Jeon, Mili, Nguyen, Huong, Bahri, Sami, Zinn, Kai
Background: Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in...
Jeon, Mili, Nguyen, Huong, Bahri, Sami, Zinn, Kai
Abstract Background Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in...
Sherwood, Nina Tang, Sun, Qi, Xue, Mingshan, Zhang, Bing, Zinn, Kai
The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to...
Nina Tang Sherwood, Qi Sun, Mingshan Xue, Bing Zhang, Kai Zinn
Kai Zinn and colleagues use loss- and gain-of function mutations to study the Drosophila homologue of a gene mutated in human autosomal dominant hereditary spastic paraplegia.
Nina Tang Sherwood, Qi Sun, Mingshan Xue, Bing Zhang, Kai Zinn
The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to...
Sun, Qi, Bahri, Sami, Schmid, Aloisia, Chia, William, Zinn, Kai
Neural receptor-linked protein tyrosine phosphatases (RPTPs) are required for guidance of motoneuron and photoreceptor growth cones in Drosophila. These phosphatases have not been implicated in...
We have begun to explore the downstream signaling pathways of receptor protein tyrosine phosphatases (RPTPs) that control axon guidance decisions in the Drosophila central nervous system. We have...
Zhang, Yinong, Chou, Joseph H., Bradley, Jonathan, Bargmann, Cornelia I., Zinn, Kai
The nematode Caenorhabditis elegans exhibits behavioral responses to many volatile odorants. Chemotaxis toward one such odorant, diacetyl (butanedione), requires the function of a seven-transmembrane...
Bradley, Jonathan, Li, Jun, Davidson, Norman, Lester, Henry A., Zinn, Kai
Olfactory receptor neurons respond to odorant stimulation with a rapid increase in intracellular cAMP that opens cyclic nucleotide-gated (cng) cation channels. cng channels in rat olfactory neurons...
Characterization and cloning of fasciclin I and fasciclin II glycoproteins in the grasshopper (1988)
Snow, Peter M., Zinn, Kai, Harrelson, Allan L., McAllister, Linda, Schilling, Jim, Bastiani, Michael J., ...
Monoclonal antibodies were previously used to identify two glycoproteins, called fasciclin I and II (70 and 95 kDa, respectively), which are expressed on different subsets of axon fascicles in the...
Regulated expression of an extrachromosomal human β-interferon gene in mouse cells (1982)
Zinn, Kai, Mellon, Pamela, Ptashne, Mark, Maniatis, Tom
β (fibroblast)-interferon mRNA and protein are induced by the synthetic double-stranded RNA poly(I)·poly(C) in cultured human fibroblasts. To study the mechanism of this induction, we have isolated...
Zhang, Yinong, Chou, Joseph H., Bradley, Jonathan, Bargmann, Cornelia I., Zinn, Kai
The nematode Caenorhabditis elegans exhibits behavioral responses to many volatile odorants. Chemotaxis toward one such odorant, diacetyl (butanedione), requires the function of a seven-transmembrane...
Drosophila Spastin Regulates Synaptic Microtubule Networks and Is Required for Normal Motor Function
Sherwood, Nina Tang, Sun, Qi, Xue, Mingshan, Zhang, Bing, Zinn, Kai
The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to...
Zhang, Yinong, Chou, Joseph H., Bradley, Jonathan, Bargmann, Cornelia I., Zinn, Kai
The nematode Caenorhabditis elegans exhibits behavioral responses to many volatile odorants. Chemotaxis toward one such odorant, diacetyl (butanedione), requires the function of a seven-transmembrane...
Drosophila Spastin Regulates Synaptic Microtubule Networks and Is Required for Normal Motor Function
Sherwood, Nina Tang, Sun, Qi, Xue, Mingshan, Zhang, Bing, Zinn, Kai
The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to...
Kinesin Light Chains Are Essential for Axonal Transport in Drosophila
Gindhart, Joseph G., Desai, Chand J., Beushausen, Sven, Zinn, Kai, Goldstein, Lawrence S.B.
Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light...