Takaesu, Giichi, Ninomiya-Tsuji, Jun, Kishida, Satoshi, Li, Xiaoxia, Stark, George R., Matsumoto, Kunihiro
Interleukin-1 (IL-1) is a proinflammatory cytokine that recognizes a surface receptor complex and generates multiple cellular responses. IL-1 stimulation activates the mitogen-activated protein...
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK
Inoue, Hideki, Tateno, Minoru, Fujimura-Kamada, Konomi, Takaesu, Giichi, Adachi-Yamada, Takashi, Ninomiya-Tsuji, Jun, ...
In cultured mammalian cells, the p38 mitogen-activated protein kinase (MAPK) pathway is activated in response to a variety of environmental stresses. How ever, there is little evidence from in vivo...
Mizukami, Junko, Takaesu, Giichi, Akatsuka, Hiroyuki, Sakurai, Hiroaki, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro, ...
The receptor activator of NF-κB (RANK) and its ligand RANKL are key molecules for differentiation and activation of osteoclasts. RANKL stimulates transcription factors AP-1 through mitogen-activated...
Jiang, Zhengfan, Ninomiya-Tsuji, Jun, Qian, Youcun, Matsumoto, Kunihiro, Li, Xiaoxia
Interleukin-1 (IL-1) receptor-associated kinase (IRAK) plays an important role in the sequential formation and activation of IL-1-induced signaling complexes. Previous studies showed that IRAK is...
Ishitani, Tohru, Kishida, Satoshi, Hyodo-Miura, Junko, Ueno, Naoto, Yasuda, Jun, Waterman, Marian, ...
Wnt signaling controls a variety of developmental processes. The canonical Wnt/β-catenin pathway functions to stabilize β-catenin, and the noncanonical Wnt/Ca2+ pathway activates...
TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling
Sanjo, Hideki, Takeda, Kiyoshi, Tsujimura, Tohru, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro, Akira, Shizuo
The proinflammatory cytokine interleukin-1 (IL-1) transmits a signal via several critical cytoplasmic proteins such as MyD88, IRAKs and TRAF6. Recently, serine/threonine kinase TAK1 and TAK1 binding...
Ishitani, Tohru, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro
The Wnt/β-catenin signaling pathway regulates many developmental processes by modulating gene expression. Wnt signaling induces the stabilization of cytosolic β-catenin, which then associates with...
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
Ishitani, Tohru, Takaesu, Giichi, Ninomiya-Tsuji, Jun, Shibuya, Hiroshi, Gaynor, Richard B., Matsumoto, Kunihiro
The cytokines IL-1 and TNF induce expression of a series of genes that regulate inflammation through activation of NF-κB signal transduction pathways. TAK1, a MAPKKK, is critical for both IL-1- and...
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
Kanei-Ishii, Chie, Ninomiya-Tsuji, Jun, Tanikawa, Jun, Nomura, Teruaki, Ishitani, Tohru, Kishida, Satoshi, ...
The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of hematopoietic cells by inducing the transcription of a group of target genes. However, the biologically...
Tanaka-Hino, Miho, Sagasti, Alvaro, Hisamoto, Naoki, Kawasaki, Masato, Nakano, Shunji, Ninomiya-Tsuji, Jun, ...
The mitogen-activated protein kinase (MAPK) pathway is a highly conserved signaling cascade that converts extracellular signals into various outputs. In Caenorhabditis elegans, asymmetric expression...
Kishida, Satoshi, Sanjo, Hideki, Akira, Shizuo, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
TAK1 mitogen-activated protein kinase kinase kinase participates in the Interleukin-1 (IL-1) signaling pathway by mediating activation of JNK, p38, and NF-κB. TAK1-binding protein 2 (TAB2) was...
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation
Takeda, Kohsuke, Matsuzawa, Atsushi, Nishitoh, Hideki, Tobiume, Kei, Kishida, Satoshi, Ninomiya-Tsuji, Jun, ...
The mammalian mitogen-activated protein (MAP) kinase kinase kinase apoptosis signal-regulating kinase 1 (ASK1) is a pivotal component in cytokine- and stress-induced apoptosis. It also regulates cell...
Takaesu, Giichi, Ninomiya-Tsuji, Jun, Kishida, Satoshi, Li, Xiaoxia, Stark, George R., Matsumoto, Kunihiro
Interleukin-1 (IL-1) is a proinflammatory cytokine that recognizes a surface receptor complex and generates multiple cellular responses. IL-1 stimulation activates the mitogen-activated protein...
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK
Inoue, Hideki, Tateno, Minoru, Fujimura-Kamada, Konomi, Takaesu, Giichi, Adachi-Yamada, Takashi, Ninomiya-Tsuji, Jun, ...
In cultured mammalian cells, the p38 mitogen-activated protein kinase (MAPK) pathway is activated in response to a variety of environmental stresses. How ever, there is little evidence from in vivo...
Mizukami, Junko, Takaesu, Giichi, Akatsuka, Hiroyuki, Sakurai, Hiroaki, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro, ...
The receptor activator of NF-κB (RANK) and its ligand RANKL are key molecules for differentiation and activation of osteoclasts. RANKL stimulates transcription factors AP-1 through mitogen-activated...
Jiang, Zhengfan, Ninomiya-Tsuji, Jun, Qian, Youcun, Matsumoto, Kunihiro, Li, Xiaoxia
Interleukin-1 (IL-1) receptor-associated kinase (IRAK) plays an important role in the sequential formation and activation of IL-1-induced signaling complexes. Previous studies showed that IRAK is...
Ishitani, Tohru, Kishida, Satoshi, Hyodo-Miura, Junko, Ueno, Naoto, Yasuda, Jun, Waterman, Marian, ...
Wnt signaling controls a variety of developmental processes. The canonical Wnt/β-catenin pathway functions to stabilize β-catenin, and the noncanonical Wnt/Ca2+ pathway activates...
TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling
Sanjo, Hideki, Takeda, Kiyoshi, Tsujimura, Tohru, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro, Akira, Shizuo
The proinflammatory cytokine interleukin-1 (IL-1) transmits a signal via several critical cytoplasmic proteins such as MyD88, IRAKs and TRAF6. Recently, serine/threonine kinase TAK1 and TAK1 binding...
Ishitani, Tohru, Ninomiya-Tsuji, Jun, Matsumoto, Kunihiro
The Wnt/β-catenin signaling pathway regulates many developmental processes by modulating gene expression. Wnt signaling induces the stabilization of cytosolic β-catenin, which then associates with...
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
Ishitani, Tohru, Takaesu, Giichi, Ninomiya-Tsuji, Jun, Shibuya, Hiroshi, Gaynor, Richard B., Matsumoto, Kunihiro
The cytokines IL-1 and TNF induce expression of a series of genes that regulate inflammation through activation of NF-κB signal transduction pathways. TAK1, a MAPKKK, is critical for both IL-1- and...
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
Kanei-Ishii, Chie, Ninomiya-Tsuji, Jun, Tanikawa, Jun, Nomura, Teruaki, Ishitani, Tohru, Kishida, Satoshi, ...
The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of hematopoietic cells by inducing the transcription of a group of target genes. However, the biologically...
Tanaka-Hino, Miho, Sagasti, Alvaro, Hisamoto, Naoki, Kawasaki, Masato, Nakano, Shunji, Ninomiya-Tsuji, Jun, ...
The mitogen-activated protein kinase (MAPK) pathway is a highly conserved signaling cascade that converts extracellular signals into various outputs. In Caenorhabditis elegans, asymmetric expression...
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation
Takeda, Kohsuke, Matsuzawa, Atsushi, Nishitoh, Hideki, Tobiume, Kei, Kishida, Satoshi, Ninomiya-Tsuji, Jun, ...
The mammalian mitogen-activated protein (MAP) kinase kinase kinase apoptosis signal-regulating kinase 1 (ASK1) is a pivotal component in cytokine- and stress-induced apoptosis. It also regulates cell...