Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
Zhang, Yi, Griffith, Eric C., Sage, Julien, Jacks, Tyler, Liu, Jun O.
Angiogenesis has been demonstrated to be essential for tumor growth and metastasis, and inhibition of angiogenesis is emerging as a promising strategy for treating cancer. Among the most potent...
p53-independent apoptosis induced by paclitaxel through an indirect mechanism
Lanni, Jennifer S., Lowe, Scott W., Licitra, Edward J., Liu, Jun O., Jacks, Tyler
The efficacy of chemotherapeutic agents may be determined by a number of different factors, including the genotype of the tumor cell. The p53 tumor suppressor gene frequently is mutated in human...
Griffith, Eric C., Su, Zhuang, Niwayama, Satomi, Ramsay, Cameron A., Chang, Yie-Hwa, Liu, Jun O.
Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer and other human diseases. Fumagillin and ovalicin compose a class of structurally related natural...
Kim, Min-Jung, Jo, Dong-Gyu, Hong, Gil-Sun, Kim, Byung Ju, Lai, Michael, Cho, Dong-Hyung, ...
Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during...
Huai, Qing, Kim, Hwa-Young, Liu, Yudong, Zhao, Yingdong, Mondragon, Angelo, Liu, Jun O., ...
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How...
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis
Youn, Hong-Duk, Chatila, Talal A., Liu, Jun O.
T-cell antigen receptor (TCR)-induced thymocyte apoptosis is mediated by calcium-dependent signal transduction pathways leading to the transcriptional activation of members of the Nur77 family. The...
Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation
Pan, Fan, Means, Anthony R, Liu, Jun O
Calcium signaling is critical for activation of T lymphocytes and has been proposed to be transduced through multiple calmodulin target proteins. Whereas the calcineurin–NFAT signaling module is...
Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
Zhang, Yi, Griffith, Eric C., Sage, Julien, Jacks, Tyler, Liu, Jun O.
Angiogenesis has been demonstrated to be essential for tumor growth and metastasis, and inhibition of angiogenesis is emerging as a promising strategy for treating cancer. Among the most potent...
p53-independent apoptosis induced by paclitaxel through an indirect mechanism
Lanni, Jennifer S., Lowe, Scott W., Licitra, Edward J., Liu, Jun O., Jacks, Tyler
The efficacy of chemotherapeutic agents may be determined by a number of different factors, including the genotype of the tumor cell. The p53 tumor suppressor gene frequently is mutated in human...
Griffith, Eric C., Su, Zhuang, Niwayama, Satomi, Ramsay, Cameron A., Chang, Yie-Hwa, Liu, Jun O.
Angiogenesis inhibitors are a novel class of promising therapeutic agents for treating cancer and other human diseases. Fumagillin and ovalicin compose a class of structurally related natural...
Kim, Min-Jung, Jo, Dong-Gyu, Hong, Gil-Sun, Kim, Byung Ju, Lai, Michael, Cho, Dong-Hyung, ...
Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during...
Huai, Qing, Kim, Hwa-Young, Liu, Yudong, Zhao, Yingdong, Mondragon, Angelo, Liu, Jun O., ...
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How...
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis
Youn, Hong-Duk, Chatila, Talal A., Liu, Jun O.
T-cell antigen receptor (TCR)-induced thymocyte apoptosis is mediated by calcium-dependent signal transduction pathways leading to the transcriptional activation of members of the Nur77 family. The...
Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation
Pan, Fan, Means, Anthony R, Liu, Jun O
Calcium signaling is critical for activation of T lymphocytes and has been proposed to be transduced through multiple calmodulin target proteins. Whereas the calcineurin–NFAT signaling module is...
Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity
Chen, Xiaochun, Chong, Curtis R., Shi, Lirong, Yoshimoto, Tadashi, Sullivan, David J., Liu, Jun O.
With >1 million deaths annually, mostly among children in sub-Saharan Africa, malaria poses one of the most critical challenges in medicine today. Although introduction of the artemisinin class of...
Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression
Hu, Xiaoyi, Addlagatta, Anthony, Lu, Jun, Matthews, Brian W., Liu, Jun O.
Processing of the N-terminal initiator methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The enzymes that remove N-terminal methionine are known as methionine...
Byrne, Sean T., Gu, Peihua, Zhou, Jiangbing, Denkin, Steven M., Chong, Curtis, Sullivan, David, ...
Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 μg/ml and 0.13 μg/ml, respectively. DETC and PDTC were active...
Esau, Christine, Boes, Marianne, Youn, Hong-Duk, Tatterson, Lisa, Liu, Jun O., Chen, Jianzhu
Cabin1 binds calcineurin and myocyte enhancer factor 2 (MEF2) through its COOH-terminal region. In cell lines, these interactions were shown to inhibit calcineurin activity after T cell receptor...
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α▿ †
Galbán, Stefanie, Kuwano, Yuki, Pullmann, Rudolf, Martindale, Jennifer L., Kim, Hyeon Ho, Lal, Ashish, ...
The levels of hypoxia-inducible factor 1α (HIF-1α) are tightly controlled. Here, we investigated the posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa cells...