Recognition of DNA by EcoRI Restriction Endonuclease and Methylase. (1998)
NMR Studies of Echinomycin-DNA Complexes include the interaction of echinomycin, a cyclic octadepsipeptide antibiotic, with DNA oligonucleotides. These complexes were studied by two-dimensional...
Koshlap, Karl M., Gillespie, Paul, Dervan, Peter B., Feigon, Juli
The synthetic deoxyribonucleoside 1-(2-deoxy-Beta-D-ribofuranosyl)-4-(3-benzamido)phenylimidazole (D3) has been shown to specifically recognize both T(dot)A and C(dot) G base pairs when incorporated...
Wu, Haihong, Yang, Pok K., Butcher, Samuel E., Kang, Sundeep, Chanfreau, Guillaume, Feigon, Juli
RNases III are a family of double-stranded RNA (dsRNA) endoribonucleases involved in the processing and decay of a large number of cellular RNAs as well as in RNA interference. The dsRNA substrates...
Theimer, Carla A., Finger, L. David, Trantirek, Lukas, Feigon, Juli
Autosomal dominant dyskeratosis congenita (DKC), as well as aplastic anemia, has been linked to mutations in the RNA component of telomerase, the ribonucleoprotein responsible for telomere...
Structural determinants for the binding of ubiquitin-like domains to the proteasome
Mueller, Thomas D., Feigon, Juli
HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting...
Finger, L. David, Trantirek, Lukas, Johansson, Carina, Feigon, Juli
Nucleolin, a multi-domain protein involved in ribosome biogenesis, has been shown to bind the consensus sequence (U/G)CCCG(A/G) in the context of a hairpin loop structure (nucleolin recognition...
Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin
Allain, Frédéric H.-T., Bouvet, Philippe, Dieckmann, Thorsten, Feigon, Juli
The structure of the 28 kDa complex of the first two RNA binding domains (RBDs) of nucleolin (RBD12) with an RNA stem–loop that includes the nucleolin recognition element UCCCGA in the loop was...
DNA A-tract bending in three dimensions: Solving the dA4T4 vs. dT4A4 conundrum
Stefl, Richard, Wu, Haihong, Ravindranathan, Sapna, Sklenář, Vladimír, Feigon, Juli
DNA A-tracts have been defined as four or more consecutive A·T base pairs without a TpA step. When inserted in phase with the DNA helical repeat, bending is manifested macroscopically as anomalous...
Wu, Haihong, Henras, Anthony, Chanfreau, Guillaume, Feigon, Juli
Specific recognition of double-stranded RNA (dsRNA) by dsRNA-binding domains (dsRBDs) is involved in a large number of biological and regulatory processes. Although structures of dsRBDs in complex...
Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element
Richards, Rebecca J., Theimer, Carla A., Finger, L. David, Feigon, Juli
Telomere addition by telomerase requires an internal templating sequence located in the RNA subunit of telomerase. The correct boundary definition of this template sequence is essential for the...
YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA
THEIMER, CARLA A., FINGER, L. DAVID, FEIGON, JULI
Autosomal dominant dyskeratosis congenita (DKC) has been linked to mutations in the RNA component of telomerase, the ribonucleoprotein responsible for telomere maintenance. Recent studies have...
HENRAS, ANTHONY K., SAM, MUI, HILEY, SHAWNA L., WU, HAIHONG, HUGHES, TIMOTHY R., FEIGON, JULI, ...
Members of the RNase III family of double-stranded RNA (dsRNA) endonucleases are important enzymes of RNA metabolism in eukaryotic cells. Rnt1p is the only known member of the RNase III family of...
Structural study of the H/ACA snoRNP components Nop10p and the 3′ hairpin of U65 snoRNA
KHANNA, MAY, WU, HAIHONG, JOHANSSON, CARINA, CAIZERGUES-FERRER, MICHÈLE, FEIGON, JULI
The H/ACA small nucleolar ribonucleoprotein (snoRNP) complexes guide the modification of uridine to pseudouridine at conserved sites in rRNA. The H/ACA snoRNPs each comprise a target-site-specific...
Wu, Haihong, Yang, Pok K., Butcher, Samuel E., Kang, Sundeep, Chanfreau, Guillaume, Feigon, Juli
RNases III are a family of double-stranded RNA (dsRNA) endoribonucleases involved in the processing and decay of a large number of cellular RNAs as well as in RNA interference. The dsRNA substrates...
Theimer, Carla A., Finger, L. David, Trantirek, Lukas, Feigon, Juli
Autosomal dominant dyskeratosis congenita (DKC), as well as aplastic anemia, has been linked to mutations in the RNA component of telomerase, the ribonucleoprotein responsible for telomere...
Structural determinants for the binding of ubiquitin-like domains to the proteasome
Mueller, Thomas D., Feigon, Juli
HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting...
Finger, L. David, Trantirek, Lukas, Johansson, Carina, Feigon, Juli
Nucleolin, a multi-domain protein involved in ribosome biogenesis, has been shown to bind the consensus sequence (U/G)CCCG(A/G) in the context of a hairpin loop structure (nucleolin recognition...
Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin
Allain, Frédéric H.-T., Bouvet, Philippe, Dieckmann, Thorsten, Feigon, Juli
The structure of the 28 kDa complex of the first two RNA binding domains (RBDs) of nucleolin (RBD12) with an RNA stem–loop that includes the nucleolin recognition element UCCCGA in the loop was...
DNA A-tract bending in three dimensions: Solving the dA4T4 vs. dT4A4 conundrum
Stefl, Richard, Wu, Haihong, Ravindranathan, Sapna, Sklenář, Vladimír, Feigon, Juli
DNA A-tracts have been defined as four or more consecutive A·T base pairs without a TpA step. When inserted in phase with the DNA helical repeat, bending is manifested macroscopically as anomalous...
Wu, Haihong, Henras, Anthony, Chanfreau, Guillaume, Feigon, Juli
Specific recognition of double-stranded RNA (dsRNA) by dsRNA-binding domains (dsRBDs) is involved in a large number of biological and regulatory processes. Although structures of dsRBDs in complex...
Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element
Richards, Rebecca J., Theimer, Carla A., Finger, L. David, Feigon, Juli
Telomere addition by telomerase requires an internal templating sequence located in the RNA subunit of telomerase. The correct boundary definition of this template sequence is essential for the...
YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA
THEIMER, CARLA A., FINGER, L. DAVID, FEIGON, JULI
Autosomal dominant dyskeratosis congenita (DKC) has been linked to mutations in the RNA component of telomerase, the ribonucleoprotein responsible for telomere maintenance. Recent studies have...
HENRAS, ANTHONY K., SAM, MUI, HILEY, SHAWNA L., WU, HAIHONG, HUGHES, TIMOTHY R., FEIGON, JULI, ...
Members of the RNase III family of double-stranded RNA (dsRNA) endonucleases are important enzymes of RNA metabolism in eukaryotic cells. Rnt1p is the only known member of the RNase III family of...
Structural study of the H/ACA snoRNP components Nop10p and the 3′ hairpin of U65 snoRNA
KHANNA, MAY, WU, HAIHONG, JOHANSSON, CARINA, CAIZERGUES-FERRER, MICHÈLE, FEIGON, JULI
The H/ACA small nucleolar ribonucleoprotein (snoRNP) complexes guide the modification of uridine to pseudouridine at conserved sites in rRNA. The H/ACA snoRNPs each comprise a target-site-specific...
Richards, Rebecca J., Wu, Haihong, Trantirek, Lukas, O'Connor, Catherine M., Collins, Kathleen, Feigon, Juli
Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem–loop IV domain, which is involved in both...
During the biogenesis of eukaryotic ribosomal RNA (rRNA) and spliceosomal small nuclear RNA (snRNA), uridines at specific sites are converted to pseudouridines by H/ACA ribonucleoprotein particles...
Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction
Kamionka, Mariusz, Feigon, Juli
Rad23 proteins are involved both in the ubiquitin-proteasome pathway and in nucleotide excision repair (NER), but the relationship between these two pathways is not yet understood. The two human...