiency virus (HIV) from cytotoxic T-lymphocyte (CTL) recognition is a major challenge for vaccine design. However, recent studies suggest that CTL escape may...

Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection

Gaudieri, Silvana, Rauch, Andri, Park, Lawrence P., Freitas, Elizabeth, Herrmann, Susan, Jeffrey, Gary, ...

Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted...

Mutually Exclusive T-Cell Receptor Induction and Differential Susceptibility to Human Immunodeficiency Virus Type 1 Mutational Escape Associated with a Two-Amino-Acid Difference between HLA Class I Subtypes▿

Yu, Xu G., Lichterfeld, Mathias, Chetty, Senica, Williams, Katie L., Mui, Stanley K., Miura, Toshiyuki, ...

The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention of mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific...

Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection

Gaudieri, Silvana, Rauch, Andri, Park, Lawrence P., Freitas, Elizabeth, Herrmann, Susan, Jeffrey, Gary, ...

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA

Leslie, Alasdair, Kavanagh, Daniel, Honeyborne, Isobella, Pfafferott, Katja, Edwards, Charles, Pillay, Tilly, ...

Human immunodeficiency virus (HIV)-1 amino acid sequence polymorphisms associated with expression of specific human histocompatibility leukocyte antigen (HLA) class I alleles suggest sites of...