Jussi Taipale

Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling (2008)

Varjosalo, Markku, Björklund, Mikael, Cheng, Fang, Syvänen, Heidi, Kivioja, Teemu, Kilpinen, Sami, ...

Cell Vol.133, 537 - 548

Minimizing the risk of reporting false positives in large-scale RNAi screens (2006)

Echeverri, Christophe J, Beachy, Philip A, Baum, Buzz, Boutros, Michael, Buchholz, Frank, Chanda, Sumit K, ...

Large-scale RNA interference (RNAi)-based analyses, very much as other 'omic' approaches, have inherent rates of false positives and negatives. The variability in the standards of care applied to...

Latent transforming growth factor-[BETA] as a component of the extracellular matrix / (1996)

Taipale, Jussi.

Diss. -- Helsingin yliopisto.

Hepatocyte Growth Factor Releases Mink Epithelial Cells from Transforming Growth Factor β1-Induced Growth Arrest by Restoring Cdk6 Expression and Cyclin E-Associated Cdk2 Activity

Tsubari, Minna, Taipale, Jussi, Tiihonen, Erja, Keski-Oja, Jorma, Laiho, Marikki

Transforming growth factor β (TGF-β) potently suppresses Mv1Lu mink epithelial cell growth, whereas hepatocyte growth factor (HGF) counteracts TGF-β-mediated growth inhibition and induces Mv1Lu...

Small molecule modulation of Smoothened activity

Chen, James K., Taipale, Jussi, Young, Keith E., Maiti, Tapan, Beachy, Philip A.

Smoothened (Smo), a distant relative of G protein-coupled receptors, mediates Hedgehog (Hh) signaling during embryonic development and can initiate or transmit ligand-independent pathway activation...

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Chen, James K., Taipale, Jussi, Cooper, Michael K., Beachy, Philip A.

The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show here,...

VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer

Valtola, Reija, Salven, Petri, Heikkilä, Päivi, Taipale, Jussi, Joensuu, Heikki, Rehn, Marko, ...

Recently, monoclonal antibodies against the human vascular endothelial growth factor receptor VEGFR-3 were shown to provide a specific antigenic marker for lymphatic endothelium in various normal...

Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos▿

Haiko, Paula, Makinen, Taija, Keskitalo, Salla, Taipale, Jussi, Karkkainen, Marika J., Baldwin, Megan E., ...

Lymphatic vessels play an important role in the regulation of tissue fluid balance, immune responses, and fat adsorption and are involved in diseases including lymphedema and tumor metastasis....