Tripathi, Timir, Rahlfs, Stefan, Becker, Katja, Bhakuni, Vinod
Abstract Background In contrast to many other organisms, the malarial parasite Plasmodium falciparum possesses only one typical glutathione S -transferase. This enzyme, Pf GST, cannot be assigned to...
Molekulare Maschinen und Alterung : der humane Redoxstoffwechsel (2007)
Oxidativer Stress ist an der Entstehung von degenerativen Erkrankungen, von Infektionskrankheiten sowie von Alterungsprozessen beteiligt. Reaktive und damit potentiell giftige Sauerstoffverbindungen...
The Plasmodium selenoproteome (2006)
Lobanov, Alexey V., Delgado, Cesar, Rahlfs, Stefan, Novoselov, Sergey V., Kryukov, Gregory V., Gromer, Stephan, ...
The use of selenocysteine (Sec) as the 21st amino acid in the genetic code has been described in all three major domains of life. However, within eukaryotes, selenoproteins are only known in animals...
Hiller, Nicole, Fritz−Wolf, Karin, Deponte, Marcel, Wende, Wolfgang, Zimmermann, Herbert, Becker, Katja
Glutathione S−transferase of the malarial parasite Plasmodium falciparum (PfGST) represents a novel class of GST isoenzymes. Since the architecture of the PfGST substrate binding site differs...
Hiller, Nicole, Fritz−Wolf, Karin, Deponte, Marcel, Wende, Wolfgang, Zimmermann, Herbert, Becker, Katja
Glutathione S−transferase of the malarial parasite Plasmodium falciparum (PfGST) represents a novel class of GST isoenzymes. Since the architecture of the PfGST substrate binding site differs...
Ginger, Michael L., Ngazoa, E. Solange, Pereira, Claudio A., Pullen, Timothy J., Kabiri, Mostafa, Becker, Katja, ...
Adenylate kinases occur classically as cytoplasmic and mitochondrial enzymes, but the expression of seven adenylate kinases in the flagellated protozoan parasite Trypanosoma brucei (order,...
Deponte, Marcel, Urig, Sabine, Arscott, L. David, Fritz−Wolf, Karin, Réau, Régis, Herold−Mende, Christel, ...
The homodimeric flavoprotein glutathione reductase (GR) is a central player of cellular redox metabolism, connecting NADPH to the large pool of redox−active thiols. In this work, the inhibition of...
X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum (2003)
Fritz-Wolf,Karin, Becker,Andreas, Rahlfs,Stefan, Harwaldt,Petra, Schirmer,R. Heiner, Kabsch,Wolfgang, ...
GSTs catalyze the conjugation of glutathione with a wide variety of hydrophobic compounds, generally resulting in nontoxic products that can be readily eliminated. In contrast to many other...
X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum (2003)
Fritz-Wolf, Karin, Becker, Andreas, Rahlfs, Stefan, Harwaldt, Petra, Schirmer, R. Heiner, Kabsch, Wolfgang, ...
GSTs catalyze the conjugation of glutathione with a wide variety of hydrophobic compounds, generally resulting in nontoxic products that can be readily eliminated. In contrast to many other...
Heidelberg, Univ., Diss., 1991 (Nicht für den Austausch).
Arscott, L. David, Gromer, Stephan, Schirmer, R. Heiner, Becker, Katja, Williams, Charles H.
Thioredoxin reductase, lipoamide dehydrogenase, and glutathione reductase are members of the pyridine nucleotide–disulfide oxidoreductase family of dimeric flavoenzymes. The mechanisms and...
X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum
Fritz-Wolf, Karin, Becker, Andreas, Rahlfs, Stefan, Harwaldt, Petra, Schirmer, R. Heiner, Kabsch, Wolfgang, ...
GSTs catalyze the conjugation of glutathione with a wide variety of hydrophobic compounds, generally resulting in nontoxic products that can be readily eliminated. In contrast to many other...
Waller, Frank, Achatz, Beate, Baltruschat, Helmut, Fodor, József, Becker, Katja, Fischer, Marina, ...
Disease resistance strategies are powerful approaches to sustainable agriculture because they reduce chemical input into the environment. Recently, Piriformospora indica, a plant-root-colonizing...
Akoachere, Monique, Buchholz, Kathrin, Fischer, Elisabeth, Burhenne, Jürgen, Haefeli, Walter E., Schirmer, R. Heiner, ...
Methylene blue (MB) represents a promising antimalarial drug candidate for combination therapies against drug-resistant parasite strains. To support and facilitate the application of MB in future...
Lobanov, Alexey V., Delgado, Cesar, Rahlfs, Stefan, Novoselov, Sergey V., Kryukov, Gregory V., Gromer, Stephan, ...
The use of selenocysteine (Sec) as the 21st amino acid in the genetic code has been described in all three major domains of life. However, within eukaryotes, selenoproteins are only known in animals...
Arscott, L. David, Gromer, Stephan, Schirmer, R. Heiner, Becker, Katja, Williams, Charles H.
Thioredoxin reductase, lipoamide dehydrogenase, and glutathione reductase are members of the pyridine nucleotide–disulfide oxidoreductase family of dimeric flavoenzymes. The mechanisms and...
X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum
Fritz-Wolf, Karin, Becker, Andreas, Rahlfs, Stefan, Harwaldt, Petra, Schirmer, R. Heiner, Kabsch, Wolfgang, ...
GSTs catalyze the conjugation of glutathione with a wide variety of hydrophobic compounds, generally resulting in nontoxic products that can be readily eliminated. In contrast to many other...
Waller, Frank, Achatz, Beate, Baltruschat, Helmut, Fodor, József, Becker, Katja, Fischer, Marina, ...
Disease resistance strategies are powerful approaches to sustainable agriculture because they reduce chemical input into the environment. Recently, Piriformospora indica, a plant-root-colonizing...
Akoachere, Monique, Buchholz, Kathrin, Fischer, Elisabeth, Burhenne, Jürgen, Haefeli, Walter E., Schirmer, R. Heiner, ...
Methylene blue (MB) represents a promising antimalarial drug candidate for combination therapies against drug-resistant parasite strains. To support and facilitate the application of MB in future...
Lobanov, Alexey V., Delgado, Cesar, Rahlfs, Stefan, Novoselov, Sergey V., Kryukov, Gregory V., Gromer, Stephan, ...
The use of selenocysteine (Sec) as the 21st amino acid in the genetic code has been described in all three major domains of life. However, within eukaryotes, selenoproteins are only known in animals...
Hiller, Nicole, Fritz-Wolf, Karin, Deponte, Marcel, Wende, Wolfgang, Zimmermann, Herbert, Becker, Katja
Glutathione S-transferase of the malarial parasite Plasmodium falciparum (PfGST) represents a novel class of GST isoenzymes. Since the architecture of the PfGST substrate binding site differs...
Buchholz, Kathrin, Schirmer, R. Heiner, Eubel, Jana K., Akoachere, Monique B., Dandekar, Thomas, Becker, Katja, ...
Methylene blue (MB) has experienced a renaissance mainly as a component of drug combinations against Plasmodium falciparum malaria. Here, we report biochemically relevant pharmacological data on MB...
Buchholz, Kathrin, Rahlfs, Stefan, Schirmer, R. Heiner, Becker, Katja, Matuschewski, Kai
Proliferation of the pathogenic Plasmodium asexual blood stages in host erythrocytes requires an exquisite capacity to protect the malaria parasite against oxidative stress. This function is achieved...