Karin M. L. Gaensler

Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb βs-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, ...

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional...

Sequences in the Aγ–δ intergenic region are not required for stage-specific regulation of the human β-globin gene locus

Gaensler, Karin M. L., Zhang, Zemin, Lin, Chin, Yang, Suya, Hardt, Karin, Flebbe-Rehwaldt, Linda

The human β-globin locus has been extensively studied as a model of tissue and developmental stage-specific gene expression. Structural mapping of naturally occurring mutations, including...

Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb βs-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, ...

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional...

Sequences in the Aγ–δ intergenic region are not required for stage-specific regulation of the human β-globin gene locus

Gaensler, Karin M. L., Zhang, Zemin, Lin, Chin, Yang, Suya, Hardt, Karin, Flebbe-Rehwaldt, Linda

The human β-globin locus has been extensively studied as a model of tissue and developmental stage-specific gene expression. Structural mapping of naturally occurring mutations, including...

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivo

Basu, Priyadarshi, Morris, Pamela E., Haar, Jack L., Wani, Maqsood A., Lingrel, Jerry B., Gaensler, Karin M. L., ...

The Krüppel-like factors (KLFs) are a family of C2/H2 zinc finger DNA-binding proteins that are important in controlling developmental programs. Erythroid Krüppel-like factor (EKLF or KLF1)...