Julian C. Rutherford

A second iron-regulatory system in yeast independent of Aft1p

Rutherford, Julian C., Jaron, Shulamit, Ray, Esha, Brown, Patrick O., Winge, Dennis R.

Iron homeostasis in the yeast Saccharomyces cerevisiae is regulated at the transcriptional level by Aft1p, which activates the expression of its target genes in response to low-iron conditions. The...

Metal-Responsive Transcription Factors That Regulate Iron, Zinc, and Copper Homeostasis in Eukaryotic Cells

Rutherford, Julian C., Bird, Amanda J.

Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging

Koc, Ahmet, Gasch, Audrey P., Rutherford, Julian C., Kim, Hwa-Young, Gladyshev, Vadim N.

Aging is thought to be caused by the accumulation of damage, primarily from oxidative modifications of cellular components by reactive oxygen species (ROS). Here we used yeast methionine sulfoxide...

A second iron-regulatory system in yeast independent of Aft1p

Rutherford, Julian C., Jaron, Shulamit, Ray, Esha, Brown, Patrick O., Winge, Dennis R.

Iron homeostasis in the yeast Saccharomyces cerevisiae is regulated at the transcriptional level by Aft1p, which activates the expression of its target genes in response to low-iron conditions. The...

Metal-Responsive Transcription Factors That Regulate Iron, Zinc, and Copper Homeostasis in Eukaryotic Cells

Rutherford, Julian C., Bird, Amanda J.

Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging

Koc, Ahmet, Gasch, Audrey P., Rutherford, Julian C., Kim, Hwa-Young, Gladyshev, Vadim N.

Aging is thought to be caused by the accumulation of damage, primarily from oxidative modifications of cellular components by reactive oxygen species (ROS). Here we used yeast methionine sulfoxide...

Impact of Ammonium Permeases MepA, MepB, and MepC on Nitrogen-Regulated Secondary Metabolism in Fusarium fujikuroi▿

Teichert, Sabine, Rutherford, Julian C., Wottawa, Marieke, Heitman, Joseph, Tudzynski, Bettina

In Fusarium fujikuroi, the production of gibberellins and bikaverin is repressed by nitrogen sources such as glutamine or ammonium. Sensing and uptake of ammonium by specific permeases play key roles...

Amt2 Permease Is Required To Induce Ammonium-Responsive Invasive Growth and Mating in Cryptococcus neoformans▿

Rutherford, Julian C., Lin, Xiaorong, Nielsen, Kirsten, Heitman, Joseph

The conserved AmtB/Mep/Rh family of proteins mediate the transport of ammonium across cellular membranes in a wide range of organisms. Certain fungal members of this group are required to initiate...

A Mep2-dependent Transcriptional Profile Links Permease Function to Gene Expression during Pseudohyphal Growth in Saccharomyces cerevisiae

Rutherford, Julian C., Chua, Gordon, Hughes, Timothy, Cardenas, Maria E., Heitman, Joseph

The ammonium permease Mep2 is required for the induction of pseudohyphal growth, a process in Saccharomyces cerevisiae that occurs in response to nutrient limitation. Mep2 has both a transport and a...