Karen P. Wedaman

Two Heteromeric Kinesin Complexes in Chemosensory Neurons and Sensory Cilia of Caenorhabditis elegans

Signor, Dawn, Wedaman, Karen P., Rose, Lesilee S., Scholey, Jonathan M.

Chemosensation in the nervous system of the nematode Caenorhabditis elegans depends on sensory cilia, whose assembly and maintenance requires the transport of components such as axonemal proteins and...

Tor Kinases Are in Distinct Membrane-associated Protein Complexes in Saccharomyces cerevisiae

Wedaman, Karen P., Reinke, Aaron, Anderson, Scott, Yates, John, McCaffery, J. Michael, Powers, Ted

Tor1p and Tor2p kinases, targets of the immune-suppressive antibiotic rapamycin, are components of a highly conserved signaling network that couples nutrient availability and cell growth. To gain...

Two Heteromeric Kinesin Complexes in Chemosensory Neurons and Sensory Cilia of Caenorhabditis elegans

Signor, Dawn, Wedaman, Karen P., Rose, Lesilee S., Scholey, Jonathan M.

Chemosensation in the nervous system of the nematode Caenorhabditis elegans depends on sensory cilia, whose assembly and maintenance requires the transport of components such as axonemal proteins and...

Tor Kinases Are in Distinct Membrane-associated Protein Complexes in Saccharomyces cerevisiae

Wedaman, Karen P., Reinke, Aaron, Anderson, Scott, Yates, John, McCaffery, J. Michael, Powers, Ted

Tor1p and Tor2p kinases, targets of the immune-suppressive antibiotic rapamycin, are components of a highly conserved signaling network that couples nutrient availability and cell growth. To gain...

Role of a Class Dhc1b Dynein in Retrograde Transport of Ift Motors and Ift Raft Particles along Cilia, but Not Dendrites, in Chemosensory Neurons of Living Caenorhabditis elegans

Signor, Dawn, Wedaman, Karen P., Orozco, Jose T., Dwyer, Noelle D., Bargmann, Cornelia I., Rose, Lesilee S., ...

The heterotrimeric motor protein, kinesin-II, and its presumptive cargo, can be observed moving anterogradely at 0.7 μm/s by intraflagellar transport (IFT) within sensory cilia of chemosensory...

Mechanism of Metabolic Control: Target of Rapamycin Signaling Links Nitrogen Quality to the Activity of the Rtg1 and Rtg3 Transcription Factors

Komeili, Arash, Wedaman, Karen P., O'Shea, Erin K., Powers, Ted

De novo biosynthesis of amino acids uses intermediates provided by the TCA cycle that must be replenished by anaplerotic reactions to maintain the respiratory competency of the cell. Genome-wide...

A Kinesin-Related Protein, Krp180, Positions Prometaphase Spindle Poles during Early Sea Urchin Embryonic Cell Division

Rogers, Gregory C., Chui, Kitty K., Lee, Edwin W., Wedaman, Karen P., Sharp, David J., Holland, Gina, ...

We have investigated the intracellular roles of an Xklp2-related kinesin motor, KRP180, in positioning spindle poles during early sea urchin embryonic cell division using quantitative, real-time...