Comparative analysis of sequence features involved in the recognition of tandem splice sites (2008)
Bortfeldt, Ralf, Schindler, Stefanie, Szafranski, Karol, Schuster, Stefan, Holste, Dirk
Abstract Background The splicing of pre-mRNAs is conspicuously often variable and produces multiple alternatively spliced (AS) isoforms that encode different messages from one gene locus....
Schindler, Stefanie, Szafranski, Karol, Hiller, Michael, Ali, Gul, Palusa, Saiprasad G, Backofen, Rolf, ...
Abstract Background Several recent studies indicate that alternative splicing in Arabidopsis and other plants is a common mechanism for post-transcriptional modulation of gene expression. However,...
Selection against tandem splice sites affecting structured protein regions (2008)
Hiller, Michael, Szafranski, Karol, Huse, Klaus, Backofen, Rolf, Platzer, Matthias
Abstract Background Alternative selection of splice sites in tandem donors and acceptors is a major mode of alternative splicing. Here, we analyzed whether in-frame tandem sites leading to subtle...
Szafranski, Karol, Schindler, Stefanie, Taudien, Stefan, Hiller, Michael, Huse, Klaus, Jahn, Niels, ...
Abstract Background Despite some degeneracy of sequence signals that govern splicing of eukaryotic pre-mRNAs, it is an accepted rule that U2-dependent introns exhibit the 3' terminal dinucleotide AG....
Alternative Splicing at NAGNAG Acceptors: Simply Noise or Noise and More? (2006)
Michael Hiller, Karol Szafranski, Rolf Backofen, Matthias Platzer
Phylogenetically widespread alternative splicing at unusual GYNGYN donors (2006)
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schreiber, Stefan, Backofen, Rolf, ...
Abstract Background Splice donor sites have a highly conserved GT or GC dinucleotide and an extended intronic consensus sequence GTRAGT that reflects the sequence complementarity to the U1 snRNA....
The Dictyosteliumgenome encodes numerous RasGEFs with multiple biological roles (2005)
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
Abstract Background Dictyostelium discoideum is a eukaryote with a simple lifestyle and a relatively small genome whose sequence has been fully determined. It is widely used for studies on cell...
Taudien, Stefan, Galgoczy, Petra, Huse, Klaus, Reichwald, Kathrin, Schilhabel, Markus, Szafranski, Karol, ...
Abstract Background Defensins are important components of innate immunity to combat bacterial and viral infections, and can even elicit antitumor responses. Clusters of defensin (DEF) genes are...
Die Transposons im Genom von Dictyostelium discoideum / (2002)
Jena, Universiẗat, Diss., 2002 (Nicht für den Austausch).
The Complex Repeats of Dictyostelium discoideum
Glöckner, Gernot, Szafranski, Karol, Winckler, Thomas, Dingermann, Theodor, Quail, Michael A., Cox, Edward, ...
In the course of determining the sequence of the Dictyostelium discoideum genome we have characterized in detail the quantity and nature of interspersed repetitive elements present in this species....
Taudien, Stefan, Galgoczy, Petra, Huse, Klaus, Reichwald, Kathrin, Schilhabel, Markus, Szafranski, Karol, ...
The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
A survey of the Dictyostelium genome reveals at least 25 RasGEFs, all of which appear to be expressed at some point in development. Disruption of several of these novel RasGEFs reveals that many have...
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Jahn, Niels, Hampe, Jochen, Schreiber, Stefan, ...
Aberrant or modified splicing patterns of genes are causative for many human diseases. Therefore, the identification of genetic variations that cause changes in the splicing pattern of a gene is...
Alternative Splicing at NAGNAG Acceptors: Simply Noise or Noise and More?
Hiller, Michael, Szafranski, Karol, Backofen, Rolf, Platzer, Matthias
The Complex Repeats of Dictyostelium discoideum
Glöckner, Gernot, Szafranski, Karol, Winckler, Thomas, Dingermann, Theodor, Quail, Michael A., Cox, Edward, ...
In the course of determining the sequence of the Dictyostelium discoideum genome we have characterized in detail the quantity and nature of interspersed repetitive elements present in this species....
Taudien, Stefan, Galgoczy, Petra, Huse, Klaus, Reichwald, Kathrin, Schilhabel, Markus, Szafranski, Karol, ...
The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles
Wilkins, Andrew, Szafranski, Karol, Fraser, Derek J, Bakthavatsalam, Deenadayalan, Müller, Rolf, Fisher, Paul R, ...
A survey of the Dictyostelium genome reveals at least 25 RasGEFs, all of which appear to be expressed at some point in development. Disruption of several of these novel RasGEFs reveals that many have...
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Jahn, Niels, Hampe, Jochen, Schreiber, Stefan, ...
Aberrant or modified splicing patterns of genes are causative for many human diseases. Therefore, the identification of genetic variations that cause changes in the splicing pattern of a gene is...
Alternative Splicing at NAGNAG Acceptors: Simply Noise or Noise and More?
Hiller, Michael, Szafranski, Karol, Backofen, Rolf, Platzer, Matthias
Phylogenetically widespread alternative splicing at unusual GYNGYN donors
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schreiber, Stefan, Backofen, Rolf, ...
Computational and experimental evidence is given for alternative splicing at the unusual GYNGYN motif in several species, enabling in most cases subtle protein variations.
TassDB: a database of alternative tandem splice sites
Hiller, Michael, Nikolajewa, Swetlana, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schuster, Stefan, ...
Subtle alternative splice events at tandem splice sites are frequent in eukaryotes and substantially increase the complexity of transcriptomes and proteomes. We have developed a relational database,...
Selection against tandem splice sites affecting structured protein regions
Hiller, Michael, Szafranski, Karol, Huse, Klaus, Backofen, Rolf, Platzer, Matthias
Szafranski, Karol, Schindler, Stefanie, Taudien, Stefan, Hiller, Michael, Huse, Klaus, Jahn, Niels, ...
TG dinucleotides functioning as alternative 3' splice sites were identified and experimentally verified in 36 human genes.
Schindler, Stefanie, Szafranski, Karol, Hiller, Michael, Ali, Gul Shad, Palusa, Saiprasad G, Backofen, Rolf, ...
Comparative analysis of sequence features involved in the recognition of tandem splice sites
Bortfeldt, Ralf, Schindler, Stefanie, Szafranski, Karol, Schuster, Stefan, Holste, Dirk
Assessing the fraction of short-distance tandem splice sites under purifying selection
Hiller, Michael, Szafranski, Karol, Sinha, Rileen, Huse, Klaus, Nikolajewa, Swetlana, Rosenstiel, Philip, ...
Many alternative splice events result in subtle mRNA changes, and most of them occur at short-distance tandem donor and acceptor sites. The splicing mechanism of such tandem sites likely involves the...